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Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International,...

Wojciech Kuczyński, Erik Wibowo, Tetsuro Hoshino, Aleksandra Kudrycka, Aleksandra Małolepsza, Urszula Karwowska, Milena Pruszkowska, Jakub Wasiak, Aleksandra Kuczyńska, Jakub Spałka, Paulina Pruszkowska-Przybylska, Łukasz Mokros, Adam Białas, Piotr Białasiewicz, Ryujiro Sasanabe, Mark Blagrove Orcid Logo, John Manning

JMIR Research Protocols, Volume: 10, Issue: 10, Start page: e29199

Swansea University Authors: Mark Blagrove Orcid Logo, John Manning

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DOI (Published version): 10.2196/29199

Abstract

The ratio of the second finger length to the fourth finger length (2D:4D ratio) is considered to be negatively correlated with prenatal androgen exposure (PAE) and positively correlated with prenatal estrogen. Coincidentally, various brain regions are sensitive to PAE, and their functions in adults...

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Published in: JMIR Research Protocols
ISSN: 1929-0748 1929-0748
Published: JMIR Publications Inc. 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa58433
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Coincidentally, various brain regions are sensitive to PAE, and their functions in adults may be influenced by the prenatal actions of sex hormones. This study aims to assess the relationship between PAE (indicated by the 2D:4D ratio) and various physiological (sex hormone levels and sleep-wake parameters), psychological (mental health), and sexual parameters in healthy young adults. This study consists of two phases. In phase 1, we will conduct a survey-based study and anthropometric assessments (including 2D:4D ratio and BMI) in healthy young adults. Using validated questionnaires, we will collect self-reported data on sleep quality, sexual function, sleep chronotype, anxiety, and depressive symptoms. In phase 2, a subsample of phase 1 will undergo polysomnography and physiological and genetic assessments. Sleep architecture data will be obtained using portable polysomnography. The levels of testosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, melatonin, and circadian regulatory proteins (circadian locomotor output cycles kaput [CLOCK], timeless [TIM], and period [PER]) and the expression levels of some miRNAs will be measured using blood samples. The rest and activity cycle will be monitored using actigraphy for a 7-day period. In Poland, 720 participants were recruited for phase 1. Among these, 140 completed anthropometric measurements. In addition, 25 participants joined and completed phase 2 data collection. Recruitment from other sites will follow. Findings from our study may help to better understand the plausible role of PAE in sleep physiology, mental health, and sexual quality of life in young adults. DERR1-10.2196/29199. 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spelling 2021-11-17T16:32:36.3089725 v2 58433 2021-10-20 Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study 8c78ee008e650b9f0a463bae56a5636c 0000-0002-9854-1854 Mark Blagrove Mark Blagrove true false d106a326bbb29a053d2b8c7f8ad9a3f8 John Manning John Manning true false 2021-10-20 HPS The ratio of the second finger length to the fourth finger length (2D:4D ratio) is considered to be negatively correlated with prenatal androgen exposure (PAE) and positively correlated with prenatal estrogen. Coincidentally, various brain regions are sensitive to PAE, and their functions in adults may be influenced by the prenatal actions of sex hormones. This study aims to assess the relationship between PAE (indicated by the 2D:4D ratio) and various physiological (sex hormone levels and sleep-wake parameters), psychological (mental health), and sexual parameters in healthy young adults. This study consists of two phases. In phase 1, we will conduct a survey-based study and anthropometric assessments (including 2D:4D ratio and BMI) in healthy young adults. Using validated questionnaires, we will collect self-reported data on sleep quality, sexual function, sleep chronotype, anxiety, and depressive symptoms. In phase 2, a subsample of phase 1 will undergo polysomnography and physiological and genetic assessments. Sleep architecture data will be obtained using portable polysomnography. The levels of testosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, melatonin, and circadian regulatory proteins (circadian locomotor output cycles kaput [CLOCK], timeless [TIM], and period [PER]) and the expression levels of some miRNAs will be measured using blood samples. The rest and activity cycle will be monitored using actigraphy for a 7-day period. In Poland, 720 participants were recruited for phase 1. Among these, 140 completed anthropometric measurements. In addition, 25 participants joined and completed phase 2 data collection. Recruitment from other sites will follow. Findings from our study may help to better understand the plausible role of PAE in sleep physiology, mental health, and sexual quality of life in young adults. DERR1-10.2196/29199. [Abstract copyright: ©Wojciech Kuczyński, Erik Wibowo, Tetsuro Hoshino, Aleksandra Kudrycka, Aleksandra Małolepsza, Urszula Karwowska, Milena Pruszkowska, Jakub Wasiak, Aleksandra Kuczyńska, Jakub Spałka, Paulina Pruszkowska-Przybylska, Łukasz Mokros, Adam Białas, Piotr Białasiewicz, Ryujiro Sasanabe, Mark Blagrove, John Manning. