Journal article 785 views 61 downloads
Host ecology regulates interspecies recombination in bacteria of the genus Campylobacter
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Koji Yahara ,
Sion C Bayliss ,
Jessica K Calland,
Håkan Johansson,
Leonardos Mageiros ,
Zilia Y Muñoz-Ramirez ,
Grant Futcher,
Guillaume Méric ,
Matthew Hitchings ,
Santiago Sandoval-Motta,
Javier Torres ,
Keith A Jolley ,
Martin CJ Maiden ,
Patrik Ellström,
Jonas Waldenström ,
Ben Pascoe ,
Samuel K Sheppard
eLife, Volume: 11
Swansea University Authors:
Matthew Hitchings , Ben Pascoe
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Copyright Mourkas et al. This article is distributed under the terms of the Creative Commons Attribution License
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DOI (Published version): 10.7554/elife.73552
Abstract
Horizontal gene transfer (HGT) can allow traits that have evolved in one bacterial species to transfer to another. This has potential to rapidly promote new adaptive trajectories such as zoonotic transfer or antimicrobial resistance. However, for this to occur requires gaps to align in barriers to r...
| Published in: | eLife |
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| ISSN: | 2050-084X |
| Published: |
eLife Sciences Publications, Ltd
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa59565 |
| Abstract: |
Horizontal gene transfer (HGT) can allow traits that have evolved in one bacterial species to transfer to another. This has potential to rapidly promote new adaptive trajectories such as zoonotic transfer or antimicrobial resistance. However, for this to occur requires gaps to align in barriers to recombination within a given time frame. Chief among these barriers is the physical separation of species with distinct ecologies in separate niches. Within the genus there are species with divergent ecologies, from rarely isolated single host specialists to multi-host generalist species that are among the most common global causes of human bacterial gastroenteritis. Here, by characterising these contrasting ecologies, we can quantify HGT among sympatric and allopatric species in natural populations. Analysing recipient and donor population ancestry among genomes from 30 species we show that cohabitation in the same host can lead to a 6-fold increase in HGT between species. This accounts for up to 30% of all SNPs within a given species and identifies highly recombinogenic genes with functions including host adaptation and antimicrobial resistance. As described in some animal and plant species, ecological factors are a major evolutionary force for speciation in bacteria and changes to the host landscape can promote partial convergence of distinct species through HGT. [Abstract copyright: © 2022, Mourkas et al.] |
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| Keywords: |
Campylobacter, genus, species, niche, adaptation, host, evolution |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This work was supported by Wellcome Trust grants 088786/C/09/Z and Medical Research Council
(MRC) grants MR/M501608/1 and MR/L015080/1 awarded to SKS |