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Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial

Shane Heffernan Orcid Logo, C. McCarthy, S. Eustace, R.E. FitzPatrick, E. Delahunt, G. De Vito

Complementary Therapies in Medicine, Volume: 50

Swansea University Author: Shane Heffernan Orcid Logo

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DOI (Published version): 10.1016/j.ctim.2020.102349

Abstract

IntroductionOsteoarthritis (OA) is characterised by synovial joint pain, functional disability and affects ∼13% of people worldwide, of which ∼16-27% report Knee-OA (KOA). Glucosamine (Glu) is the most widely used nutraceutical treatment for OA despite a lack of scientific consensus, therefore alter...

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Published in: Complementary Therapies in Medicine
ISSN: 0965-2299
Published: 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa53601
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Glucosamine (Glu) is the most widely used nutraceutical treatment for OA despite a lack of scientific consensus, therefore alternative nutraceutical treatments are required. The aim of this study was to investigate the effect of Lithothamnion species, seawater-derived magnesium and pine bark (Aq+) on pain, symptoms and improve physical function in symptomatic (sKOA), compared to Glu.Methods358 participants were screened. In a double-blinded crossover pilot-trial, sKOA participant (n&#x2009;=&#x2009;30) were randomly assigned to either the Glu group (2000&#x2009;mg&#x2009;day-1) or Aq+ (3056&#x2009;mg&#x2009;day-1) for 12 weeks (clinicaltrials.gov:NCT03106584). The Knee Injury and Osteoarthritis Outcome Score was used to assess subjective pain and symptoms. Timed-up-and-Go (TuG) and Six minute walking distance were used to assess functional change and analgesic use was recorded.ResultsAq+ improved pain, with a large effect (P&#x2009;&lt;&#x2009;0.01, d&#x2019;&#x2009;=&#x2009;0.73, 95%CI 0.201-1.265) and no change for Glu (d&#x2019;&#x2009;=&#x2009;0.38, P&#x2009;=&#x2009;0.06). Only Aq+ improved pain (P&#x2009;&lt;&#x2009;0.05) for males (d&#x2019;&#x2009;=&#x2009;0.91, 95%CI 0.162-1.667) and females (d&#x2019;&#x2009;=&#x2009;0.55, 95%CI 0.210-1.299). In females, Aq+ improved TuG by -7.02% (d&#x2019;&#x2009;=&#x2009;0.92, 95%CI 1.699-0.141) while Glu worsened performance by 4.18% (P&#x2009;=&#x2009;0.04). Aq+ reduced analgesia by 71.6%, compared to Glu (P&#x2009;=&#x2009;0.02; d&#x2019;&#x2009;=&#x2009;0.82, 95%CI 1.524-0.123). Aq+ was superior to Glu at improving pain, KOOS subscales, physical function and analgesia use in mild-sKOA. 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spelling 2021-01-14T13:51:53.4409327 v2 53601 2020-02-21 Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false 2020-02-21 STSC IntroductionOsteoarthritis (OA) is characterised by synovial joint pain, functional disability and affects ∼13% of people worldwide, of which ∼16-27% report Knee-OA (KOA). Glucosamine (Glu) is the most widely used nutraceutical treatment for OA despite a lack of scientific consensus, therefore alternative nutraceutical treatments are required. The aim of this study was to investigate the effect of Lithothamnion species, seawater-derived magnesium and pine bark (Aq+) on pain, symptoms and improve physical function in symptomatic (sKOA), compared to Glu.Methods358 participants were screened. In a double-blinded crossover pilot-trial, sKOA participant (n = 30) were randomly assigned to either the Glu group (2000 mg day-1) or Aq+ (3056 mg day-1) for 12 weeks (clinicaltrials.gov:NCT03106584). The Knee Injury and Osteoarthritis Outcome Score was used to assess subjective pain and symptoms. Timed-up-and-Go (TuG) and Six minute walking distance were used to assess functional change and analgesic use was recorded.ResultsAq+ improved pain, with a large effect (P < 0.01, d’ = 0.73, 95%CI 0.201-1.265) and no change for Glu (d’ = 0.38, P = 0.06). Only Aq+ improved pain (P < 0.05) for males (d’ = 0.91, 95%CI 0.162-1.667) and females (d’ = 0.55, 95%CI 0.210-1.299). In females, Aq+ improved TuG by -7.02% (d’ = 0.92, 95%CI 1.699-0.141) while Glu worsened performance by 