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Ozone: A Potential Oxidant for COVID-19 Virus (SARS-CoV-2)

Chedly Tizaoui Orcid Logo

Ozone: Science & Engineering, Volume: 42, Issue: 5, Pages: 378 - 385

Swansea University Author: Chedly Tizaoui Orcid Logo

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DOI (Published version): 10.1080/01919512.2020.1795614

Abstract

Currently, no medicine has demonstrated efficacy in treating the ongoing pandemic COVID-19 caused by SARS-CoV-2 virus. Being a potent oxidant, ozone is lethal against most bacteria and viruses found in water, or on surfaces and aerosols. Ozone has also been successfully used to treat several viral d...

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Published in: Ozone: Science & Engineering
ISSN: 0191-9512 1547-6545
Published: Informa UK Limited 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa54867
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Abstract: Currently, no medicine has demonstrated efficacy in treating the ongoing pandemic COVID-19 caused by SARS-CoV-2 virus. Being a potent oxidant, ozone is lethal against most bacteria and viruses found in water, or on surfaces and aerosols. Ozone has also been successfully used to treat several viral diseases such as Ebola and HIV Hepatitis B and C. Using molecular modeling, this study evaluated the reactivity of ozone toward representative key molecules in the structure of SARS-CoV-2. The results show that ozone is able to attack the proteins and lipids of the virus’s spikes and envelope, particularly the amino acids tryptophan, methionine and cysteine, and the fatty acids, arachidonic acid, linoleic acid, and oleic acid. Ozone also attacks the N-glycopeptides of the spike protein subunits 1 and 2, though at lower reactivity. Disruption of the structure of SARS-CoV-2 could inactivate the virus, suggesting that ozone could be an effective oxidant against COVID-19 virus. If incorrectly applied, ozone is toxic and contact with the respiratory tract must be avoided.
Keywords: Ozone, SARS-CoV-2, COVID-19, coronavirus, severe acute respiratory syndrome
College: Faculty of Science and Engineering
Issue: 5
Start Page: 378
End Page: 385

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