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Destruction of Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure

GABRIELA FRIANI Orcid Logo, VALDIR A. COSTA Orcid Logo, ESTER MOTA Orcid Logo, MARTA JÚLIA FARO Orcid Logo, SAMALY SOUZA Orcid Logo, Marcela Barbosa Figueiredo Santangelo, PATRÍCIA S. GÔLO Orcid Logo, CLÉLIA CHRISTINA MELLO-SILVA Orcid Logo

Anais da Academia Brasileira de Ciências, Volume: 94, Issue: 2, Start page: e20190676

Swansea University Author: Marcela Barbosa Figueiredo Santangelo

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DOI (Published version): 10.1590/0001-3765202220200620

Abstract

Schistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni. The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathol...

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Published in: Anais da Academia Brasileira de Ciências
ISSN: 0001-3765 1678-2690
Published: FapUNIFESP (SciELO) 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa59555
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Abstract: Schistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni. The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathology of B. glabrata infected by S. mansoni. Uninfected and infected snails were exposed to sublethal concentration of E. milii latex for 24 hours (1.0 mg/L). The survival rate was 88.5% for the uninfected snails and 66.6% for the infected and exposed snails. In the snails infected by S. mansoni, the exposure to E. milii latex promoted proliferation of hemocytes in the tentacles, mantle, digestive gland and kidney. In the digestive gland and the kidney, granulomatous reactions occurred around the sporocysts and caused their destruction. The number of circulating hemocytes from the group infected and exposed to E. milii latex was significantly higher than in the other groups. Three types of hemocytes were found: hyalinocytes, granulocytes and blast-like cells. We conclude that the E. milii latex influenced the cellular immune response of the susceptible B. glabrata strain to infection by S. mansoni, promoting the destruction of parasites.
Keywords: Biomphalaria glabrata; Euphorbia milii; hemocytes; phytochemical; susceptibility
College: Faculty of Medicine, Health and Life Sciences
Funders: Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior – Brasil (CAPES) - Finance code 001; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ- Bolsista nota 10 program) and Fundação Oswaldo Cruz (PAEF IOC-008 FIO-04).
Issue: 2
Start Page: e20190676

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