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Receptor-ligand diffusion-limited reaction rates on curved membranes

Rob Daniels Orcid Logo

Chemical Physics Letters, Volume: 795, Start page: 139516

Swansea University Author: Rob Daniels Orcid Logo

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DOI (Published version): 10.1016/j.cplett.2022.139516

Abstract

We provide an expression for the diffusion-limited reaction rate on a curved surface, or membrane, in the perturbative deformation regime. This result is applied to the specific case of calculating the receptor-ligand association rate at membrane deforming, transmembrane receptor proteins, or inclus...

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Published in: Chemical Physics Letters
ISSN: 0009-2614
Published: Elsevier BV 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa59480
first_indexed 2022-03-02T08:40:20Z
last_indexed 2023-01-11T14:40:47Z
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spelling 2022-10-31T17:48:52.5744949 v2 59480 2022-03-02 Receptor-ligand diffusion-limited reaction rates on curved membranes 23f38c3bb732d4378986bdfaf7b6ee51 0000-0002-6933-8144 Rob Daniels Rob Daniels true false 2022-03-02 EAAS We provide an expression for the diffusion-limited reaction rate on a curved surface, or membrane, in the perturbative deformation regime. This result is applied to the specific case of calculating the receptor-ligand association rate at membrane deforming, transmembrane receptor proteins, or inclusions. The dynamics of mechanochemical coupling between chemical activity and local membrane curvature is further investigated, and the effect of thermal membrane fluctuations is also discussed. It is found for transmembrane proteins, or inclusions, that their concomitant receptor-ligand reaction rates can be typically reduced by as much as 20% due to the effect of locally induced membrane curvature or geometry. Journal Article Chemical Physics Letters 795 139516 Elsevier BV 0009-2614 Receptor, ligand, reaction rate, membrane, diffusion, curvature. 16 5 2022 2022-05-16 10.1016/j.cplett.2022.139516 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University SU Library paid the OA fee (TA Institutional Deal) 2022-10-31T17:48:52.5744949 2022-03-02T08:37:54.8685613 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Rob Daniels 0000-0002-6933-8144 1 59480__24045__da2854ddbdab4b41a4cb6cf50fef8c36.pdf 59480.VOR.pdf 2022-05-09T17:18:04.0733427 Output 588916 application/pdf Version of Record true Distributed under the terms of a Creative Commons Attribution 4.0 (CC-BY) Licence. true eng https://creativecommons.org/licenses/by/4.0/
title Receptor-ligand diffusion-limited reaction rates on curved membranes
spellingShingle Receptor-ligand diffusion-limited reaction rates on curved membranes
Rob Daniels
title_short Receptor-ligand diffusion-limited reaction rates on curved membranes
title_full Receptor-ligand diffusion-limited reaction rates on curved membranes
title_fullStr Receptor-ligand diffusion-limited reaction rates on curved membranes
title_full_unstemmed Receptor-ligand diffusion-limited reaction rates on curved membranes
title_sort Receptor-ligand diffusion-limited reaction rates on curved membranes
author_id_str_mv 23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 23f38c3bb732d4378986bdfaf7b6ee51_***_Rob Daniels
author Rob Daniels
author2 Rob Daniels
format Journal article
container_title Chemical Physics Letters
container_volume 795
container_start_page 139516
publishDate 2022
institution Swansea University
issn 0009-2614
doi_str_mv 10.1016/j.cplett.2022.139516
publisher Elsevier BV
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
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description We provide an expression for the diffusion-limited reaction rate on a curved surface, or membrane, in the perturbative deformation regime. This result is applied to the specific case of calculating the receptor-ligand association rate at membrane deforming, transmembrane receptor proteins, or inclusions. The dynamics of mechanochemical coupling between chemical activity and local membrane curvature is further investigated, and the effect of thermal membrane fluctuations is also discussed. It is found for transmembrane proteins, or inclusions, that their concomitant receptor-ligand reaction rates can be typically reduced by as much as 20% due to the effect of locally induced membrane curvature or geometry.
published_date 2022-05-16T09:15:52Z
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