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 06.10.2021.] Journal Article JMIR Research Protocols 10 10 e29199 JMIR Publications Inc. 1929-0748 1929-0748 chronotype, sex hormones, circadian proteins, miRNA, sleep, testosterone, estrogen, digit ratio, circadian rhythm 6 10 2021 2021-10-06 10.2196/29199 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University 2021-11-17T16:32:36.3089725 2021-10-20T13:09:50.0589003 Faculty of Medicine, Health and Life Sciences School of Psychology Wojciech Kuczyński 1 Erik Wibowo 2 Tetsuro Hoshino 3 Aleksandra Kudrycka 4 Aleksandra Małolepsza 5 Urszula Karwowska 6 Milena Pruszkowska 7 Jakub Wasiak 8 Aleksandra Kuczyńska 9 Jakub Spałka 10 Paulina Pruszkowska-Przybylska 11 Łukasz Mokros 12 Adam Białas 13 Piotr Białasiewicz 14 Ryujiro Sasanabe 15 Mark Blagrove 0000-0002-9854-1854 16 John Manning 17 58433__21238__8336f25c05674822a994c753b6b7e181.pdf 58433.pdf 2021-10-20T13:13:56.1747496 Output 614455 application/pdf Version of Record true This is an open-access article distributed under the terms of the Creative Commons Attribution License true eng https://creativecommons.org/licenses/by/4.0/
title Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study
spellingShingle Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study
Mark Blagrove
John Manning
title_short Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study
title_full Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study
title_fullStr Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study
title_full_unstemmed Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study
title_sort Understanding the Associations of Prenatal Androgen Exposure on Sleep Physiology, Circadian Proteins, Anthropometric Parameters, Hormonal Factors, Quality of Life, and Sex Among Healthy Young Adults: Protocol for an International, Multicenter Study
author_id_str_mv 8c78ee008e650b9f0a463bae56a5636c
d106a326bbb29a053d2b8c7f8ad9a3f8
author_id_fullname_str_mv 8c78ee008e650b9f0a463bae56a5636c_***_Mark Blagrove
d106a326bbb29a053d2b8c7f8ad9a3f8_***_John Manning
author Mark Blagrove
John Manning
author2 Wojciech Kuczyński
Erik Wibowo
Tetsuro Hoshino
Aleksandra Kudrycka
Aleksandra Małolepsza
Urszula Karwowska
Milena Pruszkowska
Jakub Wasiak
Aleksandra Kuczyńska
Jakub Spałka
Paulina Pruszkowska-Przybylska
Łukasz Mokros
Adam Białas
Piotr Białasiewicz
Ryujiro Sasanabe
Mark Blagrove
John Manning
format Journal article
container_title JMIR Research Protocols
container_volume 10
container_issue 10
container_start_page e29199
publishDate 2021
institution Swansea University
issn 1929-0748
1929-0748
doi_str_mv 10.2196/29199
publisher JMIR Publications Inc.
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
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description The ratio of the second finger length to the fourth finger length (2D:4D ratio) is considered to be negatively correlated with prenatal androgen exposure (PAE) and positively correlated with prenatal estrogen. Coincidentally, various brain regions are sensitive to PAE, and their functions in adults may be influenced by the prenatal actions of sex hormones. This study aims to assess the relationship between PAE (indicated by the 2D:4D ratio) and various physiological (sex hormone levels and sleep-wake parameters), psychological (mental health), and sexual parameters in healthy young adults. This study consists of two phases. In phase 1, we will conduct a survey-based study and anthropometric assessments (including 2D:4D ratio and BMI) in healthy young adults. Using validated questionnaires, we will collect self-reported data on sleep quality, sexual function, sleep chronotype, anxiety, and depressive symptoms. In phase 2, a subsample of phase 1 will undergo polysomnography and physiological and genetic assessments. Sleep architecture data will be obtained using portable polysomnography. The levels of testosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, melatonin, and circadian regulatory proteins (circadian locomotor output cycles kaput [CLOCK], timeless [TIM], and period [PER]) and the expression levels of some miRNAs will be measured using blood samples. The rest and activity cycle will be monitored using actigraphy for a 7-day period. In Poland, 720 participants were recruited for phase 1. Among these, 140 completed anthropometric measurements. In addition, 25 participants joined and completed phase 2 data collection. Recruitment from other sites will follow. Findings from our study may help to better understand the plausible role of PAE in sleep physiology, mental health, and sexual quality of life in young adults. DERR1-10.2196/29199. [Abstract copyright: ©Wojciech Kuczyński, Erik Wibowo, Tetsuro Hoshino, Aleksandra Kudrycka, Aleksandra Małolepsza, Urszula Karwowska, Milena Pruszkowska, Jakub Wasiak, Aleksandra Kuczyńska, Jakub Spałka, Paulina Pruszkowska-Przybylska, Łukasz Mokros, Adam Białas, Piotr Białasiewicz, Ryujiro Sasanabe, Mark Blagrove, John Manning. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 06.10.2021.]
published_date 2021-10-06T04:14:57Z
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score 11.013776

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