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Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK

Yvonne Moriarty, Mandy Lau, Berni Sewell Orcid Logo, Rob Trubey, Harriet Quinn-Scoggins, Sioned Owen, Louise Padgett, Vasiliki Kolovou, Julie Hepburn, Peter Buckle, Rebecca Playle, Julia Townson, Michael Robling, Stephanie Gilbert, Polyxeni Dimitropoulou, Adrian Edwards, Caroline Mitchell, Maura Matthews, Stephanie Smits, Fiona Wood, Richard D. Neal, Kate Brain, Mari Jones Orcid Logo, Angela Farr Orcid Logo, (ABACus study team)

British Journal of Cancer, Volume: 125, Issue: 8, Pages: 1100 - 1110

Swansea University Authors: Berni Sewell Orcid Logo, Mari Jones Orcid Logo, Angela Farr Orcid Logo

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DOI (Published version): 10.1038/s41416-021-01524-5

Abstract

BackgroundCancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation.MethodsThis is a randomised controlled trial involving adults aged 40+ year...

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Published in: British Journal of Cancer
ISSN: 0007-0920 1532-1827
Published: Springer Science and Business Media LLC 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa57888
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fullrecord <?xml version="1.0" encoding="utf-8"?><rfc1807 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><bib-version>v2</bib-version><id>57888</id><entry>2021-09-14</entry><title>Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK</title><swanseaauthors><author><sid>f6a4af2cfa4275d2a8ebba292fa14421</sid><ORCID>0000-0001-5471-922X</ORCID><firstname>Berni</firstname><surname>Sewell</surname><name>Berni Sewell</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>8e326860810f5f960b088db10ef58906</sid><ORCID>0000-0001-9661-4899</ORCID><firstname>Mari</firstname><surname>Jones</surname><name>Mari Jones</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>ab00dbaa888f32b41b07ef223d0e2987</sid><ORCID>0000-0002-2087-9310</ORCID><firstname>Angela</firstname><surname>Farr</surname><name>Angela Farr</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2021-09-14</date><deptcode>PHAC</deptcode><abstract>BackgroundCancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation.MethodsThis is a randomised controlled trial involving adults aged 40+ years recruited in community and healthcare settings in deprived areas of South Yorkshire and South-East Wales. Intervention: personalised behavioural advice facilitated by a trained lay advisor. Control: usual care. Follow-up at two weeks and six months post-randomisation. Primary outcome: total cancer symptom recognition score two weeks post-randomisation.ResultsTwo hundred and thirty-four participants were randomised. The difference in total symptom recognition at two weeks [adjusted mean difference (AMD) 0.6, 95% CI: −0.03, 1.17, p = 0.06] was not statistically significant. Intervention participants reported increased symptom recognition (AMD 0.8, 95% CI: 0.18, 1.37, p = 0.01) and earlier intended presentation (AMD −2.0, 95% CI: −3.02, −0.91, p &lt; 0.001) at six months. “Lesser known” symptom recognition was higher in the intervention arm (2 weeks AMD 0.5, 95% CI: 0.03, 0.97 and six months AMD 0.7, 95% CI: 0.16, 1.17). Implementation cost per participant was £91.34, with no significant between-group differences in healthcare resource use post-intervention.ConclusionsImproved symptom recognition and earlier anticipated presentation occurred at longer-term follow-up. The ABACus Health Check is a viable low-cost intervention to increase cancer awareness in socioeconomically deprived communities.</abstract><type>Journal Article</type><journal>British Journal of Cancer</journal><volume>125</volume><journalNumber>8</journalNumber><paginationStart>1100</paginationStart><paginationEnd>1110</paginationEnd><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0007-0920</issnPrint><issnElectronic>1532-1827</issnElectronic><keywords/><publishedDay>12</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-10-12</publishedDate><doi>10.1038/s41416-021-01524-5</doi><url/><notes/><college>COLLEGE NANME</college><department>Public Health</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>PHAC</DepartmentCode><institution>Swansea University</institution><apcterm/><funders>This work was supported by Yorkshire Cancer Research grant number C402. This research comes under the auspices of the Health and Care Research Wales funded by Primary and Emergency Care Research Centre (PRIME) [517195] and Wales Cancer Research Centre [517190]. The Centre for Trials Research (CTR) is funded through the Welsh Government by Health and Care Research Wales and Cancer Research UK.