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Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury

Stephen Evans Orcid Logo, Aled Roberts, Andrew Conway Morris, A. John Simpson, Llinos Harris Orcid Logo, Dietrich Mack, Rowena Jenkins Orcid Logo, Thomas Wilkinson Orcid Logo

Scientific Reports, Volume: 10, Issue: 1

Swansea University Authors: Stephen Evans Orcid Logo, Aled Roberts, Llinos Harris Orcid Logo, Rowena Jenkins Orcid Logo, Thomas Wilkinson Orcid Logo

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DOI (Published version): 10.1038/s41598-020-72454-0

Abstract

Background: To manage increasing demand for emergency and unscheduled care NHS England policy haspromoted services in which patients presenting to Emergency Departments (EDs) with non-urgent problems aredirected to general practitioners (GPs) and other primary care clinicians working within or along...

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Published in: Scientific Reports
ISSN: 2045-2322
Published: Springer Science and Business Media LLC 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa55318
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However, the ways that hospitals have implemented primary care services in EDs are varied. The aimof this study was to describe ED clinical leads&#x2019; experiences of implementing and delivering &#x2018;primary care services&#x2019;and &#x2018;emergency medicine services&#x2019; where GPs were integrated into the ED team. Methods: We conducted interviews with ED clinical leads in England (n = 19) and Wales (n = 2). We usedframework analysis to analyse interview transcripts and explore differences across &#x2018;primary care services&#x2019;, &#x2018;emergency medicine services&#x2019; and emergency departments without primary care services. Results: In EDs with separate primary care services, success was reported when having a distinct workforce ofprimary care clinicians, who improved waiting times and flow by seeing primary care-type patients in a timely way,using fewer investigations, and enabling ED doctors to focus on more acutely unwell patients. Some challengeswere: trying to align their service with the policy guidance, inconsistent demand for primary care, accessiblecommunity primary care services, difficulties in recruiting GPs, lack of funding, difficulties in agreeing governanceprotocols and establishing effective streaming pathways. Where GPs were integrated into an ED workforce successwas reported as managing the demand for both emergency and primary care and reducing admissions</abstract><type>Journal Article</type><journal>Scientific Reports</journal><volume>10</volume><journalNumber>1</journalNumber><paginationStart/><paginationEnd/><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint/><issnElectronic>2045-2322</issnElectronic><keywords/><publishedDay>1</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2020</publishedYear><publishedDate>2020-12-01</publishedDate><doi>10.1038/s41598-020-72454-0</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-12-03T16:42:51.3501524</lastEdited><Created>2020-10-05T10:29:31.2500736</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Stephen</firstname><surname>Evans</surname><orcid>0000-0002-5352-9800</orcid><order>1</order></author><author><firstname>Aled</firstname><surname>Roberts</surname><order>2</order></author><author><firstname>Andrew Conway</firstname><surname>Morris</surname><order>3</order></author><author><firstname>A. 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spelling 2020-12-03T16:42:51.3501524 v2 55318 2020-10-05 Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury cfca981bdfb8492873a48cc1629def9a 0000-0002-5352-9800 Stephen Evans Stephen Evans true false 2734a184ebdeb828c9403c77b7938de0 Aled Roberts Aled Roberts true false dc70f9d4badbbdb5d467fd321986d173 0000-0002-0295-3038 Llinos Harris Llinos Harris true false caf58cd775a27bf8b9ee340079a29cc0 0000-0001-6664-6099 Rowena Jenkins Rowena Jenkins true false 86cca6bf31bfe8572de27c1b441420d8 0000-0003-0397-6079 Thomas Wilkinson Thomas Wilkinson true false 2020-10-05 BMS Background: To manage increasing demand for emergency and unscheduled care NHS England policy haspromoted services in which patients presenting to Emergency Departments (EDs) with non-urgent problems aredirected to general practitioners (GPs) and other primary care clinicians working within or alongside emergencydepartments. However, the ways that hospitals have implemented primary care services in EDs are varied. The aimof this study was to describe ED clinical leads’ experiences of implementing and delivering ‘primary care services’and ‘emergency medicine services’ where GPs were integrated into the ED team. Methods: We conducted interviews with ED clinical leads in England (n = 19) and Wales (n = 2). We usedframework analysis