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Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution

Anoshanth Jeyasountharan, Keshvad Shahrivar, Gaetano D’Avino, Francesco Del Giudice Orcid Logo

Analytical Chemistry, Volume: 93, Issue: 13, Pages: 5503 - 5512

Swansea University Author: Francesco Del Giudice Orcid Logo

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DOI (Published version): 10.1021/acs.analchem.0c05370

Abstract

Viscoelastic polymer solutions have been widely employed as suspending liquids for a myriad of microfluidic applications including particle and cell focusing, sorting, and encapsulation. It has been recently shown that viscoelastic solutions can drive the formation of equally spaced particles called...

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Published in: Analytical Chemistry
ISSN: 0003-2700 1520-6882
Published: American Chemical Society (ACS) 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa56355
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spelling 2022-03-04T14:10:37.9514996 v2 56355 2021-03-02 Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2021-03-02 CHEG Viscoelastic polymer solutions have been widely employed as suspending liquids for a myriad of microfluidic applications including particle and cell focusing, sorting, and encapsulation. It has been recently shown that viscoelastic solutions can drive the formation of equally spaced particles called "particle trains"as a result of the viscoelasticity-mediated hydrodynamic interactions between adjacent particles. Despite their potential impact on applications such as droplet encapsulation and flow cytometry, only limited experimental studies on viscoelastic ordering are currently available. In this work, we demonstrate that a viscoelastic shear-thinning aqueous xanthan gum solution drives the self-assembly of particle trains on the centerline of a serpentine microfluidic device with a nearly circular cross section. After focusing, the flowing particles change their mutual distance and organize in aligned structures characterized by a preferential spacing, quantified in terms of distributions of the interparticle distance. We observe the occurrence of multi-particle strings, mainly doublets and triplets, that interrupt the continuity of the particle train. To account for the fluctuations in the number of flowing particles in the experimental window, we introduce the concept of local particle concentration, observing that an increase of the local particle concentration leads to an increase of doublets and triplets. We also demonstrate that using only a single tube to connect the sample to the microfluidic device results in a drastic reduction of doublets/triplets, thus leading to a more uniform particle train. Our findings establish the foundation for optimized applications such as deterministic droplet encapsulation in viscoelastic liquids and optimized flow cytometry. Journal Article Analytical Chemistry 93 13 5503 5512 American Chemical Society (ACS) 0003-2700 1520-6882 6 4 2021 2021-04-06 10.1021/acs.analchem.0c05370 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University External research funder(s) paid the OA fee (includes OA grants disbursed by the Library) UKRI, EP/S036490/1 2022-03-04T14:10:37.9514996 2021-03-02T10:53:33.7789404 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Anoshanth Jeyasountharan 1 Keshvad Shahrivar 2 Gaetano D’Avino 3 Francesco Del Giudice 0000-0002-9414-6937 4 56355__19871__12b70adf7c594553b5fb70ec0edd7b5d.pdf 56355.pdf 2021-05-13T10:16:24.2186442 Output 2174075 application/pdf Version of Record true true eng http://creativecommons.org/licenses/by/4.0/
title Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution
spellingShingle Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution
Francesco Del Giudice
title_short Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution
title_full Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution
title_fullStr Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution
title_full_unstemmed Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution
title_sort Viscoelastic Particle Train Formation in Microfluidic Flows Using a Xanthan Gum Aqueous Solution
author_id_str_mv 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv 742d483071479b44d7888e16166b1309_***_Francesco Del Giudice
author Francesco Del Giudice
author2 Anoshanth Jeyasountharan
Keshvad Shahrivar
Gaetano D’Avino
Francesco Del Giudice
format Journal article
container_title Analytical Chemistry
container_volume 93
container_issue 13
container_start_page 5503
publishDate 2021
institution Swansea University
issn 0003-2700
1520-6882
doi_str_mv 10.1021/acs.analchem.0c05370
publisher American Chemical Society (ACS)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
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description Viscoelastic polymer solutions have been widely employed as suspending liquids for a myriad of microfluidic applications including particle and cell focusing, sorting, and encapsulation. It has been recently shown that viscoelastic solutions can drive the formation of equally spaced particles called "particle trains"as a result of the viscoelasticity-mediated hydrodynamic interactions between adjacent particles. Despite their potential impact on applications such as droplet encapsulation and flow cytometry, only limited experimental studies on viscoelastic ordering are currently available. In this work, we demonstrate that a viscoelastic shear-thinning aqueous xanthan gum solution drives the self-assembly of particle trains on the centerline of a serpentine microfluidic device with a nearly circular cross section. After focusing, the flowing particles change their mutual distance and organize in aligned structures characterized by a preferential spacing, quantified in terms of distributions of the interparticle distance. We observe the occurrence of multi-particle strings, mainly doublets and triplets, that interrupt the continuity of the particle train. To account for the fluctuations in the number of flowing particles in the experimental window, we introduce the concept of local particle concentration, observing that an increase of the local particle concentration leads to an increase of doublets and triplets. We also demonstrate that using only a single tube to connect the sample to the microfluidic device results in a drastic reduction of doublets/triplets, thus leading to a more uniform particle train. Our findings establish the foundation for optimized applications such as deterministic droplet encapsulation in viscoelastic liquids and optimized flow cytometry.
published_date 2021-04-06T04:11:15Z
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