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Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study

Matthew Jones, Matthew Jones, Fiona Bell, Jonathan Benger, Sarah Black, Penny Buykx, Simon Dixon, Timothy Driscoll Orcid Logo, Bridie Evans Orcid Logo, Adrian Edwards, Gordon Fuller, Steve Goodacre, Rebecca Hoskins, Jane Hughes, Ann John Orcid Logo, Jenna Jones, Chris Moore, Fiona Sampson, Alan Watkins Orcid Logo, Helen Snooks Orcid Logo

Pilot and Feasibility Studies, Volume: 6, Issue: 1

Swansea University Authors: Matthew Jones, Matthew Jones, Timothy Driscoll Orcid Logo, Bridie Evans Orcid Logo, Ann John Orcid Logo, Jenna Jones, Chris Moore, Alan Watkins Orcid Logo, Helen Snooks Orcid Logo

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DOI (Published version): 10.1186/s40814-020-00626-w

Abstract

BackgroundOpioids, such as heroin, kill more people worldwide by overdose than any other type of drug, and death rates associated with opioid poisoning in the UK are at record levels (World Drug Report 2018 [Internet]. [cited 2019 Nov 19]. Available from: http://www.unodc.org/wdr2018/; Deaths relate...

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Published in: Pilot and Feasibility Studies
ISSN: 2055-5784
Published: Springer Science and Business Media LLC 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa57664
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[cited 2019 Nov 19]. Available from: http://www.unodc.org/wdr2018/; Deaths related to drug poisoning in England and Wales - Office for National Statistics [Internet]. [cited 2019 Nov 19]. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsrelatedtodrugpoisoninginenglandandwales/2018registrations). Naloxone is an opioid antagonist which can be distributed in &#x2018;kits&#x2019; for administration by witnesses in an overdose emergency. This intervention is known as take-home naloxone (THN). We know that THN can save lives on an individual level, but there is currently limited evidence about the effectiveness of THN distribution on an aggregate level, in specialist drug service settings or in emergency service settings. Notably, we do not know whether THN kits reduce deaths from opioid overdose in at-risk populations, if there are unforeseen harms associated with THN distribution or if THN is cost-effective. 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spelling 2021-09-20T16:02:09.6826398 v2 57664 2021-08-19 Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study e3595273bb063f8694ce43326f4bd298 Matthew Jones Matthew Jones true false d063b18627093a02f325955f76eeeb76 Matthew Jones Matthew Jones true false 2be5c329c44d14550ceac4934fcb409e 0000-0001-9879-2509 Timothy Driscoll Timothy Driscoll true false 6098eddc58e31ac2f3e070cb839faa6a 0000-0003-0293-0888 Bridie Evans Bridie Evans true false ed8a9c37bd7b7235b762d941ef18ee55 0000-0002-5657-6995 Ann John Ann John true false e662b6c5aba239a9cd0f115d16df0a82 Jenna Jones Jenna Jones true false f1321a88018c30e9c494421f899ac0cd Chris Moore Chris Moore true false 81fc05c9333d9df41b041157437bcc2f 0000-0003-3804-1943 Alan Watkins Alan Watkins true false ab23c5e0111b88427a155a1f495861d9 0000-0003-0173-8843 Helen Snooks Helen Snooks true false 2021-08-19 PSYS BackgroundOpioids, such as heroin, kill more people worldwide by overdose than any other type of drug, and death rates associated with opioid poisoning in the UK are at record levels (World Drug Report 2018 [Internet]. [cited 2019 Nov 19]. Available from: http://www.unodc.org/wdr2018/; Deaths related to drug poisoning in England and Wales - Office for National Statistics [Internet]. [cited 2019 Nov 19]. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsrelatedtodrugpoisoninginenglandandwales/2018registrations). Naloxone is an opioid antagonist which can be distributed in ‘kits’ for administration by witnesses in an overdose emergency. This intervention is known as take-home naloxone (THN). We know that THN can save lives on an individual level, but there is currently limited evidence about the effectiveness of THN distribution on an aggregate level, in specialist drug service settings or in emergency service settings. Notably, we do not know whether THN kits reduce deaths from opioid overdose in at-risk populations, if there are unforeseen harms associated with THN distribution or if THN is cost-effective. In order to address this research gap, we aim to determine the feasibility of a fully powered cluster randomised controlled trial (RCT) of THN distribution in emergency