Practical Considerations of PRN Medicines Management: An Integrative Systematic Review

Mardani, Abbas; Paal, Piret; Weck, Christiane; Jamshed, Shazia; Vaismoradi, Mojtaba

doi:10.3389/fphar.2022.759998

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Practical Considerations of PRN Medicines Management: An Integrative Systematic Review

Abbas Mardani, Piret Paal, Christiane Weck, Shazia Jamshed, Mojtaba Vaismoradi

Frontiers in Pharmacology, Volume: 13

Swansea University Author: Mojtaba Vaismoradi

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DOI (Published version): 10.3389/fphar.2022.759998

Abstract

Background and objectives: Highly widespread use of pro re nata (PRN) medicines in various healthcare settings is a potential area for improper medication prescription and administration leading to patient harm. This study aimed to summarize and integrate the findings of all relevant individual stud...

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Published in:	Frontiers in Pharmacology
ISSN:	1663-9812
Published:	Frontiers Media SA 2022
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URI:	https://cronfa.swan.ac.uk/Record/cronfa59797
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first_indexed	2022-04-12T06:33:11Z
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This study aimed to summarize and integrate the findings of all relevant individual studies regarding the practical considerations of PRN medicines management including strategies and interventions by healthcare professionals for safe prescription, dispensing, administration, monitoring, and deprescription of PRN medicines in healthcare settings.Methods: An integrative systematic review on international databases were performed. Electronic databases including Web of Knowledge, Scopus, PubMed (including MEDLINE), and Cinahl were searched to retrieve articles published until end of May 2021. Original qualitative, quantitative, and mixed methods studies written in English were included with a focus on PRN medicines management in healthcare settings. Research synthesis using the narrative method was performed to summarise the results of included studies.Results: Thirty-one studies on PRN medicines in healthcare settings by different healthcare providers were included after the screening of the databases based on eligibility criteria. They were published from 1987 to 2021. The majority of studies were from Australia, the United States, Canada, and the United Kingdom and were conducted in psychiatric settings. Given variations in their purposes, methods, and outcomes, the research synthesis was conducted narratively based on diversities and similarities in findings. Eight categories were developed by the authors as follows: “PRN indications and precautionary measures,” “requirements of PRN prescription,” “interventions for PRN administration,” “monitoring and follow up interventions,” “deprescription strategies,” “healthcare professionals’ role,” “participation of patients and families,” and “multidisciplinary collaboration.” Each category consists of several items and describes what factors should be considered by healthcare professionals for PRN medicines management.Conclusion: The review findings provide insights on the practical considerations of PRN medicines management in clinical practice. The suggested list of considerations in our review can be used by healthcare professionals for optimal PRN medicines management and safeguarding patient care.</abstract><type>Journal Article</type><journal>Frontiers in Pharmacology</journal><volume>13</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Frontiers Media SA</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>1663-9812</issnElectronic><keywords>clinical practice, medication, medicines management, patient safety, pro re nata</keywords><publishedDay>12</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2022</publishedYear><publishedDate>2022-04-12</publishedDate><doi>10.3389/fphar.2022.759998</doi><url/><notes/><college>COLLEGE NANME</college><department>Medicine, Health and Life Science - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGMHL</DepartmentCode><institution>Swansea University</institution><apcterm>Another institution paid the OA fee</apcterm><funders>Nord University</funders><lastEdited>2022-05-09T14:29:44.3270316</lastEdited><Created>2022-04-12T07:28:27.7252365</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">School of Health and Social Care - Nursing</level></path><authors><author><firstname>Abbas</firstname><surname>Mardani</surname><order>1</order></author><author><firstname>Piret</firstname><surname>Paal</surname><order>2</order></author><author><firstname>Christiane</firstname><surname>Weck</surname><order>3</order></author><author><firstname>Shazia</firstname><surname>Jamshed</surname><order>4</order></author><author><firstname>Mojtaba</firstname><surname>Vaismoradi</surname><order>5</order></author></authors><documents><document><filename>59797__23808__b5eb57700f0a4985880df5db4cb17f8e.pdf</filename><originalFilename>PRN 2022 Frontiers in Pharmacology.pdf</originalFilename><uploaded>2022-04-12T07:31:47.2665054</uploaded><type>Output</type><contentLength>1186795</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>Copyright © 2022 Mardani, Paal, Weck, Jamshed and Vaismoradi. 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spelling	2022-05-09T14:29:44.3270316 v2 59797 2022-04-12 Practical Considerations of PRN Medicines Management: An Integrative Systematic Review b865b33654e99f5cbccdb11350f7b069 Mojtaba Vaismoradi Mojtaba Vaismoradi true false 2022-04-12 FGMHL Background and objectives: Highly widespread use of pro re nata (PRN) medicines in various healthcare settings is a potential area for improper medication prescription and administration leading to patient harm. This study aimed to summarize and integrate the findings of all relevant individual studies regarding the practical considerations of PRN medicines management including strategies and interventions by healthcare professionals for safe prescription, dispensing, administration, monitoring, and deprescription of PRN medicines in healthcare settings.Methods: An integrative systematic review on international databases were performed. Electronic databases including Web of Knowledge, Scopus, PubMed (including MEDLINE), and Cinahl were searched to retrieve articles published until end of May 2021. Original