to analyse interview transcripts and explore differences across ‘primary care services’, ‘emergency medicine services’ and emergency departments without primary care services. Results: In EDs with separate primary care services, success was reported when having a distinct workforce ofprimary care clinicians, who improved waiting times and flow by seeing primary care-type patients in a timely way,using fewer investigations, and enabling ED doctors to focus on more acutely unwell patients. Some challengeswere: trying to align their service with the policy guidance, inconsistent demand for primary care, accessiblecommunity primary care services, difficulties in recruiting GPs, lack of funding, difficulties in agreeing governanceprotocols and establishing effective streaming pathways. Where GPs were integrated into an ED workforce successwas reported as managing the demand for both emergency and primary care and reducing admissions Journal Article Scientific Reports 10 1 Springer Science and Business Media LLC 2045-2322 1 12 2020 2020-12-01 10.1038/s41598-020-72454-0 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2020-12-03T16:42:51.3501524 2020-10-05T10:29:31.2500736 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Stephen Evans 0000-0002-5352-9800 1 Aled Roberts 2 Andrew Conway Morris 3 A. John Simpson 4 Llinos Harris 0000-0002-0295-3038 5 Dietrich Mack 6 Rowena Jenkins 0000-0001-6664-6099 7 Thomas Wilkinson 0000-0003-0397-6079 8 55318__18605__2172725995194b9495b75aaa2c7603f7.pdf 55318.VOR.pdf 2020-11-06T15:18:27.6161093 Output 1459343 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury
spellingShingle Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury
Stephen Evans
Aled Roberts
Llinos Harris
Rowena Jenkins
Thomas Wilkinson
title_short Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury
title_full Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury
title_fullStr Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury
title_full_unstemmed Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury
title_sort Contrasting effects of linezolid on healthy and dysfunctional human neutrophils: reducing C5a-induced injury
author_id_str_mv cfca981bdfb8492873a48cc1629def9a
2734a184ebdeb828c9403c77b7938de0
dc70f9d4badbbdb5d467fd321986d173
caf58cd775a27bf8b9ee340079a29cc0
86cca6bf31bfe8572de27c1b441420d8
author_id_fullname_str_mv cfca981bdfb8492873a48cc1629def9a_***_Stephen Evans
2734a184ebdeb828c9403c77b7938de0_***_Aled Roberts
dc70f9d4badbbdb5d467fd321986d173_***_Llinos Harris
caf58cd775a27bf8b9ee340079a29cc0_***_Rowena Jenkins
86cca6bf31bfe8572de27c1b441420d8_***_Thomas Wilkinson
author Stephen Evans
Aled Roberts
Llinos Harris
Rowena Jenkins
Thomas Wilkinson
author2 Stephen Evans
Aled Roberts
Andrew Conway Morris
A. John Simpson
Llinos Harris
Dietrich Mack
Rowena Jenkins
Thomas Wilkinson
format Journal article
container_title Scientific Reports
container_volume 10
container_issue 1
publishDate 2020
institution Swansea University
issn 2045-2322
doi_str_mv 10.1038/s41598-020-72454-0
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Background: To manage increasing demand for emergency and unscheduled care NHS England policy haspromoted services in which patients presenting to Emergency Departments (EDs) with non-urgent problems aredirected to general practitioners (GPs) and other primary care clinicians working within or alongside emergencydepartments. However, the ways that hospitals have implemented primary care services in EDs are varied. The aimof this study was to describe ED clinical leads’ experiences of implementing and delivering ‘primary care services’and ‘emergency medicine services’ where GPs were integrated into the ED team. Methods: We conducted interviews with ED clinical leads in England (n = 19) and Wales (n = 2). We usedframework analysis to analyse interview transcripts and explore differences across ‘primary care services’, ‘emergency medicine services’ and emergency departments without primary care services. Results: In EDs with separate primary care services, success was reported when having a distinct workforce ofprimary care clinicians, who improved waiting times and flow by seeing primary care-type patients in a timely way,using fewer investigations, and enabling ED doctors to focus on more acutely unwell patients. Some challengeswere: trying to align their service with the policy guidance, inconsistent demand for primary care, accessiblecommunity primary care services, difficulties in recruiting GPs, lack of funding, difficulties in agreeing governanceprotocols and establishing effective streaming pathways. Where GPs were integrated into an ED workforce successwas reported as managing the demand for both emergency and primary care and reducing admissions
published_date 2020-12-01T04:09:26Z
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