</funders><projectreference/><lastEdited>2023-09-13T16:43:38.2921043</lastEdited><Created>2021-09-14T14:03:55.6933942</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2"/></path><authors><author><firstname>Yvonne</firstname><surname>Moriarty</surname><order>1</order></author><author><firstname>Mandy</firstname><surname>Lau</surname><order>2</order></author><author><firstname>Berni</firstname><surname>Sewell</surname><orcid>0000-0001-5471-922X</orcid><order>3</order></author><author><firstname>Rob</firstname><surname>Trubey</surname><order>4</order></author><author><firstname>Harriet</firstname><surname>Quinn-Scoggins</surname><order>5</order></author><author><firstname>Sioned</firstname><surname>Owen</surname><order>6</order></author><author><firstname>Louise</firstname><surname>Padgett</surname><order>7</order></author><author><firstname>Vasiliki</firstname><surname>Kolovou</surname><order>8</order></author><author><firstname>Julie</firstname><surname>Hepburn</surname><order>9</order></author><author><firstname>Peter</firstname><surname>Buckle</surname><order>10</order></author><author><firstname>Rebecca</firstname><surname>Playle</surname><order>11</order></author><author><firstname>Julia</firstname><surname>Townson</surname><order>12</order></author><author><firstname>Michael</firstname><surname>Robling</surname><order>13</order></author><author><firstname>Stephanie</firstname><surname>Gilbert</surname><order>14</order></author><author><firstname>Polyxeni</firstname><surname>Dimitropoulou</surname><order>15</order></author><author><firstname>Adrian</firstname><surname>Edwards</surname><order>16</order></author><author><firstname>Caroline</firstname><surname>Mitchell</surname><order>17</order></author><author><firstname>Maura</firstname><surname>Matthews</surname><order>18</order></author><author><firstname>Stephanie</firstname><surname>Smits</surname><order>19</order></author><author><firstname>Fiona</firstname><surname>Wood</surname><order>20</order></author><author><firstname>Richard D.</firstname><surname>Neal</surname><order>21</order></author><author><firstname>Kate</firstname><surname>Brain</surname><order>22</order></author><author><firstname>Mari</firstname><surname>Jones</surname><orcid>0000-0001-9661-4899</orcid><order>23</order></author><author><firstname>Angela</firstname><surname>Farr</surname><orcid>0000-0002-2087-9310</orcid><order>24</order></author><author><firstname>(ABACus study</firstname><surname>team)</surname><order>25</order></author></authors><documents><document><filename>57888__21050__b9f6df0776fe4abe848a54a76295e95e.pdf</filename><originalFilename>57888.pdf</originalFilename><uploaded>2021-09-29T12:00:34.4317792</uploaded><type>Output</type><contentLength>703993</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© The Author(s) 2021. 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spelling v2 57888 2021-09-14 Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK f6a4af2cfa4275d2a8ebba292fa14421 0000-0001-5471-922X Berni Sewell Berni Sewell true false 8e326860810f5f960b088db10ef58906 0000-0001-9661-4899 Mari Jones Mari Jones true false ab00dbaa888f32b41b07ef223d0e2987 0000-0002-2087-9310 Angela Farr Angela Farr true false 2021-09-14 PHAC BackgroundCancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation.MethodsThis is a randomised controlled trial involving adults aged 40+ years recruited in community and healthcare settings in deprived areas of South Yorkshire and South-East Wales. Intervention: personalised behavioural advice facilitated by a trained lay advisor. Control: usual care. Follow-up at two weeks and six months post-randomisation. Primary outcome: total cancer symptom recognition score two weeks post-randomisation.ResultsTwo hundred and thirty-four participants were randomised. The difference in total symptom recognition at two weeks [adjusted mean difference (AMD) 0.6, 95% CI: −0.03, 1.17, p = 0.06] was not statistically significant. Intervention participants reported increased symptom recognition (AMD 0.8, 95% CI: 0.18, 1.37, p = 0.01) and earlier intended presentation (AMD −2.0, 95% CI: −3.02, −0.91, p < 0.001) at six months. “Lesser known” symptom recognition was higher in the intervention arm (2 weeks AMD 0.5, 95% CI: 0.03, 0.97 and six months AMD 0.7, 95% CI: 0.16, 1.17). Implementation cost per participant was £91.34, with no significant between-group differences in healthcare resource use post-intervention.ConclusionsImproved symptom recognition and earlier anticipated presentation occurred at longer-term follow-up. The ABACus Health Check is a viable low-cost intervention to increase cancer awareness in socioeconomically deprived communities. Journal