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The cross‐sectional interplay between neurochemical profile and brain connectivity

George Zacharopoulos Orcid Logo, Uzay Emir, Roi Cohen Kadosh

Human Brain Mapping, Volume: 42, Issue: 9, Pages: 2722 - 2733

Swansea University Author: George Zacharopoulos Orcid Logo

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DOI (Published version): 10.1002/hbm.25396

Abstract

Neurochemical profile and brain connectivity are both critical aspects of brain function. However, our knowledge of their interplay across development is currently poor. We combined single-voxel magnetic resonance spectroscopy and resting functional magnetic resonance imaging in a cross-sectional sa...

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Published in: Human Brain Mapping
ISSN: 1065-9471 1097-0193
Published: Wiley 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa58961
first_indexed 2021-12-07T14:34:00Z
last_indexed 2024-11-14T12:14:37Z
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spelling 2023-09-13T17:16:34.9329882 v2 58961 2021-12-07 The cross‐sectional interplay between neurochemical profile and brain connectivity 7abcfe5e6fd29d20e2c53eff9a4098d1 0000-0003-0574-866X George Zacharopoulos George Zacharopoulos true false 2021-12-07 PSYS Neurochemical profile and brain connectivity are both critical aspects of brain function. However, our knowledge of their interplay across development is currently poor. We combined single-voxel magnetic resonance spectroscopy and resting functional magnetic resonance imaging in a cross-sectional sample spanning from childhood to adulthood which was reassessed in ~1.5 years (N = 293). We revealed the developmental trajectories of 20 neurochemicals in two key developmental brain regions (the intraparietal sulcus, IPS, and the middle frontal gyrus, MFG). We found that certain neurochemicals exhibited similar developmental trajectories across the two regions, while other trajectories were region-specific. Crucially, we mapped the connectivity of the brain regions IPS and MFG to the rest of the brain across development as a function of regional glutamate and GABA concentration. We demonstrated that glutamate concentration within the IPS is modulated by age in explaining IPS connectivity with frontal, temporal and parietal regions. In mature participants, higher glutamate within the IPS was related to more negative connectivity while the opposite pattern was found for younger participants. Our findings offer specific developmental insights on the interplay between the brain's resting activity and the glutamatergic system both of which are crucial for regulating normal functioning and are dysregulated in several clinical conditions. Journal Article Human Brain Mapping 42 9 2722 2733 Wiley 1065-9471 1097-0193 brain connectivity; development; glutamate; neurochemicals; parietal 15 6 2021 2021-06-15 10.1002/hbm.25396 COLLEGE NANME Psychology School COLLEGE CODE PSYS Swansea University FP7 Ideas: European Research Council. Grant Number: 338065; Wellcome Trust. Grant Number: 203139/Z/16/Z 2023-09-13T17:16:34.9329882 2021-12-07T14:28:21.2146430 Faculty of Medicine, Health and Life Sciences School of Psychology George Zacharopoulos 0000-0003-0574-866X 1 Uzay Emir 2 Roi Cohen Kadosh 3 58961__21962__619a25ccf657410fbd3f2b5874bec49a.pdf 58961.pdf 2021-12-30T10:08:06.0451087 Output 3816728 application/pdf Version of Record true © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title The cross‐sectional interplay between neurochemical profile and brain connectivity
spellingShingle The cross‐sectional interplay between neurochemical profile and brain connectivity
George Zacharopoulos
title_short The cross‐sectional interplay between neurochemical profile and brain connectivity
title_full The cross‐sectional interplay between neurochemical profile and brain connectivity
title_fullStr The cross‐sectional interplay between neurochemical profile and brain connectivity
title_full_unstemmed The cross‐sectional interplay between neurochemical profile and brain connectivity
title_sort The cross‐sectional interplay between neurochemical profile and brain connectivity
author_id_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1
author_id_fullname_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1_***_George Zacharopoulos
author George Zacharopoulos
author2 George Zacharopoulos
Uzay Emir
Roi Cohen Kadosh
format Journal article
container_title Human Brain Mapping
container_volume 42
container_issue 9
container_start_page 2722
publishDate 2021
institution Swansea University
issn 1065-9471
1097-0193
doi_str_mv 10.1002/hbm.25396
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
active_str 0
description Neurochemical profile and brain connectivity are both critical aspects of brain function. However, our knowledge of their interplay across development is currently poor. We combined single-voxel magnetic resonance spectroscopy and resting functional magnetic resonance imaging in a cross-sectional sample spanning from childhood to adulthood which was reassessed in ~1.5 years (N = 293). We revealed the developmental trajectories of 20 neurochemicals in two key developmental brain regions (the intraparietal sulcus, IPS, and the middle frontal gyrus, MFG). We found that certain neurochemicals exhibited similar developmental trajectories across the two regions, while other trajectories were region-specific. Crucially, we mapped the connectivity of the brain regions IPS and MFG to the rest of the brain across development as a function of regional glutamate and GABA concentration. We demonstrated that glutamate concentration within the IPS is modulated by age in explaining IPS connectivity with frontal, temporal and parietal regions. In mature participants, higher glutamate within the IPS was related to more negative connectivity while the opposite pattern was found for younger participants. Our findings offer specific developmental insights on the interplay between the brain's resting activity and the glutamatergic system both of which are crucial for regulating normal functioning and are dysregulated in several clinical conditions.
published_date 2021-06-15T05:12:08Z
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