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Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity

Rowan Durrant, Rodrigo Hamede, Konstans Wells Orcid Logo, Miguel Lurgi Rivera Orcid Logo

Pathogens, Volume: 10, Issue: 12, Start page: 1592

Swansea University Authors: Konstans Wells Orcid Logo, Miguel Lurgi Rivera Orcid Logo

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DOI (Published version): 10.3390/pathogens10121592

Abstract

Metapopulation structure plays a fundamental role in the persistence of wildlife populations. It can also drive the spread of infectious diseases and transmissible cancers such as the Tasmanian devil facial tumour disease (DFTD). While disrupting this structure can reduce disease spread, it can also...

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Published in: Pathogens
ISSN: 2076-0817
Published: MDPI AG 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa58980
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spelling 2021-12-29T15:17:20.0231201 v2 58980 2021-12-09 Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity d18166c31e89833c55ef0f2cbb551243 0000-0003-0377-2463 Konstans Wells Konstans Wells true false 947df89d116a1ab75515e421089e0443 0000-0001-9891-895X Miguel Lurgi Rivera Miguel Lurgi Rivera true false 2021-12-09 SBI Metapopulation structure plays a fundamental role in the persistence of wildlife populations. It can also drive the spread of infectious diseases and transmissible cancers such as the Tasmanian devil facial tumour disease (DFTD). While disrupting this structure can reduce disease spread, it can also impair host resilience by disrupting gene flow and colonisation dynamics. Using an individual-based metapopulation model we investigated the synergistic effects of host dispersal, disease transmission rate and inter-individual contact distance for transmission, on the spread and persistence of DFTD from local to regional scales. Disease spread, and the ensuing population declines, are synergistically determined by individuals’ dispersal, disease transmission rate and within-population mixing. Transmission rates can be magnified by high dispersal and inter-individual transmission distance. The isolation of local populations effectively reduced metapopulation-level disease prevalence but caused severe declines in metapopulation size and genetic diversity. The relative position of managed (i.e., isolated) local populations had a significant effect on disease prevalence, highlighting the importance of considering metapopulation structure when implementing metapopulation-scale disease control measures. Our findings suggest that population isolation is not an ideal management method for preventing disease spread in species inhabiting already fragmented landscapes, where genetic diversity and extinction risk are already a concern. Journal Article Pathogens 10 12 1592 MDPI AG 2076-0817 dispersal; contact distance; landscape-scale genetic diversity; disease transmission; disease management; metapopulation networks; metapopulation disease dynamics; fragmentation 8 12 2021 2021-12-08 10.3390/pathogens10121592 COLLEGE NANME Biosciences COLLEGE CODE SBI Swansea University 2021-12-29T15:17:20.0231201 2021-12-09T08:22:34.2934839 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Biosciences Rowan Durrant 1 Rodrigo Hamede 2 Konstans Wells 0000-0003-0377-2463 3 Miguel Lurgi Rivera 0000-0001-9891-895X 4 58980__21949__eb106f43ec5b4c5093e9e8aa786d8af8.pdf 58980.pdf 2021-12-29T14:52:30.5469518 Output 9507084 application/pdf Version of Record true © 2021 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license true eng https://creativecommons.org/licenses/by/4.0/
title Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity
spellingShingle Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity
Konstans Wells
Miguel Lurgi Rivera
title_short Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity
title_full Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity
title_fullStr Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity
title_full_unstemmed Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity
title_sort Disruption of Metapopulation Structure Reduces Tasmanian Devil Facial Tumour Disease Spread at the Expense of Abundance and Genetic Diversity
author_id_str_mv d18166c31e89833c55ef0f2cbb551243
947df89d116a1ab75515e421089e0443
author_id_fullname_str_mv d18166c31e89833c55ef0f2cbb551243_***_Konstans Wells
947df89d116a1ab75515e421089e0443_***_Miguel Lurgi Rivera
author Konstans Wells
Miguel Lurgi Rivera
author2 Rowan Durrant
Rodrigo Hamede
Konstans Wells
Miguel Lurgi Rivera
format Journal article
container_title Pathogens
container_volume 10
container_issue 12
container_start_page 1592
publishDate 2021
institution Swansea University
issn 2076-0817
doi_str_mv 10.3390/pathogens10121592
publisher MDPI AG
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Biosciences, Geography and Physics - Biosciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Biosciences, Geography and Physics - Biosciences
document_store_str 1
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description Metapopulation structure plays a fundamental role in the persistence of wildlife populations. It can also drive the spread of infectious diseases and transmissible cancers such as the Tasmanian devil facial tumour disease (DFTD). While disrupting this structure can reduce disease spread, it can also impair host resilience by disrupting gene flow and colonisation dynamics. Using an individual-based metapopulation model we investigated the synergistic effects of host dispersal, disease transmission rate and inter-individual contact distance for transmission, on the spread and persistence of DFTD from local to regional scales. Disease spread, and the ensuing population declines, are synergistically determined by individuals’ dispersal, disease transmission rate and within-population mixing. Transmission rates can be magnified by high dispersal and inter-individual transmission distance. The isolation of local populations effectively reduced metapopulation-level disease prevalence but caused severe declines in metapopulation size and genetic diversity. The relative position of managed (i.e., isolated) local populations had a significant effect on disease prevalence, highlighting the importance of considering metapopulation structure when implementing metapopulation-scale disease control measures. Our findings suggest that population isolation is not an ideal management method for preventing disease spread in species inhabiting already fragmented landscapes, where genetic diversity and extinction risk are already a concern.
published_date 2021-12-08T04:15:56Z
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