Article British Journal of Cancer 125 8 1100 1110 Springer Science and Business Media LLC 0007-0920 1532-1827 12 10 2021 2021-10-12 10.1038/s41416-021-01524-5 COLLEGE NANME Public Health COLLEGE CODE PHAC Swansea University This work was supported by Yorkshire Cancer Research grant number C402. This research comes under the auspices of the Health and Care Research Wales funded by Primary and Emergency Care Research Centre (PRIME) [517195] and Wales Cancer Research Centre [517190]. The Centre for Trials Research (CTR) is funded through the Welsh Government by Health and Care Research Wales and Cancer Research UK. 2023-09-13T16:43:38.2921043 2021-09-14T14:03:55.6933942 Faculty of Medicine, Health and Life Sciences Yvonne Moriarty 1 Mandy Lau 2 Berni Sewell 0000-0001-5471-922X 3 Rob Trubey 4 Harriet Quinn-Scoggins 5 Sioned Owen 6 Louise Padgett 7 Vasiliki Kolovou 8 Julie Hepburn 9 Peter Buckle 10 Rebecca Playle 11 Julia Townson 12 Michael Robling 13 Stephanie Gilbert 14 Polyxeni Dimitropoulou 15 Adrian Edwards 16 Caroline Mitchell 17 Maura Matthews 18 Stephanie Smits 19 Fiona Wood 20 Richard D. Neal 21 Kate Brain 22 Mari Jones 0000-0001-9661-4899 23 Angela Farr 0000-0002-2087-9310 24 (ABACus study team) 25 57888__21050__b9f6df0776fe4abe848a54a76295e95e.pdf 57888.pdf 2021-09-29T12:00:34.4317792 Output 703993 application/pdf Version of Record true © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
spellingShingle Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
Berni Sewell
Mari Jones
Angela Farr
title_short Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
title_full Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
title_fullStr Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
title_full_unstemmed Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
title_sort Randomised controlled trial and economic evaluation of a targeted cancer awareness intervention for adults living in deprived areas of the UK
author_id_str_mv f6a4af2cfa4275d2a8ebba292fa14421
8e326860810f5f960b088db10ef58906
ab00dbaa888f32b41b07ef223d0e2987
author_id_fullname_str_mv f6a4af2cfa4275d2a8ebba292fa14421_***_Berni Sewell
8e326860810f5f960b088db10ef58906_***_Mari Jones
ab00dbaa888f32b41b07ef223d0e2987_***_Angela Farr
author Berni Sewell
Mari Jones
Angela Farr
author2 Yvonne Moriarty
Mandy Lau
Berni Sewell
Rob Trubey
Harriet Quinn-Scoggins
Sioned Owen
Louise Padgett
Vasiliki Kolovou
Julie Hepburn
Peter Buckle
Rebecca Playle
Julia Townson
Michael Robling
Stephanie Gilbert
Polyxeni Dimitropoulou
Adrian Edwards
Caroline Mitchell
Maura Matthews
Stephanie Smits
Fiona Wood
Richard D. Neal
Kate Brain
Mari Jones
Angela Farr
(ABACus study team)
format Journal article
container_title British Journal of Cancer
container_volume 125
container_issue 8
container_start_page 1100
publishDate 2021
institution Swansea University
issn 0007-0920
1532-1827
doi_str_mv 10.1038/s41416-021-01524-5
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
document_store_str 1
active_str 0
description BackgroundCancer outcomes are poor in socioeconomically deprived communities, with low symptom awareness contributing to prolonged help-seeking and advanced disease. Targeted cancer awareness interventions require evaluation.MethodsThis is a randomised controlled trial involving adults aged 40+ years recruited in community and healthcare settings in deprived areas of South Yorkshire and South-East Wales. Intervention: personalised behavioural advice facilitated by a trained lay advisor. Control: usual care. Follow-up at two weeks and six months post-randomisation. Primary outcome: total cancer symptom recognition score two weeks post-randomisation.ResultsTwo hundred and thirty-four participants were randomised. The difference in total symptom recognition at two weeks [adjusted mean difference (AMD) 0.6, 95% CI: −0.03, 1.17, p = 0.06] was not statistically significant. Intervention participants reported increased symptom recognition (AMD 0.8, 95% CI: 0.18, 1.37, p = 0.01) and earlier intended presentation (AMD −2.0, 95% CI: −3.02, −0.91, p < 0.001) at six months. “Lesser known” symptom recognition was higher in the intervention arm (2 weeks AMD 0.5, 95% CI: 0.03, 0.97 and six months AMD 0.7, 95% CI: 0.16, 1.17). Implementation cost per participant was £91.34, with no significant between-group differences in healthcare resource use post-intervention.ConclusionsImproved symptom recognition and earlier anticipated presentation occurred at longer-term follow-up. The ABACus Health Check is a viable low-cost intervention to increase cancer awareness in socioeconomically deprived communities.
published_date 2021-10-12T16:43:40Z
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