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Predicting learning and achievement using GABA and glutamate concentrations in human development

George Zacharopoulos, Francesco Sella, Kathrin Cohen Kadosh, Charlotte Hartwright, Uzay Emir, Roi Cohen Kadosh

PLOS Biology, Volume: 19, Issue: 7, Start page: e3001325

Swansea University Author: George Zacharopoulos

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DOI (Published version): 10.1371/journal.pbio.3001325

Abstract

Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in learning and plasticity. What is currently unknown is how this knowledge translates to real-life complex cognitive abilities that emerge slowly and how the link between these neurotransmitters and human lea...

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Published in: PLOS Biology
ISSN: 1545-7885
Published: Public Library of Science (PLoS) 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa58269
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first_indexed 2021-10-08T10:46:05Z
last_indexed 2023-01-11T14:38:45Z
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spelling 2022-10-25T15:42:01.3397588 v2 58269 2021-10-08 Predicting learning and achievement using GABA and glutamate concentrations in human development 7abcfe5e6fd29d20e2c53eff9a4098d1 George Zacharopoulos George Zacharopoulos true false 2021-10-08 HPS Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in learning and plasticity. What is currently unknown is how this knowledge translates to real-life complex cognitive abilities that emerge slowly and how the link between these neurotransmitters and human learning and plasticity is shaped by development. While some have suggested a generic role of glutamate and GABA in learning and plasticity, others have hypothesized that their involvement shapes sensitive periods during development. Here we used a cross-sectional longitudinal design with 255 individuals (spanning primary school to university) to show that glutamate and GABA in the intraparietal sulcus explain unique variance both in current and future mathematical achievement (approximately 1.5 years). Furthermore, our findings reveal a dynamic and dissociable role of GABA and glutamate in predicting learning, which is reversed during development, and therefore provide novel implications for models of learning and plasticity during childhood and adulthood. Journal Article PLOS Biology 19 7 e3001325 Public Library of Science (PLoS) 1545-7885 22 7 2021 2021-07-22 10.1371/journal.pbio.3001325 COLLEGE NANME Psychology COLLEGE CODE HPS Swansea University Wellcome Trust (203139/Z/16/Z); European Research Council (Learning&Achievement 338065) 2022-10-25T15:42:01.3397588 2021-10-08T11:42:55.3467031 Faculty of Medicine, Health and Life Sciences School of Psychology George Zacharopoulos 1 Francesco Sella 2 Kathrin Cohen Kadosh 3 Charlotte Hartwright 4 Uzay Emir 5 Roi Cohen Kadosh 6 58269__21366__34c5ba2446ee48688c559a36a7bbb3f6.pdf 58269.pdf 2021-10-29T11:59:30.7400732 Output 1961721 application/pdf Version of Record true © 2021 Zacharopoulos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Predicting learning and achievement using GABA and glutamate concentrations in human development
spellingShingle Predicting learning and achievement using GABA and glutamate concentrations in human development
George Zacharopoulos
title_short Predicting learning and achievement using GABA and glutamate concentrations in human development
title_full Predicting learning and achievement using GABA and glutamate concentrations in human development
title_fullStr Predicting learning and achievement using GABA and glutamate concentrations in human development
title_full_unstemmed Predicting learning and achievement using GABA and glutamate concentrations in human development
title_sort Predicting learning and achievement using GABA and glutamate concentrations in human development
author_id_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1
author_id_fullname_str_mv 7abcfe5e6fd29d20e2c53eff9a4098d1_***_George Zacharopoulos
author George Zacharopoulos
author2 George Zacharopoulos
Francesco Sella
Kathrin Cohen Kadosh
Charlotte Hartwright
Uzay Emir
Roi Cohen Kadosh
format Journal article
container_title PLOS Biology
container_volume 19
container_issue 7
container_start_page e3001325
publishDate 2021
institution Swansea University
issn 1545-7885
doi_str_mv 10.1371/journal.pbio.3001325
publisher Public Library of Science (PLoS)
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str School of Psychology{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}School of Psychology
document_store_str 1
active_str 0
description Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in learning and plasticity. What is currently unknown is how this knowledge translates to real-life complex cognitive abilities that emerge slowly and how the link between these neurotransmitters and human learning and plasticity is shaped by development. While some have suggested a generic role of glutamate and GABA in learning and plasticity, others have hypothesized that their involvement shapes sensitive periods during development. Here we used a cross-sectional longitudinal design with 255 individuals (spanning primary school to university) to show that glutamate and GABA in the intraparietal sulcus explain unique variance both in current and future mathematical achievement (approximately 1.5 years). Furthermore, our findings reveal a dynamic and dissociable role of GABA and glutamate in predicting learning, which is reversed during development, and therefore provide novel implications for models of learning and plasticity during childhood and adulthood.
published_date 2021-07-22T04:14:40Z
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score 11.013731

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