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Numerical Study of Lymph Mechanics / DANIEL WATSON

Swansea University Author: DANIEL WATSON

DOI (Published version): 10.23889/SUthesis.58474

Abstract

Methods taken from engineering and computer science were applied to the lymphatic system. Starting with a 3D analysis of a single subject-specific lymphatic valve. A mechanism was presented to explain previous experimental results showing the effect of trans-mural pressure on the pressure required to...

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Published: Swansea 2021
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
Supervisor: van Loon, Raoul
URI: https://cronfa.swan.ac.uk/Record/cronfa58474
first_indexed 2021-10-27T12:15:23Z
last_indexed 2021-10-28T03:23:39Z
id cronfa58474
recordtype RisThesis
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spelling 2021-10-27T13:37:26.3097225 v2 58474 2021-10-27 Numerical Study of Lymph Mechanics 4072729957075a91f1b29d1579d38b38 DANIEL WATSON DANIEL WATSON true false 2021-10-27 Methods taken from engineering and computer science were applied to the lymphatic system. Starting with a 3D analysis of a single subject-specific lymphatic valve. A mechanism was presented to explain previous experimental results showing the effect of trans-mural pressure on the pressure required to close lymphatic valves. The impor-tance of wall motion in future FSI studies of lymphatic valve dynamics were identified. Previous approaches to lumped modelling of the lymphatic system were considered and modifications were proposed. A less-idealised valve model, incorporating trans-mural dependent bias, was proposed as well as a method of allowing self-organised contrac-tion through a stretch-dependent frequency of contraction. A network of the superficial lymphatics of the upper-limb was reconstructed from an anatomical sketch. The net-work was used in conjunction with the lumped model to produce a 421 vessel lymphatic model consisting of 17,706 lymphangions. Several issues which impede large network scale modelling of the lymphatic system are identified. A simplified patient-specific biphasic model of lymphoedema was proposed and used to develop a novel shape-based metric for lymphoedema. A statistically significant relationship between the metric and the presence of lymphoedema was found. E-Thesis Swansea Lymphatics, 0D Modelling, Shape Analysis 27 10 2021 2021-10-27 10.23889/SUthesis.58474 ORCiD identifier https://orcid.org/0000-0001-7841-6637 COLLEGE NANME COLLEGE CODE Swansea University van Loon, Raoul Doctoral Ph.D EPRSC, grant number - 1696351 2021-10-27T13:37:26.3097225 2021-10-27T13:12:21.5217818 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised DANIEL WATSON 1 58474__21319__dd801f36ba2748ff9b9ebe3cdb48e5d5.pdf Watson_Daniel_J_PhD_Thesis_Final_Redacted_Signature.pdf 2021-10-27T13:30:18.1260318 Output 20802123 application/pdf E-Thesis – open access true Copyright: The author, Daniel J. Watson, 2021. true eng
title Numerical Study of Lymph Mechanics
spellingShingle Numerical Study of Lymph Mechanics
DANIEL WATSON
title_short Numerical Study of Lymph Mechanics
title_full Numerical Study of Lymph Mechanics
title_fullStr Numerical Study of Lymph Mechanics
title_full_unstemmed Numerical Study of Lymph Mechanics
title_sort Numerical Study of Lymph Mechanics
author_id_str_mv 4072729957075a91f1b29d1579d38b38
author_id_fullname_str_mv 4072729957075a91f1b29d1579d38b38_***_DANIEL WATSON
author DANIEL WATSON
author2 DANIEL WATSON
format E-Thesis
publishDate 2021
institution Swansea University
doi_str_mv 10.23889/SUthesis.58474
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 1
active_str 0
description Methods taken from engineering and computer science were applied to the lymphatic system. Starting with a 3D analysis of a single subject-specific lymphatic valve. A mechanism was presented to explain previous experimental results showing the effect of trans-mural pressure on the pressure required to close lymphatic valves. The impor-tance of wall motion in future FSI studies of lymphatic valve dynamics were identified. Previous approaches to lumped modelling of the lymphatic system were considered and modifications were proposed. A less-idealised valve model, incorporating trans-mural dependent bias, was proposed as well as a method of allowing self-organised contrac-tion through a stretch-dependent frequency of contraction. A network of the superficial lymphatics of the upper-limb was reconstructed from an anatomical sketch. The net-work was used in conjunction with the lumped model to produce a 421 vessel lymphatic model consisting of 17,706 lymphangions. Several issues which impede large network scale modelling of the lymphatic system are identified. A simplified patient-specific biphasic model of lymphoedema was proposed and used to develop a novel shape-based metric for lymphoedema. A statistically significant relationship between the metric and the presence of lymphoedema was found.
published_date 2021-10-27T05:50:32Z
_version_ 1830348791422648320
score 11.317152

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