A Hedonism Hub in the Human Brain

Zacharopoulos, George; Lancaster, T. M.; Bracht, T.; Ihssen, N.; Maio, G. R.; J., D. E.

doi:10.1093/cercor/bhw197

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A Hedonism Hub in the Human Brain

George Zacharopoulos, T. M. Lancaster, T. Bracht, N. Ihssen, G. R. Maio, D. E. J. Linden

Cerebral Cortex, Volume: 26, Issue: 10, Pages: 3921 - 3927

Swansea University Author: George Zacharopoulos

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DOI (Published version): 10.1093/cercor/bhw197

Abstract

Human values are abstract ideals that motivate behavior. The motivational nature of human values raises the possibility that they might be underpinned by brain structures that are particularly involved in motivated behavior and reward processing. We hypothesized that variation in subcortical hubs of...

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Published in:	Cerebral Cortex
ISSN:	1047-3211 1460-2199
Published:	Oxford University Press (OUP) 2016
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URI:	https://cronfa.swan.ac.uk/Record/cronfa58965
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spelling	2021-12-29T16:29:56.2549158 v2 58965 2021-12-07 A Hedonism Hub in the Human Brain 7abcfe5e6fd29d20e2c53eff9a4098d1 George Zacharopoulos George Zacharopoulos true false 2021-12-07 HPS Human values are abstract ideals that motivate behavior. The motivational nature of human values raises the possibility that they might be underpinned by brain structures that are particularly involved in motivated behavior and reward processing. We hypothesized that variation in subcortical hubs of the reward system and their main connecting pathway, the superolateral medial forebrain bundle (slMFB) is associated with individual value orientation. We conducted Pearson's correlation between the scores of 10 human values and the volumes of 14 subcortical structures and microstructural properties of the medial forebrain bundle in a sample of 87 participants, correcting for multiple comparisons (i.e.,190). We found a positive association between the value that people attach to hedonism and the volume of the left globus pallidus (GP).We then tested whether microstructural parameters (i.e., fractional anisotropy and myelin volume fraction) of the slMFB, which connects with the GP, are also associated to hedonism and found a significant, albeit in an uncorrected level, positive association between the myelin volume fraction within the left slMFB and hedonism scores. This is the first study to elucidate the relationship between the importance people attach to the human value of hedonism and structural variation in reward-related subcortical brain regions. Journal Article Cerebral Cortex 26 10 3921 3927 Oxford University Press (OUP) 1047-3211 1460-2199 globus pallidus, hedonism, human values, medial forebrain bundle 1 10 2016 2016-10-01 10.1093/cercor/bhw197 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University National Centre for Mental Health (NCMH) at Cardiff University, with funds from the National Institute for Social Care and Health Research (NISCHR), Welsh Government, Wales (Grant no. BR09), and by Grant MR/K004360/1 from the Medical Research Council (MRC) and by the MRC Centre for Neuropsychiatric Genetics and Genomics (G0800509) 2021-12-29T16:29:56.2549158 2021-12-07T14:30:50.6875302 Faculty of Medicine, Health and Life Sciences School of Psychology George Zacharopoulos 1 T. M. Lancaster 2 T. Bracht 3 N. Ihssen 4 G. R. Maio 5 D. E. J. Linden 6 58965__21953__c367c85b5613466eb796e5ed7a3523a7.pdf 58965.pdf 2021-12-29T16:27:57.9649105 Output 294752 application/pdf Version of Record true © The Author 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title	A Hedonism Hub in the Human Brain
spellingShingle	A Hedonism Hub in the Human Brain George Zacharopoulos
title_short	A Hedonism Hub in the Human Brain
title_full	A Hedonism Hub in the Human Brain
title_fullStr	A Hedonism Hub in the Human Brain
title_full_unstemmed	A Hedonism Hub in the Human Brain
title_sort	A Hedonism Hub in the Human Brain
author_id_str_mv	7abcfe5e6fd29d20e2c53eff9a4098d1
author_id_fullname_str_mv	7abcfe5e6fd29d20e2c53eff9a4098d1_***_George Zacharopoulos
author	George Zacharopoulos
author2	George Zacharopoulos T. M. Lancaster T. Bracht N. Ihssen G. R. Maio D. E. J. Linden
format	Journal article
container_title	Cerebral Cortex
container_volume	26
container_issue	10
container_start_page	3921
publishDate	2016
institution	Swansea University
issn	1047-3211 1460-2199
doi_str_mv	10.1093/cercor/bhw197
publisher	Oxford University Press (OUP)
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
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description	Human values are abstract ideals that motivate behavior. The motivational nature of human values raises the possibility that they might be underpinned by brain structures that are particularly involved in motivated behavior and reward processing. We hypothesized that variation in subcortical hubs of the reward system and their main connecting pathway, the superolateral medial forebrain bundle (slMFB) is associated with individual value orientation. We conducted Pearson's correlation between the scores of 10 human values and the volumes of 14 subcortical structures and microstructural properties of the medial forebrain bundle in a sample of 87 participants, correcting for multiple comparisons (i.e.,190). We found a positive association between the value that people attach to hedonism and the volume of the left globus pallidus (GP).We then tested whether microstructural parameters (i.e., fractional anisotropy and myelin volume fraction) of the slMFB, which connects with the GP, are also associated to hedonism and found a significant, albeit in an uncorrected level, positive association between the myelin volume fraction within the left slMFB and hedonism scores. This is the first study to elucidate the relationship between the importance people attach to the human value of hedonism and structural variation in reward-related subcortical brain regions.
published_date	2016-10-01T04:15:54Z
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A Hedonism Hub in the Human Brain

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