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Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes

Martin Gill Orcid Logo, Jim A. Thomas

Ruthenium Complexes, Pages: 221 - 238

Swansea University Author: Martin Gill Orcid Logo

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DOI (Published version): 10.1002/9783527695225.ch11

Abstract

This chapter describes the development of kinetically inert ruthenium(II) polypyridyl complexes (RPCs) as cellular imaging agents and as potential therapeutics. By employing planar polypyridyl coordination ligands, these complexes may interact with DNA by a multitude of reversible binding mechanisms...

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Published in: Ruthenium Complexes
ISBN: 9783527339570 9783527695225
Published: Weinheim, Germany Wiley-VCH Verlag GmbH & Co. KGaA 2018
Online Access: http://dx.doi.org/10.1002/9783527695225.ch11
URI: https://cronfa.swan.ac.uk/Record/cronfa52957
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first_indexed 2019-12-04T13:17:15Z
last_indexed 2023-01-11T14:30:20Z
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spelling 2022-11-16T13:49:57.5704839 v2 52957 2019-12-04 Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes 485d85b532851e8863cd19c6af7e00f7 0000-0002-1371-5676 Martin Gill Martin Gill true false 2019-12-04 CHEM This chapter describes the development of kinetically inert ruthenium(II) polypyridyl complexes (RPCs) as cellular imaging agents and as potential therapeutics. By employing planar polypyridyl coordination ligands, these complexes may interact with DNA by a multitude of reversible binding mechanisms, often with distinctive photophysical changes upon association. We discuss the chemical and biological approaches employed to promote cellular uptake and successful intracellular DNA targeting for complexes that bind DNA with high affinities and specificities. We describe the progress made in the past decade by leading researchers, citing recent examples of primary research in the literature. In addition to this, several milestone papers and key reviews are highlighted to provide wider context and further reading. Finally, we examine how this developing knowledge may provide an indication for future biomedical applications for this exciting area of ruthenium chemistry. Book chapter Ruthenium Complexes 221 238 Wiley-VCH Verlag GmbH & Co. KGaA Weinheim, Germany 9783527339570 9783527695225 ruthenium(II), polypyridyl, DNA, luminescence, microscopy 3 1 2018 2018-01-03 10.1002/9783527695225.ch11 http://dx.doi.org/10.1002/9783527695225.ch11 COLLEGE NANME Chemistry COLLEGE CODE CHEM Swansea University 2022-11-16T13:49:57.5704839 2019-12-04T09:31:23.3951850 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Martin Gill 0000-0002-1371-5676 1 Jim A. Thomas 2
title Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes
spellingShingle Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes
Martin Gill
title_short Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes
title_full Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes
title_fullStr Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes
title_full_unstemmed Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes
title_sort Targeting cellular DNA with Luminescent Ruthenium(II) Polypyridyl Complexes
author_id_str_mv 485d85b532851e8863cd19c6af7e00f7
author_id_fullname_str_mv 485d85b532851e8863cd19c6af7e00f7_***_Martin Gill
author Martin Gill
author2 Martin Gill
Jim A. Thomas
format Book chapter
container_title Ruthenium Complexes
container_start_page 221
publishDate 2018
institution Swansea University
isbn 9783527339570
9783527695225
doi_str_mv 10.1002/9783527695225.ch11
publisher Wiley-VCH Verlag GmbH & Co. KGaA
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
url http://dx.doi.org/10.1002/9783527695225.ch11
document_store_str 0
active_str 0
description This chapter describes the development of kinetically inert ruthenium(II) polypyridyl complexes (RPCs) as cellular imaging agents and as potential therapeutics. By employing planar polypyridyl coordination ligands, these complexes may interact with DNA by a multitude of reversible binding mechanisms, often with distinctive photophysical changes upon association. We discuss the chemical and biological approaches employed to promote cellular uptake and successful intracellular DNA targeting for complexes that bind DNA with high affinities and specificities. We describe the progress made in the past decade by leading researchers, citing recent examples of primary research in the literature. In addition to this, several milestone papers and key reviews are highlighted to provide wider context and further reading. Finally, we examine how this developing knowledge may provide an indication for future biomedical applications for this exciting area of ruthenium chemistry.
published_date 2018-01-03T04:05:39Z
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score 11.013731

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