In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate

Tan, Wee Kiat; Yi, Alyssa Rui; Sivanandam, Punitha; Hui, Ernest Jing; Yap, Ze Ping; Saburulla, Nur Fazilah; Austin-Muttitt, Karl; Mullins, Jonathan; Lau, Aik Jiang

doi:10.1124/jpet.120.265249

Journal article 1355 views

In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon...

Wee Kiat Tan, Alyssa Rui Yi Tan, Punitha Sivanandam, Ernest Jing Hui Goh, Ze Ping Yap, Nur Fazilah Saburulla, Karl Austin-Muttitt, Jonathan Mullins

, Aik Jiang Lau

Journal of Pharmacology and Experimental Therapeutics, Volume: 374, Issue: 2, Pages: 295 - 307

Swansea University Authors: Karl Austin-Muttitt, Jonathan Mullins

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1124/jpet.120.265249

Published in:	Journal of Pharmacology and Experimental Therapeutics
ISSN:	0022-3565 1521-0103
Published:	American Society for Pharmacology & Experimental Therapeutics (ASPET) 2020
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa55640

first_indexed	2020-12-29T16:47:12Z
last_indexed	2020-12-30T04:18:42Z
id	cronfa55640
recordtype	SURis
fullrecord	<?xml version="1.0"?><rfc1807><datestamp>2020-12-29T16:47:32.5914983</datestamp><bib-version>v2</bib-version><id>55640</id><entry>2020-11-10</entry><title>In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate</title><swanseaauthors><author><sid>fafc0917b48af4eaec154646854867f8</sid><firstname>Karl</firstname><surname>Austin-Muttitt</surname><name>Karl Austin-Muttitt</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>4cf2dddedbe1dacb506ec925fdbd5b40</sid><ORCID>0000-0003-0144-2962</ORCID><firstname>Jonathan</firstname><surname>Mullins</surname><name>Jonathan Mullins</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2020-11-10</date><deptcode>MEDS</deptcode><abstract/><type>Journal Article</type><journal>Journal of Pharmacology and Experimental Therapeutics</journal><volume>374</volume><journalNumber>2</journalNumber><paginationStart>295</paginationStart><paginationEnd>307</paginationEnd><publisher>American Society for Pharmacology & Experimental Therapeutics (ASPET)</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0022-3565</issnPrint><issnElectronic>1521-0103</issnElectronic><keywords/><publishedDay>1</publishedDay><publishedMonth>8</publishedMonth><publishedYear>2020</publishedYear><publishedDate>2020-08-01</publishedDate><doi>10.1124/jpet.120.265249</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-12-29T16:47:32.5914983</lastEdited><Created>2020-11-10T13:23:41.1831301</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Wee Kiat</firstname><surname>Tan</surname><order>1</order></author><author><firstname>Alyssa Rui Yi</firstname><surname>Tan</surname><order>2</order></author><author><firstname>Punitha</firstname><surname>Sivanandam</surname><order>3</order></author><author><firstname>Ernest Jing Hui</firstname><surname>Goh</surname><order>4</order></author><author><firstname>Ze Ping</firstname><surname>Yap</surname><order>5</order></author><author><firstname>Nur Fazilah</firstname><surname>Saburulla</surname><order>6</order></author><author><firstname>Karl</firstname><surname>Austin-Muttitt</surname><order>7</order></author><author><firstname>Jonathan</firstname><surname>Mullins</surname><orcid>0000-0003-0144-2962</orcid><order>8</order></author><author><firstname>Aik Jiang</firstname><surname>Lau</surname><order>9</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling	2020-12-29T16:47:32.5914983 v2 55640 2020-11-10 In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate fafc0917b48af4eaec154646854867f8 Karl Austin-Muttitt Karl Austin-Muttitt true false 4cf2dddedbe1dacb506ec925fdbd5b40 0000-0003-0144-2962 Jonathan Mullins Jonathan Mullins true false 2020-11-10 MEDS Journal Article Journal of Pharmacology and Experimental Therapeutics 374 2 295 307 American Society for Pharmacology & Experimental Therapeutics (ASPET) 0022-3565 1521-0103 1 8 2020 2020-08-01 10.1124/jpet.120.265249 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2020-12-29T16:47:32.5914983 2020-11-10T13:23:41.1831301 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Wee Kiat Tan 1 Alyssa Rui Yi Tan 2 Punitha Sivanandam 3 Ernest Jing Hui Goh 4 Ze Ping Yap 5 Nur Fazilah Saburulla 6 Karl Austin-Muttitt 7 Jonathan Mullins 0000-0003-0144-2962 8 Aik Jiang Lau 9
title	In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate
spellingShingle	In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate Karl Austin-Muttitt Jonathan Mullins
title_short	In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate
title_full	In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate
title_fullStr	In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate
title_full_unstemmed	In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate
title_sort	In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon and Methotrexate
author_id_str_mv	fafc0917b48af4eaec154646854867f8 4cf2dddedbe1dacb506ec925fdbd5b40
author_id_fullname_str_mv	fafc0917b48af4eaec154646854867f8_*_Karl Austin-Muttitt 4cf2dddedbe1dacb506ec925fdbd5b40_*_Jonathan Mullins
author	Karl Austin-Muttitt Jonathan Mullins
author2	Wee Kiat Tan Alyssa Rui Yi Tan Punitha Sivanandam Ernest Jing Hui Goh Ze Ping Yap Nur Fazilah Saburulla Karl Austin-Muttitt Jonathan Mullins Aik Jiang Lau
format	Journal article
container_title	Journal of Pharmacology and Experimental Therapeutics
container_volume	374
container_issue	2
container_start_page	295
publishDate	2020
institution	Swansea University
issn	0022-3565 1521-0103
doi_str_mv	10.1124/jpet.120.265249
publisher	American Society for Pharmacology & Experimental Therapeutics (ASPET)
college_str	Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str	0
active_str	0
published_date	2020-08-01T04:51:44Z
_version_	1851095571835650048
score	11.089407

In Vitro Inhibition of Human Aldehyde Oxidase Activity by Clinically Relevant Concentrations of Gefitinib and Erlotinib: Comparison with Select Metabolites, Molecular Docking Analysis, and Impact on Hepatic Metabolism of Zaleplon...

Similar Items