4.18% (P = 0.04). Aq+ reduced analgesia by 71.6%, compared to Glu (P = 0.02; d’ = 0.82, 95%CI 1.524-0.123). Aq+ was superior to Glu at improving pain, KOOS subscales, physical function and analgesia use in mild-sKOA. Given these data, Aq+ should be considered as a supplementary treatment for early-stage-KOA and may have the potential to reduce use of pain medication, although larger replication studies are required. Journal Article Complementary Therapies in Medicine 50 0965-2299 Lithothamnion, pain management, nutraceutical, seawater magnesium 1 5 2020 2020-05-01 10.1016/j.ctim.2020.102349 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2021-01-14T13:51:53.4409327 2020-02-21T09:58:34.5468583 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Shane Heffernan 0000-0002-3297-9335 1 C. McCarthy 2 S. Eustace 3 R.E. FitzPatrick 4 E. Delahunt 5 G. De Vito 6 53601__16657__fa6141d61592400196386532fa8488fc.pdf Heffernan2020.pdf 2020-02-21T10:04:49.7566495 Output 2554723 application/pdf Accepted Manuscript true 2021-02-19T00:00:00.0000000 Released under the terms of a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND). true eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial
spellingShingle Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial
Shane Heffernan
title_short Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial
title_full Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial
title_fullStr Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial
title_full_unstemmed Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial
title_sort Mineral rich algae with pine bark improved pain, physical function and analgesic use in mild-knee joint osteoarthritis, compared to Glucosamine: a randomized controlled pilot trial
author_id_str_mv 72c0b36891dfbec0378c0d0f7916e807
author_id_fullname_str_mv 72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan
author Shane Heffernan
author2 Shane Heffernan
C. McCarthy
S. Eustace
R.E. FitzPatrick
E. Delahunt
G. De Vito
format Journal article
container_title Complementary Therapies in Medicine
container_volume 50
publishDate 2020
institution Swansea University
issn 0965-2299
doi_str_mv 10.1016/j.ctim.2020.102349
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
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description IntroductionOsteoarthritis (OA) is characterised by synovial joint pain, functional disability and affects ∼13% of people worldwide, of which ∼16-27% report Knee-OA (KOA). Glucosamine (Glu) is the most widely used nutraceutical treatment for OA despite a lack of scientific consensus, therefore alternative nutraceutical treatments are required. The aim of this study was to investigate the effect of Lithothamnion species, seawater-derived magnesium and pine bark (Aq+) on pain, symptoms and improve physical function in symptomatic (sKOA), compared to Glu.Methods358 participants were screened. In a double-blinded crossover pilot-trial, sKOA participant (n = 30) were randomly assigned to either the Glu group (2000 mg day-1) or Aq+ (3056 mg day-1) for 12 weeks (clinicaltrials.gov:NCT03106584). The Knee Injury and Osteoarthritis Outcome Score was used to assess subjective pain and symptoms. Timed-up-and-Go (TuG) and Six minute walking distance were used to assess functional change and analgesic use was recorded.ResultsAq+ improved pain, with a large effect (P < 0.01, d’ = 0.73, 95%CI 0.201-1.265) and no change for Glu (d’ = 0.38, P = 0.06). Only Aq+ improved pain (P < 0.05) for males (d’ = 0.91, 95%CI 0.162-1.667) and females (d’ = 0.55, 95%CI 0.210-1.299). In females, Aq+ improved TuG by -7.02% (d’ = 0.92, 95%CI 1.699-0.141) while Glu worsened performance by 4.18% (P = 0.04). Aq+ reduced analgesia by 71.6%, compared to Glu (P = 0.02; d’ = 0.82, 95%CI 1.524-0.123). Aq+ was superior to Glu at improving pain, KOOS subscales, physical function and analgesia use in mild-sKOA. Given these data, Aq+ should be considered as a supplementary treatment for early-stage-KOA and may have the potential to reduce use of pain medication, although larger replication studies are required.
published_date 2020-05-01T04:06:38Z
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