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The genetics of neuroticism and human values

George Zacharopoulos, Thomas M. Lancaster, Gregory R. Maio, David E. J. Linden

Genes, Brain and Behavior, Volume: 15, Issue: 4, Pages: 361 - 366

Swansea University Author: George Zacharopoulos

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DOI (Published version): 10.1111/gbb.12286

Abstract

Human values and personality have been shown to share genetic variance in twin studies. However, there is a lack of evidence about the genetic components of this association. This study examined the interplay between genes, values and personality in the case of neuroticism, because polygenic scores...

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Published in: Genes, Brain and Behavior
ISSN: 1601-1848
Published: Wiley 2016
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa58968
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Abstract: Human values and personality have been shown to share genetic variance in twin studies. However, there is a lack of evidence about the genetic components of this association. This study examined the interplay between genes, values and personality in the case of neuroticism, because polygenic scores were available for this personality trait. First, we replicated prior evidence of a positive association between the polygenic neuroticism score (PNS) and neuroticism. Second, we found that the PNS was significantly associated with the whole human value space in a sinusoidal waveform that was consistent with Schwartz's circular model of human values. These results suggest that it is useful to consider human values in the analyses of genetic contributions to personality traits. They also pave the way for an investigation of the biological mechanisms contributing to human value orientations.
Keywords: Genetics, human values, neuroticism, personality,polygenic score
College: Faculty of Medicine, Health and Life Sciences
Funders: National Centre for Mental Health (NCMH); National Institute for Social Care and Health Research (NISCHR); Welsh Government, Wales. Grant Number: BR09; Medical Research Council (MRC). Grant Number: MR/K004360/1; MRC Centre for Neuropsychiatric Genetics and Genomics. Grant Number: G0800509
Issue: 4
Start Page: 361
End Page: 366

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