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Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial

O. Nicholas, C. Bowden, A. Selby, Owen Bodger Orcid Logo, Paul Lewis, R. Webster, G. Radhakrishna, G. Jones, M. Hawkins, S. Mukherjee, T. Crosby, S. Gwynne

Clinical Oncology, Volume: 32, Issue: 12

Swansea University Authors: Owen Bodger Orcid Logo, Paul Lewis

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DOI (Published version): 10.1016/j.clon.2020.06.022

Abstract

Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4...

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Published in: Clinical Oncology
ISSN: 0936-6555
Published: Elsevier BV 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa54566
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first_indexed 2020-06-29T17:42:32Z
last_indexed 2021-01-07T04:18:12Z
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spelling v2 54566 2020-06-29 Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial 8096440ab42b60a86e6aba678fe2695a 0000-0002-4022-9964 Owen Bodger Owen Bodger true false 46dfc22d7468f247c390ba0c6cd8fba6 Paul Lewis Paul Lewis true false 2020-06-29 HDAT Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4D-CT into the radiotherapy planning. Using NeoSCOPE 4D-CT cases, we undertook a dosimetric comparison study of 3D-CT versus 4D-CT plans comparing target volume coverage and dose to organs at risk. We used established normal tissue complication probability (NTCP) models to evaluate the potential toxicity reduction of using 4D-CT plans in oesophageal cancer. Our work shows that incorporating 4D-CT into treatment planning may significantly reduce the toxicity burden from this treatment. Journal Article Clinical Oncology 32 12 Elsevier BV 0936-6555 4D-CT planning; NTCP; oesophageal cancer; organs at risk; postoperative toxicity; radiotherapy 19 7 2020 2020-07-19 10.1016/j.clon.2020.06.022 COLLEGE NANME Health Data Science COLLEGE CODE HDAT Swansea University 2024-01-08T10:30:37.7861897 2020-06-29T18:37:41.1319713 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Health Data Science O. Nicholas 1 C. Bowden 2 A. Selby 3 Owen Bodger 0000-0002-4022-9964 4 Paul Lewis 5 R. Webster 6 G. Radhakrishna 7 G. Jones 8 M. Hawkins 9 S. Mukherjee 10 T. Crosby 11 S. Gwynne 12 54566__17929__3847dfc0a0854be2ab37285847a22f85.pdf 54566.pdf 2020-08-16T13:06:58.4235167 Output 256241 application/pdf Accepted Manuscript true 2021-07-19T00:00:00.0000000 Released under the terms of a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND). true eng
title Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial
spellingShingle Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial
Owen Bodger
Paul Lewis
title_short Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial
title_full Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial
title_fullStr Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial
title_full_unstemmed Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial
title_sort Comparative Dosimetric Analysis and Normal Tissue Complication Probability Modelling of Four-Dimensional Computed Tomography Planning Scans Within the UK NeoSCOPE Trial
author_id_str_mv 8096440ab42b60a86e6aba678fe2695a
46dfc22d7468f247c390ba0c6cd8fba6
author_id_fullname_str_mv 8096440ab42b60a86e6aba678fe2695a_***_Owen Bodger
46dfc22d7468f247c390ba0c6cd8fba6_***_Paul Lewis
author Owen Bodger
Paul Lewis
author2 O. Nicholas
C. Bowden
A. Selby
Owen Bodger
Paul Lewis
R. Webster
G. Radhakrishna
G. Jones
M. Hawkins
S. Mukherjee
T. Crosby
S. Gwynne
format Journal article
container_title Clinical Oncology
container_volume 32
container_issue 12
publishDate 2020
institution Swansea University
issn 0936-6555
doi_str_mv 10.1016/j.clon.2020.06.022
publisher Elsevier BV
college_str Faculty of Medicine, Health and Life Sciences
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hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Health Data Science{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Health Data Science
document_store_str 1
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description Neoadjuvant chemoradiotherapy for resectable oesophageal cancer improves overall survival compared to surgery alone but is associated with increased toxicity. NeoSCOPE is a trial of two different nCRT regimens for resectable oesophageal and was the first multi-centre trial in the UK to incorporate 4D-CT into the radiotherapy planning. Using NeoSCOPE 4D-CT cases, we undertook a dosimetric comparison study of 3D-CT versus 4D-CT plans comparing target volume coverage and dose to organs at risk. We used established normal tissue complication probability (NTCP) models to evaluate the potential toxicity reduction of using 4D-CT plans in oesophageal cancer. Our work shows that incorporating 4D-CT into treatment planning may significantly reduce the toxicity burden from this treatment.
published_date 2020-07-19T10:30:39Z
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