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Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments

Anoshanth Jeyasountharan Orcid Logo, Gaetano D'Avino Orcid Logo, Francesco Del Giudice Orcid Logo

Physics of Fluids, Volume: 34, Issue: 4, Start page: 042015

Swansea University Author: Francesco Del Giudice Orcid Logo

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DOI (Published version): 10.1063/5.0090997

Abstract

Strings of equally spaced particles, also called particle trains, have been employed in several applications, including flow cytometry and particle or cell encapsulation. Recently, the formation of particle trains in viscoelastic liquids has been demonstrated. However, only a few studies have focuse...

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Published in: Physics of Fluids
ISSN: 1070-6631 1089-7666
Published: AIP Publishing 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa59794
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spelling 2022-10-31T17:51:28.8615050 v2 59794 2022-04-11 Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2022-04-11 EAAS Strings of equally spaced particles, also called particle trains, have been employed in several applications, including flow cytometry and particle or cell encapsulation. Recently, the formation of particle trains in viscoelastic liquids has been demonstrated. However, only a few studies have focused on the topic, with several questions remaining unanswered. We here perform numerical simulations and experiments to elucidate the effect of the confinement ratio on the self-ordering dynamics of particles suspended in a viscoelastic liquid and flowing on the centerline of a microfluidic channel. For a fixed channel size, the particles self-order on shorter distances as the particle size increases due to the enhanced hydrodynamic interactions. At relatively low linear concentrations, the relative particle velocities scale with the fourth power of the confinement ratio when plotted as a function of the distance between the particle surfaces normalized by the channel diameter. As the linear concentration increases, the average interparticle spacing reduces and the scaling is lost, with an increasing probability to form strings of particles in contact. To reduce the number of aggregates, a microfluidic device made of an array of trapezoidal elements is fabricated and tested. The particle aggregates reduce down to 5% of the overall particle number, significantly enhancing the ordering efficiency. A good agreement between numerical simulations and experiments is found. Journal Article Physics of Fluids 34 4 042015 AIP Publishing 1070-6631 1089-7666 21 4 2022 2022-04-21 10.1063/5.0090997 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University External research funder(s) paid the OA fee (includes OA grants disbursed by the Library) UKRI, EPSRC EP/S036490/1 2022-10-31T17:51:28.8615050 2022-04-11T13:03:05.9134431 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Anoshanth Jeyasountharan 0000-0002-7229-0532 1 Gaetano D'Avino 0000-0002-0333-6330 2 Francesco Del Giudice 0000-0002-9414-6937 3 59794__24037__bdc3ca9fd1a341c39ddc05aeaccc1622.pdf 59794.pdf 2022-05-09T14:42:57.1057267 Output 4262772 application/pdf Version of Record true Copyright: 2022 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license true eng http://creativecommons.org/licenses/by/4.0/
title Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments
spellingShingle Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments
Francesco Del Giudice
title_short Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments
title_full Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments
title_fullStr Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments
title_full_unstemmed Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments
title_sort Confinement effect on the viscoelastic particle ordering in microfluidic flows: Numerical simulations and experiments
author_id_str_mv 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv 742d483071479b44d7888e16166b1309_***_Francesco Del Giudice
author Francesco Del Giudice
author2 Anoshanth Jeyasountharan
Gaetano D'Avino
Francesco Del Giudice
format Journal article
container_title Physics of Fluids
container_volume 34
container_issue 4
container_start_page 042015
publishDate 2022
institution Swansea University
issn 1070-6631
1089-7666
doi_str_mv 10.1063/5.0090997
publisher AIP Publishing
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description Strings of equally spaced particles, also called particle trains, have been employed in several applications, including flow cytometry and particle or cell encapsulation. Recently, the formation of particle trains in viscoelastic liquids has been demonstrated. However, only a few studies have focused on the topic, with several questions remaining unanswered. We here perform numerical simulations and experiments to elucidate the effect of the confinement ratio on the self-ordering dynamics of particles suspended in a viscoelastic liquid and flowing on the centerline of a microfluidic channel. For a fixed channel size, the particles self-order on shorter distances as the particle size increases due to the enhanced hydrodynamic interactions. At relatively low linear concentrations, the relative particle velocities scale with the fourth power of the confinement ratio when plotted as a function of the distance between the particle surfaces normalized by the channel diameter. As the linear concentration increases, the average interparticle spacing reduces and the scaling is lost, with an increasing probability to form strings of particles in contact. To reduce the number of aggregates, a microfluidic device made of an array of trapezoidal elements is fabricated and tested. The particle aggregates reduce down to 5% of the overall particle number, significantly enhancing the ordering efficiency. A good agreement between numerical simulations and experiments is found.
published_date 2022-04-21T16:52:08Z
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