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Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study

Lynn Calman, Joshua Turner, Deborah Fenlon, Natalia V. Permyakova, Sally Wheelwright, Mubarak Patel, Amy Din, Jane Winter, Alison Richardson, Peter W. F. Smith, Claire Foster, (The CREW Study Advisory Committee)

Colorectal Disease, Volume: 23, Issue: 12

Swansea University Author: Deborah Fenlon

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DOI (Published version): 10.1111/codi.15949

Abstract

Depression experienced by people with colorectal cancer (CRC) is an important clinical problem affecting quality of life. Recognition at key points in the pathway enables timely referral to support. This study aimed to examine depression pre- and 5 years post-surgery to examine its prevalence and id...

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Published in: Colorectal Disease
ISSN: 1462-8910 1463-1318
Published: Wiley 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa58569
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spelling v2 58569 2021-11-08 Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study efa6c181fe0a6e5c923b1126ce469186 Deborah Fenlon Deborah Fenlon true false 2021-11-08 FGMHL Depression experienced by people with colorectal cancer (CRC) is an important clinical problem affecting quality of life. Recognition at key points in the pathway enables timely referral to support. This study aimed to examine depression pre- and 5 years post-surgery to examine its prevalence and identify determinants. The ColoREctal Wellbeing (CREW) study is a prospective UK cohort involving 872 adults with non-metastatic CRC recruited before curative-intent surgery. Questionnaires completed pre-surgery, and 3, 9, 15, 24, 36, 48 and 60 months post-surgery, captured socio-demographics, assessed depression (Centre for Epidemiologic Studies Depression Scale, CES-D) and other psychosocial factors. Clinical details were also gathered. We present prevalence of clinically significant depression (CES-D≥20) over time and its predictors assessed pre-surgery and 2 years post-surgery. Pre-surgery, 21.0% of the cohort reported CES-D≥20 reducing to 14.7% 5 years post-surgery. Pre-surgery risk factors predicting subsequent depression were clinically significant depression and anxiety, previous mental health service use, low self-efficacy, poor health, having neoadjuvant treatment and low social support. Post-surgery risk factors at 2 years predicting subsequent depression were clinically significant depression, negative affect, cognitive dysfunction, accommodation type and poor health. Depression is highly pervasive in people with CRC, exceeding general population prevalence across follow-up. Our findings emphasise the need to screen and treat depression across the pathway. Our novel data highlight key risk factors of later depression at important and opportune time points: pre-surgery and the end of routine surveillance. Early recognition and timely referral to appropriate support is vital to improve long-term psychological outcomes. [Abstract copyright: This article is protected by copyright. All rights reserved.] Journal Article Colorectal Disease 23 12 Wiley 1462-8910 1463-1318 colorectal cancer; determinants; depression; quality of life; risk factors 25 11 2021 2021-11-25 10.1111/codi.15949 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University Macmillan Cancer Support as part of the Macmillan Survivorship Research Group programme (grant no. 3546834). 2023-06-28T15:44:58.5611403 2021-11-08T10:41:35.3192155 Faculty of Medicine, Health and Life Sciences School of Health and Social Care - Nursing Lynn Calman 1 Joshua Turner 2 Deborah Fenlon 3 Natalia V. Permyakova 4 Sally Wheelwright 5 Mubarak Patel 6 Amy Din 7 Jane Winter 8 Alison Richardson 9 Peter W. F. Smith 10 Claire Foster 11 (The CREW Study Advisory Committee) 12 58569__21697__34672f1bb9884c598f9f404c0c13072f.pdf 58569.pdf 2021-11-26T10:55:57.6041507 Output 785917 application/pdf Version of Record true © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study
spellingShingle Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study
Deborah Fenlon
title_short Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study
title_full Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study
title_fullStr Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study
title_full_unstemmed Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study
title_sort Prevalence and determinants of depression up to 5 years after colorectal cancer surgery: Results from the ColoREctal Wellbeing (CREW) study
author_id_str_mv efa6c181fe0a6e5c923b1126ce469186
author_id_fullname_str_mv efa6c181fe0a6e5c923b1126ce469186_***_Deborah Fenlon
author Deborah Fenlon
author2 Lynn Calman
Joshua Turner
Deborah Fenlon
Natalia V. Permyakova
Sally Wheelwright
Mubarak Patel
Amy Din
Jane Winter
Alison Richardson
Peter W. F. Smith
Claire Foster
(The CREW Study Advisory Committee)
format Journal article
container_title Colorectal Disease
container_volume 23
container_issue 12
publishDate 2021
institution Swansea University
issn 1462-8910
1463-1318
doi_str_mv 10.1111/codi.15949
publisher Wiley
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Health and Social Care - Nursing{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Health and Social Care - Nursing
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description Depression experienced by people with colorectal cancer (CRC) is an important clinical problem affecting quality of life. Recognition at key points in the pathway enables timely referral to support. This study aimed to examine depression pre- and 5 years post-surgery to examine its prevalence and identify determinants. The ColoREctal Wellbeing (CREW) study is a prospective UK cohort involving 872 adults with non-metastatic CRC recruited before curative-intent surgery. Questionnaires completed pre-surgery, and 3, 9, 15, 24, 36, 48 and 60 months post-surgery, captured socio-demographics, assessed depression (Centre for Epidemiologic Studies Depression Scale, CES-D) and other psychosocial factors. Clinical details were also gathered. We present prevalence of clinically significant depression (CES-D≥20) over time and its predictors assessed pre-surgery and 2 years post-surgery. Pre-surgery, 21.0% of the cohort reported CES-D≥20 reducing to 14.7% 5 years post-surgery. Pre-surgery risk factors predicting subsequent depression were clinically significant depression and anxiety, previous mental health service use, low self-efficacy, poor health, having neoadjuvant treatment and low social support. Post-surgery risk factors at 2 years predicting subsequent depression were clinically significant depression, negative affect, cognitive dysfunction, accommodation type and poor health. Depression is highly pervasive in people with CRC, exceeding general population prevalence across follow-up. Our findings emphasise the need to screen and treat depression across the pathway. Our novel data highlight key risk factors of later depression at important and opportune time points: pre-surgery and the end of routine surveillance. Early recognition and timely referral to appropriate support is vital to improve long-term psychological outcomes. [Abstract copyright: This article is protected by copyright. All rights reserved.]
published_date 2021-11-25T15:44:54Z
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