settings. Journal Article Pilot and Feasibility Studies 6 1 Springer Science and Business Media LLC 2055-5784 9 7 2020 2020-07-09 10.1186/s40814-020-00626-w COLLEGE NANME Psychology School COLLEGE CODE PSYS Swansea University NIHR (National Institute for Health Research) HTA (Health Technology Assessment) programme (reference 15/91/04) 2021-09-20T16:02:09.6826398 2021-08-19T16:36:42.5717865 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Matthew Jones 1 Matthew Jones 2 Fiona Bell 3 Jonathan Benger 4 Sarah Black 5 Penny Buykx 6 Simon Dixon 7 Timothy Driscoll 0000-0001-9879-2509 8 Bridie Evans 0000-0003-0293-0888 9 Adrian Edwards 10 Gordon Fuller 11 Steve Goodacre 12 Rebecca Hoskins 13 Jane Hughes 14 Ann John 0000-0002-5657-6995 15 Jenna Jones 16 Chris Moore 17 Fiona Sampson 18 Alan Watkins 0000-0003-3804-1943 19 Helen Snooks 0000-0003-0173-8843 20 57664__20908__1d525a087f59454090c025c7acf11288.pdf 57664.pdf 2021-09-17T16:23:24.2657500 Output 898445 application/pdf Version of Record true © The Author(s). 2020 This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study
spellingShingle Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study
Matthew Jones
Matthew Jones
Timothy Driscoll
Bridie Evans
Ann John
Jenna Jones
Chris Moore
Alan Watkins
Helen Snooks
title_short Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study
title_full Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study
title_fullStr Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study
title_full_unstemmed Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study
title_sort Protocol for Take-home naloxone In Multicentre Emergency (TIME) settings: feasibility study
author_id_str_mv e3595273bb063f8694ce43326f4bd298
d063b18627093a02f325955f76eeeb76
2be5c329c44d14550ceac4934fcb409e
6098eddc58e31ac2f3e070cb839faa6a
ed8a9c37bd7b7235b762d941ef18ee55
e662b6c5aba239a9cd0f115d16df0a82
f1321a88018c30e9c494421f899ac0cd
81fc05c9333d9df41b041157437bcc2f
ab23c5e0111b88427a155a1f495861d9
author_id_fullname_str_mv e3595273bb063f8694ce43326f4bd298_***_Matthew Jones
d063b18627093a02f325955f76eeeb76_***_Matthew Jones
2be5c329c44d14550ceac4934fcb409e_***_Timothy Driscoll
6098eddc58e31ac2f3e070cb839faa6a_***_Bridie Evans
ed8a9c37bd7b7235b762d941ef18ee55_***_Ann John
e662b6c5aba239a9cd0f115d16df0a82_***_Jenna Jones
f1321a88018c30e9c494421f899ac0cd_***_Chris Moore
81fc05c9333d9df41b041157437bcc2f_***_Alan Watkins
ab23c5e0111b88427a155a1f495861d9_***_Helen Snooks
author Matthew Jones
Matthew Jones
Timothy Driscoll
Bridie Evans
Ann John
Jenna Jones
Chris Moore
Alan Watkins
Helen Snooks
author2 Matthew Jones
Matthew Jones
Fiona Bell
Jonathan Benger
Sarah Black
Penny Buykx
Simon Dixon
Timothy Driscoll
Bridie Evans
Adrian Edwards
Gordon Fuller
Steve Goodacre
Rebecca Hoskins
Jane Hughes
Ann John
Jenna Jones
Chris Moore
Fiona Sampson
Alan Watkins
Helen Snooks
format Journal article
container_title Pilot and Feasibility Studies
container_volume 6
container_issue 1
publishDate 2020
institution Swansea University
issn 2055-5784
doi_str_mv 10.1186/s40814-020-00626-w
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description BackgroundOpioids, such as heroin, kill more people worldwide by overdose than any other type of drug, and death rates associated with opioid poisoning in the UK are at record levels (World Drug Report 2018 [Internet]. [cited 2019 Nov 19]. Available from: http://www.unodc.org/wdr2018/; Deaths related to drug poisoning in England and Wales - Office for National Statistics [Internet]. [cited 2019 Nov 19]. Available from: https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsrelatedtodrugpoisoninginenglandandwales/2018registrations). Naloxone is an opioid antagonist which can be distributed in ‘kits’ for administration by witnesses in an overdose emergency. This intervention is known as take-home naloxone (THN). We know that THN can save lives on an individual level, but there is currently limited evidence about the effectiveness of THN distribution on an aggregate level, in specialist drug service settings or in emergency service settings. Notably, we do not know whether THN kits reduce deaths from opioid overdose in at-risk populations, if there are unforeseen harms associated with THN distribution or if THN is cost-effective. In order to address this research gap, we aim to determine the feasibility of a fully powered cluster randomised controlled trial (RCT) of THN distribution in emergency settings.
published_date 2020-07-09T14:07:41Z
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