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Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization

Julian Konzok, Gina-Isabelle Henze, Ludwig Kreuzpointner, Hannah L. Peter, Marina Giglberger, Christoph Bärtl, Claudia Massau, Christian Kärgel, Kathrin Weidacker Orcid Logo, Boris Schiffer, Hedwig Eisenbarth, Stefan Wüst, Brigitte M. Kudielka

Cognitive, Affective, and Behavioral Neuroscience, Volume: 22, Issue: 5, Pages: 1130 - 1144

Swansea University Author: Kathrin Weidacker Orcid Logo

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DOI (Published version): 10.3758/s13415-021-00981-y

Abstract

The externalizing spectrum describes a range of heterogeneous personality traits and behavioral patterns, primarily characterized by antisocial behavior, disinhibition, and substance (mis)use. In psychopathology, abnormalities in neural threat, reward responses and the impulse-control system may be...

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Published in: Cognitive, Affective, and Behavioral Neuroscience
ISSN: 1530-7026 1531-135X
Published: Springer Science and Business Media LLC 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa59287
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Within the non-clinical range, mechanisms remain still unclear. In this fMRI-study, 61 healthy participants (31 men) from the higher versus lower range of the non-clinical variation in externalization (31 participants with high externalization) as assessed by the subscales disinhibition and meanness of the Triarchic-Psychopathy-Measure (TriPM) performed a monetary modified Taylor-Aggression-Paradigm (mTAP). This paradigm consisted of a mock competitive-reaction-time-task played against a fictional opponent with preprogrammed win- and lose-trials. In lose-trials, participants were provoked by subtraction of an amount of money between 0 and 90 cents. As a manipulation check, provocation induced a significant rise in behavioral aggression levels linked with an increased activation in the anterior cingulate cortex (ACC). High externalization predicted reduced ACC responses to provocation. However, high externalizing participants did not behave more aggressively than the low externalization group. Additionally, the high externalizing group showed a significantly lower positive affect while no group differences emerged for negative affect. In conclusion, high externalization in the non-clinical range was related to neural alterations in regions involved in affective decision-making as well as to changes in affect but did not lead to higher behavioral aggression levels in response to the mTAP. 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spelling 2022-10-18T16:05:21.4999965 v2 59287 2022-02-01 Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization 4fed7fdf5381ec1a577001d6bd3d74d8 0000-0002-5742-6016 Kathrin Weidacker Kathrin Weidacker true false 2022-02-01 HPS The externalizing spectrum describes a range of heterogeneous personality traits and behavioral patterns, primarily characterized by antisocial behavior, disinhibition, and substance (mis)use. In psychopathology, abnormalities in neural threat, reward responses and the impulse-control system may be responsible for these externalizing symptoms. Within the non-clinical range, mechanisms remain still unclear. In this fMRI-study, 61 healthy participants (31 men) from the higher versus lower range of the non-clinical variation in externalization (31 participants with high externalization) as assessed by the subscales disinhibition and meanness of the Triarchic-Psychopathy-Measure (TriPM) performed a monetary modified Taylor-Aggression-Paradigm (mTAP). This paradigm consisted of a mock competitive-reaction-time-task played against a fictional opponent with preprogrammed win- and lose-trials. In lose-trials, participants were provoked by subtraction of an amount of money between 0 and 90 cents. As a manipulation check, provocation induced a significant rise in behavioral aggression levels linked with an increased activation in the anterior cingulate cortex (ACC). High externalization predicted reduced ACC responses to provocation. However, high externalizing participants did not behave more aggressively than the low externalization group. Additionally, the high externalizing group showed a significantly lower positive affect while no group differences emerged for negative affect. In conclusion, high externalization in the non-clinical range was related to neural alterations in regions involved in affective decision-making as well as to changes in affect but did not lead to higher