qualitative, quantitative, and mixed methods studies written in English were included with a focus on PRN medicines management in healthcare settings. Research synthesis using the narrative method was performed to summarise the results of included studies.Results: Thirty-one studies on PRN medicines in healthcare settings by different healthcare providers were included after the screening of the databases based on eligibility criteria. They were published from 1987 to 2021. The majority of studies were from Australia, the United States, Canada, and the United Kingdom and were conducted in psychiatric settings. Given variations in their purposes, methods, and outcomes, the research synthesis was conducted narratively based on diversities and similarities in findings. Eight categories were developed by the authors as follows: “PRN indications and precautionary measures,” “requirements of PRN prescription,” “interventions for PRN administration,” “monitoring and follow up interventions,” “deprescription strategies,” “healthcare professionals’ role,” “participation of patients and families,” and “multidisciplinary collaboration.” Each category consists of several items and describes what factors should be considered by healthcare professionals for PRN medicines management.Conclusion: The review findings provide insights on the practical considerations of PRN medicines management in clinical practice. The suggested list of considerations in our review can be used by healthcare professionals for optimal PRN medicines management and safeguarding patient care. Journal Article Frontiers in Pharmacology 13 Frontiers Media SA 1663-9812 clinical practice, medication, medicines management, patient safety, pro re nata 12 4 2022 2022-04-12 10.3389/fphar.2022.759998 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University Another institution paid the OA fee Nord University 2022-05-09T14:29:44.3270316 2022-04-12T07:28:27.7252365 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing Abbas Mardani 1 Piret Paal 2 Christiane Weck 3 Shazia Jamshed 4 Mojtaba Vaismoradi 5 59797__23808__b5eb57700f0a4985880df5db4cb17f8e.pdf PRN 2022 Frontiers in Pharmacology.pdf 2022-04-12T07:31:47.2665054 Output 1186795 application/pdf Version of Record true Copyright © 2022 Mardani, Paal, Weck, Jamshed and Vaismoradi. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) true eng https://creativecommons.org/licenses/by/4.0/
title	Practical Considerations of PRN Medicines Management: An Integrative Systematic Review
spellingShingle	Practical Considerations of PRN Medicines Management: An Integrative Systematic Review Mojtaba Vaismoradi
title_short	Practical Considerations of PRN Medicines Management: An Integrative Systematic Review
title_full	Practical Considerations of PRN Medicines Management: An Integrative Systematic Review
title_fullStr	Practical Considerations of PRN Medicines Management: An Integrative Systematic Review
title_full_unstemmed	Practical Considerations of PRN Medicines Management: An Integrative Systematic Review
title_sort	Practical Considerations of PRN Medicines Management: An Integrative Systematic Review
author_id_str_mv	b865b33654e99f5cbccdb11350f7b069
author_id_fullname_str_mv	b865b33654e99f5cbccdb11350f7b069_***_Mojtaba Vaismoradi
author	Mojtaba Vaismoradi
author2	Abbas Mardani Piret Paal Christiane Weck Shazia Jamshed Mojtaba Vaismoradi
format	Journal article
container_title	Frontiers in Pharmacology
container_volume	13
publishDate	2022
institution	Swansea University
issn	1663-9812
doi_str_mv	10.3389/fphar.2022.759998
publisher	Frontiers Media SA
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
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hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
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description	Background and objectives: Highly widespread use of pro re nata (PRN) medicines in various healthcare settings is a potential area for improper medication prescription and administration leading to patient harm. This study aimed to summarize and integrate the findings of all relevant individual studies regarding the practical considerations of PRN medicines management including strategies and interventions by healthcare professionals for safe prescription, dispensing, administration, monitoring, and deprescription of PRN medicines in healthcare settings.Methods: An integrative systematic review on international databases were performed. Electronic databases including Web of Knowledge, Scopus, PubMed (including MEDLINE), and Cinahl were searched to retrieve articles published until end of May 2021. Original qualitative, quantitative, and mixed methods studies written in English were included with a focus on PRN medicines management in healthcare settings. Research synthesis using the narrative method was performed to summarise the results of included studies.Results: Thirty-one studies on PRN medicines in healthcare settings by different healthcare providers were included after the screening of the databases based on eligibility criteria. They were published from 1987 to 2021. The majority of studies were from Australia, the United States, Canada, and the United Kingdom and were conducted in psychiatric settings. Given variations in their purposes, methods, and outcomes, the research synthesis was conducted narratively based on diversities and similarities in findings. Eight categories were developed by the authors as follows: “PRN indications and precautionary measures,” “requirements of PRN prescription,” “interventions for PRN administration,” “monitoring and follow up interventions,” “deprescription strategies,” “healthcare professionals’ role,” “participation of patients and families,” and “multidisciplinary collaboration.” Each category consists of several items and describes what factors should be considered by healthcare professionals for PRN medicines management.Conclusion: The review findings provide insights on the practical considerations of PRN medicines management in clinical practice. The suggested list of considerations in our review can be used by healthcare professionals for optimal PRN medicines management and safeguarding patient care.
published_date	2022-04-12T04:17:22Z
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Practical Considerations of PRN Medicines Management: An Integrative Systematic Review

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