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The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis

Ruth Davies, Jessica Williams, Katie Sime, Hyun-Sun Jin, Charlotte Thompson, Lauren Jordan, Derek Lang, Julian P Halcox, Elizabeth Ellins, Gareth W Jones, Simon A Jones, Stefan Rose-John, Anwen Williams, Ernest Choy, Julian Halcox, Libby Ellins Orcid Logo

Rheumatology, Volume: 60, Issue: 6, Pages: 2852 - 2861

Swansea University Authors: Julian Halcox, Libby Ellins Orcid Logo

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DOI (Published version): 10.1093/rheumatology/keaa725

Abstract

Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the...

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Published in: Rheumatology
ISSN: 1462-0324 1462-0332
Published: Oxford University Press (OUP) 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa55470
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first_indexed 2020-11-03T10:27:30Z
last_indexed 2021-09-18T03:17:33Z
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spelling 2021-09-17T14:42:48.5864685 v2 55470 2020-10-21 The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis 5e543256c480ac577d30f76f9120eb74 Julian Halcox Julian Halcox true false 553ce2abe05a6396e7dd6eadb6b90a6d 0000-0001-5164-6416 Libby Ellins Libby Ellins true false 2020-10-21 Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the two modes of IL-6 signalling, trans-signalling is pro-inflammatory whereas classical signalling is linked with inflammation resolution. This study examines the role of IL-6 trans-signalling in CVD in a mouse model and patients with RA. Journal Article Rheumatology 60 6 2852 2861 Oxford University Press (OUP) 1462-0324 1462-0332 RA, inflammation, cardiovascular diseases, experimental arthritis 18 6 2021 2021-06-18 10.1093/rheumatology/keaa725 COLLEGE NANME COLLEGE CODE Swansea University 2021-09-17T14:42:48.5864685 2020-10-21T09:23:50.1428347 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Ruth Davies 1 Jessica Williams 2 Katie Sime 3 Hyun-Sun Jin 4 Charlotte Thompson 5 Lauren Jordan 6 Derek Lang 7 Julian P Halcox 8 Elizabeth Ellins 9 Gareth W Jones 10 Simon A Jones 11 Stefan Rose-John 12 Anwen Williams 13 Ernest Choy 14 Julian Halcox 15 Libby Ellins 0000-0001-5164-6416 16 55470__18884__136fa8039b84446e96a854bf60258f35.pdf 55470.pdf 2020-12-14T18:07:20.0407375 Output 471147 application/pdf Version of Record true ©The Author(s) 2020. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License true eng http://creativecommons.org/licenses/by-nc/4.0/
title The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
spellingShingle The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
Julian Halcox
Libby Ellins
title_short The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
title_full The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
title_fullStr The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
title_full_unstemmed The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
title_sort The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
author_id_str_mv 5e543256c480ac577d30f76f9120eb74
553ce2abe05a6396e7dd6eadb6b90a6d
author_id_fullname_str_mv 5e543256c480ac577d30f76f9120eb74_***_Julian Halcox
553ce2abe05a6396e7dd6eadb6b90a6d_***_Libby Ellins
author Julian Halcox
Libby Ellins
author2 Ruth Davies
Jessica Williams
Katie Sime
Hyun-Sun Jin
Charlotte Thompson
Lauren Jordan
Derek Lang
Julian P Halcox
Elizabeth Ellins
Gareth W Jones
Simon A Jones
Stefan Rose-John
Anwen Williams
Ernest Choy
Julian Halcox
Libby Ellins
format Journal article
container_title Rheumatology
container_volume 60
container_issue 6
container_start_page 2852
publishDate 2021
institution Swansea University
issn 1462-0324
1462-0332
doi_str_mv 10.1093/rheumatology/keaa725
publisher Oxford University Press (OUP)
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Cardiovascular (CV) mortality in RA patients is 50% higher than in the general population. There is increasing recognition that systemic inflammation is a major driver of this. IL-6 is implicated in cardiovascular disease (CVD) in the general population but its role in CVD in RA is undefined. Of the two modes of IL-6 signalling, trans-signalling is pro-inflammatory whereas classical signalling is linked with inflammation resolution. This study examines the role of IL-6 trans-signalling in CVD in a mouse model and patients with RA.
published_date 2021-06-18T04:09:42Z
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score 11.013148

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