behavioral aggression levels in response to the mTAP. This is in line with previous findings suggesting that aberrations at multiple levels are essential for developing externalizing disorders. Journal Article Cognitive, Affective, and Behavioral Neuroscience 22 5 1130 1144 Springer Science and Business Media LLC 1530-7026 1531-135X Taylor Aggression Paradigm; Externalizing spectrum; fMRI; Anterior cingulate cortex 1 10 2022 2022-10-01 10.3758/s13415-021-00981-y COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University This work was supported by grant number KU 1401/6-1 assigned to Brigitte M. 591 Kudielka, Stefan Wüst, Hedwig Eisenbarth and Boris Schiffer funded by the German Research 592 Foundation (DFG). Gina-Isabelle Henze acknowledges support by the Hanns Seidel 593 Foundation. Open Access funding enabled and organized by Projekt DEAL. 2022-10-18T16:05:21.4999965 2022-02-01T11:39:56.7603824 Faculty of Medicine, Health and Life Sciences School of Psychology Julian Konzok 1 Gina-Isabelle Henze 2 Ludwig Kreuzpointner 3 Hannah L. Peter 4 Marina Giglberger 5 Christoph Bärtl 6 Claudia Massau 7 Christian Kärgel 8 Kathrin Weidacker 0000-0002-5742-6016 9 Boris Schiffer 10 Hedwig Eisenbarth 11 Stefan Wüst 12 Brigitte M. Kudielka 13 59287__22293__513d026ee3d44a3d9fe534700bf258f7.pdf 59287.pdf 2022-02-02T16:01:24.0207076 Output 1177791 application/pdf Version of Record true © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization
spellingShingle Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization
Kathrin Weidacker
title_short Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization
title_full Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization
title_fullStr Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization
title_full_unstemmed Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization
title_sort Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization
author_id_str_mv 4fed7fdf5381ec1a577001d6bd3d74d8
author_id_fullname_str_mv 4fed7fdf5381ec1a577001d6bd3d74d8_***_Kathrin Weidacker
author Kathrin Weidacker
author2 Julian Konzok
Gina-Isabelle Henze
Ludwig Kreuzpointner
Hannah L. Peter
Marina Giglberger
Christoph Bärtl
Claudia Massau
Christian Kärgel
Kathrin Weidacker
Boris Schiffer
Hedwig Eisenbarth
Stefan Wüst
Brigitte M. Kudielka
format Journal article
container_title Cognitive, Affective, and Behavioral Neuroscience
container_volume 22
container_issue 5
container_start_page 1130
publishDate 2022
institution Swansea University
issn 1530-7026
1531-135X
doi_str_mv 10.3758/s13415-021-00981-y
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
active_str 0
description The externalizing spectrum describes a range of heterogeneous personality traits and behavioral patterns, primarily characterized by antisocial behavior, disinhibition, and substance (mis)use. In psychopathology, abnormalities in neural threat, reward responses and the impulse-control system may be responsible for these externalizing symptoms. Within the non-clinical range, mechanisms remain still unclear. In this fMRI-study, 61 healthy participants (31 men) from the higher versus lower range of the non-clinical variation in externalization (31 participants with high externalization) as assessed by the subscales disinhibition and meanness of the Triarchic-Psychopathy-Measure (TriPM) performed a monetary modified Taylor-Aggression-Paradigm (mTAP). This paradigm consisted of a mock competitive-reaction-time-task played against a fictional opponent with preprogrammed win- and lose-trials. In lose-trials, participants were provoked by subtraction of an amount of money between 0 and 90 cents. As a manipulation check, provocation induced a significant rise in behavioral aggression levels linked with an increased activation in the anterior cingulate cortex (ACC). High externalization predicted reduced ACC responses to provocation. However, high externalizing participants did not behave more aggressively than the low externalization group. Additionally, the high externalizing group showed a significantly lower positive affect while no group differences emerged for negative affect. In conclusion, high externalization in the non-clinical range was related to neural alterations in regions involved in affective decision-making as well as to changes in affect but did not lead to higher behavioral aggression levels in response to the mTAP. This is in line with previous findings suggesting that aberrations at multiple levels are essential for developing externalizing disorders.
published_date 2022-10-01T04:16:28Z
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