Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

Yuan, Yifeng; Zallot, Remi; Grove, Tyler L.; Payan, Daniel J.; Martin-Verstraete, Isabelle; Šepić, Sara; Balamkundu, Seetharamsingh; Neelakandan, Ramesh; Gadi, Vinod K.; Liu, Chuan-Fa; Swairjo, Manal A.; Dedon, Peter C.; Almo, Steven C.; Gerlt, John A.; Crécy-Lagard, Valérie de

doi:10.1073/pnas.1909604116

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Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

Yifeng Yuan, Remi Zallot

, Tyler L. Grove, Daniel J. Payan, Isabelle Martin-Verstraete, Sara Šepić, Seetharamsingh Balamkundu, Ramesh Neelakandan, Vinod K. Gadi, Chuan-Fa Liu, Manal A. Swairjo, Peter C. Dedon, Steven C. Almo, John A. Gerlt, Valérie de Crécy-Lagard

Proceedings of the National Academy of Sciences, Volume: 116, Issue: 38, Pages: 19126 - 19135

Swansea University Author: Remi Zallot

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DOI (Published version): 10.1073/pnas.1909604116

Published in:	Proceedings of the National Academy of Sciences
ISSN:	0027-8424 1091-6490
Published:	Proceedings of the National Academy of Sciences 2019
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa53171

Keywords:	queuosine, nucleoside transport, sequence similarity network, comparative genomics, rSAM
College:	Faculty of Medicine, Health and Life Sciences
Funders:	This work was funded by the National Institutes of Health (R01 GM70641 to V.d.C.-L.; P01 GM118303 to J.A.G. and S.C.A.; U54-GM093342 to J.A.G. and S.C.A.; R21-AI133329 to T.L.G. and S.C.A.; U54-GM094662 to S.C.A.; GM110588 to M.A.S.), the Price Family Foundation (S.C.A.), and the California Metabolic Research Foundation (M.A.S.). We acknowledge the Albert Einstein Anaerobic Structural and Functional Genomics Resource (http://www.nysgxrc.org/psi3/anaerobic.html). We thank Martin I. H. McLauglin and Wilfred A. van der Donk for providing the guidance and the plasmid isc-pBADCDF for in vivo maturation of metalloenzymes. The LC-MS analyses were performed by Furong Sun at the Mass Spectrometry Laboratory, a Service Facility from the School of Chemical Sciences at University of Illinois at Urbana–Champaign. The Einstein Crystallographic Core X-Ray diffraction facility is supported by NIH Shared Instrumentation Grant S10 OD020068. This research used resources of the Advanced Photon Source, a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. Use of the Lilly Research Laboratories Collaborative Access Team (LRL-CAT) beamline at Sector 31 of the Advanced Photon Source was provided by Eli Lilly Company, which operates the facility.
Issue:	38
Start Page:	19126
End Page:	19135

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

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