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Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario

Davide Arillotta, Fabrizio Schifano, Flavia Napoletano, Caroline Zangani, Liam Gilgar, Amira Guirguis Orcid Logo, John Martin Corkery, Eugenio Aguglia, Alessandro Vento

Frontiers in Neuroscience, Volume: 14

Swansea University Author: Amira Guirguis Orcid Logo

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DOI (Published version): 10.3389/fnins.2020.00149

Abstract

Background: A wide range of novel psychoactive substances (NPSs) are regularly searched and discussed online by e-psychonauts. Among NPSs, the range of prescription/non-prescription opioids (fentanyl and non-fentanyl analogs) and herbal derivatives currently represents a challenge for governments an...

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Published in: Frontiers in Neuroscience
ISSN: 1662-453X
Published: Frontiers Media SA 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa53468
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spelling 2022-11-02T12:21:25.9852355 v2 53468 2020-02-07 Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario b49270b9a0d580cf4f31f9a1b6c93f87 0000-0001-8255-0660 Amira Guirguis Amira Guirguis true false 2020-02-07 PHAR Background: A wide range of novel psychoactive substances (NPSs) are regularly searched and discussed online by e-psychonauts. Among NPSs, the range of prescription/non-prescription opioids (fentanyl and non-fentanyl analogs) and herbal derivatives currently represents a challenge for governments and clinicians.Methods: Using a web crawler (i.e., NPS.Finder®), the present study aimed at assessing psychonaut fora/platforms to better understand the online situation regarding opioids.Results: The open-web crawling/navigating software identified some 426 opioids, including 234 fentanyl analogs. Of these, 176 substances (162 were very potent fentanyls, including two ohmefentanyl and seven carfentanyl analogs) were not listed in either international or European NPS databases.Conclusion: A web crawling approach helped in identifying a large number, indeed higher than that listed by European/international agencies, of unknown opioids likely to possess a significant misuse potential. Most of these novel/emerging substances are still relatively unknown. This is a reason of concern; each of these analogs potentially presents with different toxicodynamic profiles, and there is a lack of docking, preclinical, and clinical observations. Strengthening multidisciplinary collaboration between clinicians and bioinformatics may prove useful in better assessing public health risks associated with opioids. Journal Article Frontiers in Neuroscience 14 Frontiers Media SA 1662-453X psychonauts, novel psychoactive substance, novel synthetic opioids, fentanyl analogs, web crawling,drug misuse, prescribed drug misuse 18 3 2020 2020-03-18 10.3389/fnins.2020.00149 COLLEGE NANME Pharmacy COLLEGE CODE PHAR Swansea University 2022-11-02T12:21:25.9852355 2020-02-07T08:08:49.3206451 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Davide Arillotta 1 Fabrizio Schifano 2 Flavia Napoletano 3 Caroline Zangani 4 Liam Gilgar 5 Amira Guirguis 0000-0001-8255-0660 6 John Martin Corkery 7 Eugenio Aguglia 8 Alessandro Vento 9 53468__17330__7feee07a3c5a4d3c82efcd9701e3c8c4.pdf 53468VOR.pdf 2020-05-22T19:33:17.1352564 Output 375681 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution License (CC-BY). true eng http://creativecommons.org/licenses/by/4.0/
title Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario
spellingShingle Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario
Amira Guirguis
title_short Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario
title_full Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario
title_fullStr Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario
title_full_unstemmed Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario
title_sort Novel Opioids: Systematic Web Crawling Within the e-Psychonauts’ Scenario
author_id_str_mv b49270b9a0d580cf4f31f9a1b6c93f87
author_id_fullname_str_mv b49270b9a0d580cf4f31f9a1b6c93f87_***_Amira Guirguis
author Amira Guirguis
author2 Davide Arillotta
Fabrizio Schifano
Flavia Napoletano
Caroline Zangani
Liam Gilgar
Amira Guirguis
John Martin Corkery
Eugenio Aguglia
Alessandro Vento
format Journal article
container_title Frontiers in Neuroscience
container_volume 14
publishDate 2020
institution Swansea University
issn 1662-453X
doi_str_mv 10.3389/fnins.2020.00149
publisher Frontiers Media SA
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Background: A wide range of novel psychoactive substances (NPSs) are regularly searched and discussed online by e-psychonauts. Among NPSs, the range of prescription/non-prescription opioids (fentanyl and non-fentanyl analogs) and herbal derivatives currently represents a challenge for governments and clinicians.Methods: Using a web crawler (i.e., NPS.Finder®), the present study aimed at assessing psychonaut fora/platforms to better understand the online situation regarding opioids.Results: The open-web crawling/navigating software identified some 426 opioids, including 234 fentanyl analogs. Of these, 176 substances (162 were very potent fentanyls, including two ohmefentanyl and seven carfentanyl analogs) were not listed in either international or European NPS databases.Conclusion: A web crawling approach helped in identifying a large number, indeed higher than that listed by European/international agencies, of unknown opioids likely to possess a significant misuse potential. Most of these novel/emerging substances are still relatively unknown. This is a reason of concern; each of these analogs potentially presents with different toxicodynamic profiles, and there is a lack of docking, preclinical, and clinical observations. Strengthening multidisciplinary collaboration between clinicians and bioinformatics may prove useful in better assessing public health risks associated with opioids.
published_date 2020-03-18T04:06:24Z
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score 11.037056

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