Journal article 522 views 94 downloads
Misuse of Anticholinergic Medications: A Systematic Review
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Alessio Mosca ,
Andrea Miuli ,
Francesco Maria Semeraro,
Gianluca Mancusi,
Maria Chiara Santovito,
Francesco Di Carlo ,
Mauro Pettorruso ,
Amira Guirguis ,
John Martin Corkery ,
Giovanni Martinotti ,
Fabrizio Schifano,
Massimo Di Giannantonio
Biomedicines, Volume: 10, Issue: 2, Start page: 355
Swansea University Author:
Amira Guirguis
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DOI (Published version): 10.3390/biomedicines10020355
Abstract
(1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the r...
| Published in: | Biomedicines |
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| ISSN: | 2227-9059 |
| Published: |
UK
MDPI AG
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa59266 |
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| Abstract: |
(1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the relevant published data, focusing on the following molecules: benztropine, biperiden, scopolamine, orphenadrine, and benzhexol/trihexyphenidyl (THP). (2) Methods: A systematic literature review was carried out using Pubmed, Scopus, and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Research methods were registered on PROSPERO (CRD42021257293). (3) Results: A total of 48 articles, including case reports, surveys, and retrospective case series analyses, were included. Most articles focused on benzhexol/THP (n = 25), and benztropine (n = 4). The routes of administration were mostly oral, and macrodoses together concomitant illicit drugs, e.g., cocaine, have been recorded. Toxidromes included both physical (e.g., tachycardia, tachypnoea, dilatated pupils, dry skin, urinary retention, ataxia, etc.) and psychiatric symptoms (e.g., anxiety, agitation, delirium, etc.). Fatal outcomes were very rare but reported. (4) Conclusion: Results from the present study show that anticholinergic misusing issues are both widespread worldwide and popular. Considering the potential adverse effects associated, healthcare professionals should be vigilant and monitor eventual misusing issues. |
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| Keywords: |
anticholinergic drugs; drug misuse; drug abuse; drug diversion |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Issue: |
2 |
| Start Page: |
355 |