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Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence

Jon Brazier, Mark Antrobus, Georgina Stebbings, Stephen Day, Shane Heffernan Orcid Logo, Matthew Cross, Alun Williams

Sports, Volume: 7, Issue: 6, Start page: 138

Swansea University Author: Shane Heffernan Orcid Logo

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DOI (Published version): 10.3390/sports7060138

Abstract

This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest rep...

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Published in: Sports
ISSN: 2075-4663
Published: 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa51434
first_indexed 2019-08-16T15:30:32Z
last_indexed 2019-09-02T20:45:58Z
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recordtype SURis
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spelling 2019-09-02T16:06:46.9860666 v2 51434 2019-08-16 Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false 2019-08-16 EAAS This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest reported injury incidences of any professional sport. This is likely due to a combination of well-established injury surveillance systems and the characteristics of the game, whereby high-impact body contact frequently occurs, in addition to the high intensity, multispeed and multidirectional nature of play. Some of the most severe of all these injuries are tendon and ligament/joint (non-bone), and therefore, potentially the most debilitating to a player and playing squad across a season or World Cup competition. The aetiology of these injuries is highly multi-factorial, with a growing body of evidence suggesting that some of the inter-individual variability in injury susceptibility may be due to genetic variation. However, little effort has been devoted to the study of genetic injury traits within rugby athletes. Due to a growing understanding of the molecular characteristics underpinning the aetiology of injury, investigating genetic variation within elite rugby is a viable and worthy proposition. Therefore, we propose several single nucleotide polymorphisms within candidate genes of interest; COL1A1, COL3A1, COL5A1, MIR608, MMP3, TIMP2, VEGFA, NID1 and COLGALT1 warrant further study within elite rugby and other invasion sports. Journal Article Sports 7 6 138 2075-4663 genomics; rugby; polymorphisms; soft-tissue injury; tendinopathy; ligament rupture 31 12 2019 2019-12-31 10.3390/sports7060138 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2019-09-02T16:06:46.9860666 2019-08-16T10:48:48.2462397 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Jon Brazier 1 Mark Antrobus 2 Georgina Stebbings 3 Stephen Day 4 Shane Heffernan 0000-0002-3297-9335 5 Matthew Cross 6 Alun Williams 7 0051434-02092019160611.pdf brazier2019.pdf 2019-09-02T16:06:11.7570000 Output 870230 application/pdf Version of Record true 2019-09-02T00:00:00.0000000 false eng
title Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
spellingShingle Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
Shane Heffernan
title_short Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
title_full Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
title_fullStr Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
title_full_unstemmed Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
title_sort Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
author_id_str_mv 72c0b36891dfbec0378c0d0f7916e807
author_id_fullname_str_mv 72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan
author Shane Heffernan
author2 Jon Brazier
Mark Antrobus
Georgina Stebbings
Stephen Day
Shane Heffernan
Matthew Cross
Alun Williams
format Journal article
container_title Sports
container_volume 7
container_issue 6
container_start_page 138
publishDate 2019
institution Swansea University
issn 2075-4663
doi_str_mv 10.3390/sports7060138
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
active_str 0
description This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest reported injury incidences of any professional sport. This is likely due to a combination of well-established injury surveillance systems and the characteristics of the game, whereby high-impact body contact frequently occurs, in addition to the high intensity, multispeed and multidirectional nature of play. Some of the most severe of all these injuries are tendon and ligament/joint (non-bone), and therefore, potentially the most debilitating to a player and playing squad across a season or World Cup competition. The aetiology of these injuries is highly multi-factorial, with a growing body of evidence suggesting that some of the inter-individual variability in injury susceptibility may be due to genetic variation. However, little effort has been devoted to the study of genetic injury traits within rugby athletes. Due to a growing understanding of the molecular characteristics underpinning the aetiology of injury, investigating genetic variation within elite rugby is a viable and worthy proposition. Therefore, we propose several single nucleotide polymorphisms within candidate genes of interest; COL1A1, COL3A1, COL5A1, MIR608, MMP3, TIMP2, VEGFA, NID1 and COLGALT1 warrant further study within elite rugby and other invasion sports.
published_date 2019-12-31T13:49:42Z
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score 11.04748

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