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Differential immunity as a factor influencing mussel hybrid zone structure

Deryk Tolman, Hannah L. Wood, David Skibinski Orcid Logo, Manuela Truebano

Marine Biology, Volume: 166, Issue: 12

Swansea University Author: David Skibinski Orcid Logo

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DOI (Published version): 10.1007/s00227-019-3604-3

Abstract

Interspecific hybridisation can alter fitness-related traits, including the response to pathogens, yet immunity is rarely investigated as a potential driver of hybrid zone dynamics, particularly in invertebrates. We investigated the immune response of mussels from a sympatric population at Croyde Ba...

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Published in: Marine Biology
ISSN: 0025-3162 1432-1793
Published: Springer Science and Business Media LLC 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa52706
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first_indexed 2019-11-12T04:13:48Z
last_indexed 2020-11-21T04:07:05Z
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spelling 2020-11-20T12:38:43.9369358 v2 52706 2019-11-11 Differential immunity as a factor influencing mussel hybrid zone structure 328d16903f98c2b03a1cc64a7530322a 0000-0003-4077-6236 David Skibinski David Skibinski true false 2019-11-11 SGMED Interspecific hybridisation can alter fitness-related traits, including the response to pathogens, yet immunity is rarely investigated as a potential driver of hybrid zone dynamics, particularly in invertebrates. We investigated the immune response of mussels from a sympatric population at Croyde Bay, within the hybrid zone of Mytilus edulis and Mytilus galloprovincialis in Southwest England. The site is characterised by size-dependent variation in genotype frequencies, with a higher frequency of M. galloprovincialis alleles in large mussels, largely attributed to selective mortality in favour of the M. galloprovincialis genotype. To determine if differences in immune response may contribute to this size-dependent variation in genotype frequencies, we assessed the two pure species and their hybrids in their phagocytic abilities when subject to immune challenge as a measure of immunocompetence and measured the metabolic cost of mounting an antigen-stimulated immune response. Mussels identified as M. galloprovincialis had a greater immunocompetence response at a lower metabolic cost compared to mussels identified as M. edulis. Mussels identified as hybrids had intermediate values for both parameters, providing no evidence for heterosis but suggesting that increased susceptibility compared to M. galloprovincialis may be attributed to the M. edulis genotype. The results indicate phenotypic differences in the face of pathogenic infection, which may be a contributing factor to the differential mortality in favour of M. galloprovincialis, and the size-dependent variation in genotype frequencies associated with this contact zone. We propose that immunity may contribute to European mussel hybrid zone dynamics. Journal Article Marine Biology 166 12 Springer Science and Business Media LLC 0025-3162 1432-1793 1 12 2019 2019-12-01 10.1007/s00227-019-3604-3 COLLEGE NANME Medical School - School COLLEGE CODE SGMED Swansea University 2020-11-20T12:38:43.9369358 2019-11-11T20:45:56.8926246 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Deryk Tolman 1 Hannah L. Wood 2 David Skibinski 0000-0003-4077-6236 3 Manuela Truebano 4 52706__15937__451ee5aba93f4c91bf6c2c7c514b5205.pdf 52706.pdf 2019-11-21T15:55:05.1617935 Output 452154 application/pdf Accepted Manuscript true 2020-11-04T00:00:00.0000000 true eng
title Differential immunity as a factor influencing mussel hybrid zone structure
spellingShingle Differential immunity as a factor influencing mussel hybrid zone structure
David Skibinski
title_short Differential immunity as a factor influencing mussel hybrid zone structure
title_full Differential immunity as a factor influencing mussel hybrid zone structure
title_fullStr Differential immunity as a factor influencing mussel hybrid zone structure
title_full_unstemmed Differential immunity as a factor influencing mussel hybrid zone structure
title_sort Differential immunity as a factor influencing mussel hybrid zone structure
author_id_str_mv 328d16903f98c2b03a1cc64a7530322a
author_id_fullname_str_mv 328d16903f98c2b03a1cc64a7530322a_***_David Skibinski
author David Skibinski
author2 Deryk Tolman
Hannah L. Wood
David Skibinski
Manuela Truebano
format Journal article
container_title Marine Biology
container_volume 166
container_issue 12
publishDate 2019
institution Swansea University
issn 0025-3162
1432-1793
doi_str_mv 10.1007/s00227-019-3604-3
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Interspecific hybridisation can alter fitness-related traits, including the response to pathogens, yet immunity is rarely investigated as a potential driver of hybrid zone dynamics, particularly in invertebrates. We investigated the immune response of mussels from a sympatric population at Croyde Bay, within the hybrid zone of Mytilus edulis and Mytilus galloprovincialis in Southwest England. The site is characterised by size-dependent variation in genotype frequencies, with a higher frequency of M. galloprovincialis alleles in large mussels, largely attributed to selective mortality in favour of the M. galloprovincialis genotype. To determine if differences in immune response may contribute to this size-dependent variation in genotype frequencies, we assessed the two pure species and their hybrids in their phagocytic abilities when subject to immune challenge as a measure of immunocompetence and measured the metabolic cost of mounting an antigen-stimulated immune response. Mussels identified as M. galloprovincialis had a greater immunocompetence response at a lower metabolic cost compared to mussels identified as M. edulis. Mussels identified as hybrids had intermediate values for both parameters, providing no evidence for heterosis but suggesting that increased susceptibility compared to M. galloprovincialis may be attributed to the M. edulis genotype. The results indicate phenotypic differences in the face of pathogenic infection, which may be a contributing factor to the differential mortality in favour of M. galloprovincialis, and the size-dependent variation in genotype frequencies associated with this contact zone. We propose that immunity may contribute to European mussel hybrid zone dynamics.
published_date 2019-12-01T04:05:14Z
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score 11.013148

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