No Cover Image

Journal article 1035 views 251 downloads

Simulations on an undamped electromechanical vibration of microtubules in cytosol

Si Li, Chengyuan Wang Orcid Logo, Perumal Nithiarasu Orcid Logo

Applied Physics Letters, Volume: 114, Issue: 25, Start page: 253702

Swansea University Authors: Chengyuan Wang Orcid Logo, Perumal Nithiarasu Orcid Logo

Check full text

DOI (Published version): 10.1063/1.5097204

Abstract

This letter aims to study the electromechanical vibration of microtubules submerged in cytosol. The microtubule-cytosol interface is established in molecular dynamics simulations, and the electrically excited vibrations of microtubules in cytosol are studied based on a molecular mechanics model. The...

Full description

Published in: Applied Physics Letters
ISSN: 0003-6951 1077-3118
Published: 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa50887
first_indexed 2019-06-19T20:52:48Z
last_indexed 2019-07-13T05:38:58Z
id cronfa50887
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-07-11T09:52:54.3487208</datestamp><bib-version>v2</bib-version><id>50887</id><entry>2019-06-19</entry><title>Simulations on an undamped electromechanical vibration of microtubules in cytosol</title><swanseaauthors><author><sid>fdea93ab99f51d0b3921d3601876c1e5</sid><ORCID>0000-0002-1001-2537</ORCID><firstname>Chengyuan</firstname><surname>Wang</surname><name>Chengyuan Wang</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>3b28bf59358fc2b9bd9a46897dbfc92d</sid><ORCID>0000-0002-4901-2980</ORCID><firstname>Perumal</firstname><surname>Nithiarasu</surname><name>Perumal Nithiarasu</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-06-19</date><deptcode>ACEM</deptcode><abstract>This letter aims to study the electromechanical vibration of microtubules submerged in cytosol. The microtubule-cytosol interface is established in molecular dynamics simulations, and the electrically excited vibrations of microtubules in cytosol are studied based on a molecular mechanics model. The simulations show that the solid-liquid interface with a nanoscale gap significantly reduces the viscous damping of cytosol on microtubule vibration. Specifically, as far as the radial breathing modes are concerned, cytosol behaves nearly as a rigid body and thus has a very small damping effect on the radial breathing mode of microtubules. This distinctive feature of the radial breathing modes arises from its extremely small amplitude (&lt;0.1&#x2009;&#xC5;), and the relatively large gap between microtubules and cytosol (2.5&#x2009;&#xC5;) is due to the van der Waals interaction. Such a nearly undamped megahertz microtubule vibration excited by an electrical magnetic field may play an important role in designing microtubule-based biosensors, developing novel treatments of diseases, and facilitating signal transduction in cells.</abstract><type>Journal Article</type><journal>Applied Physics Letters</journal><volume>114</volume><journalNumber>25</journalNumber><paginationStart>253702</paginationStart><publisher/><issnPrint>0003-6951</issnPrint><issnElectronic>1077-3118</issnElectronic><keywords/><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-12-31</publishedDate><doi>10.1063/1.5097204</doi><url/><notes/><college>COLLEGE NANME</college><department>Aerospace, Civil, Electrical, and Mechanical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>ACEM</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-07-11T09:52:54.3487208</lastEdited><Created>2019-06-19T14:59:46.3515915</Created><authors><author><firstname>Si</firstname><surname>Li</surname><order>1</order></author><author><firstname>Chengyuan</firstname><surname>Wang</surname><orcid>0000-0002-1001-2537</orcid><order>2</order></author><author><firstname>Perumal</firstname><surname>Nithiarasu</surname><orcid>0000-0002-4901-2980</orcid><order>3</order></author></authors><documents><document><filename>0050887-11072019095207.pdf</filename><originalFilename>li2019(7)v2.pdf</originalFilename><uploaded>2019-07-11T09:52:07.3400000</uploaded><type>Output</type><contentLength>5640327</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-07-11T00:00:00.0000000</embargoDate><copyrightCorrect>false</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2019-07-11T09:52:54.3487208 v2 50887 2019-06-19 Simulations on an undamped electromechanical vibration of microtubules in cytosol fdea93ab99f51d0b3921d3601876c1e5 0000-0002-1001-2537 Chengyuan Wang Chengyuan Wang true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2019-06-19 ACEM This letter aims to study the electromechanical vibration of microtubules submerged in cytosol. The microtubule-cytosol interface is established in molecular dynamics simulations, and the electrically excited vibrations of microtubules in cytosol are studied based on a molecular mechanics model. The simulations show that the solid-liquid interface with a nanoscale gap significantly reduces the viscous damping of cytosol on microtubule vibration. Specifically, as far as the radial breathing modes are concerned, cytosol behaves nearly as a rigid body and thus has a very small damping effect on the radial breathing mode of microtubules. This distinctive feature of the radial breathing modes arises from its extremely small amplitude (<0.1 Å), and the relatively large gap between microtubules and cytosol (2.5 Å) is due to the van der Waals interaction. Such a nearly undamped megahertz microtubule vibration excited by an electrical magnetic field may play an important role in designing microtubule-based biosensors, developing novel treatments of diseases, and facilitating signal transduction in cells. Journal Article Applied Physics Letters 114 25 253702 0003-6951 1077-3118 31 12 2019 2019-12-31 10.1063/1.5097204 COLLEGE NANME Aerospace, Civil, Electrical, and Mechanical Engineering COLLEGE CODE ACEM Swansea University 2019-07-11T09:52:54.3487208 2019-06-19T14:59:46.3515915 Si Li 1 Chengyuan Wang 0000-0002-1001-2537 2 Perumal Nithiarasu 0000-0002-4901-2980 3 0050887-11072019095207.pdf li2019(7)v2.pdf 2019-07-11T09:52:07.3400000 Output 5640327 application/pdf Version of Record true 2019-07-11T00:00:00.0000000 false eng
title Simulations on an undamped electromechanical vibration of microtubules in cytosol
spellingShingle Simulations on an undamped electromechanical vibration of microtubules in cytosol
Chengyuan Wang
Perumal Nithiarasu
title_short Simulations on an undamped electromechanical vibration of microtubules in cytosol
title_full Simulations on an undamped electromechanical vibration of microtubules in cytosol
title_fullStr Simulations on an undamped electromechanical vibration of microtubules in cytosol
title_full_unstemmed Simulations on an undamped electromechanical vibration of microtubules in cytosol
title_sort Simulations on an undamped electromechanical vibration of microtubules in cytosol
author_id_str_mv fdea93ab99f51d0b3921d3601876c1e5
3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv fdea93ab99f51d0b3921d3601876c1e5_***_Chengyuan Wang
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Chengyuan Wang
Perumal Nithiarasu
author2 Si Li
Chengyuan Wang
Perumal Nithiarasu
format Journal article
container_title Applied Physics Letters
container_volume 114
container_issue 25
container_start_page 253702
publishDate 2019
institution Swansea University
issn 0003-6951
1077-3118
doi_str_mv 10.1063/1.5097204
document_store_str 1
active_str 0
description This letter aims to study the electromechanical vibration of microtubules submerged in cytosol. The microtubule-cytosol interface is established in molecular dynamics simulations, and the electrically excited vibrations of microtubules in cytosol are studied based on a molecular mechanics model. The simulations show that the solid-liquid interface with a nanoscale gap significantly reduces the viscous damping of cytosol on microtubule vibration. Specifically, as far as the radial breathing modes are concerned, cytosol behaves nearly as a rigid body and thus has a very small damping effect on the radial breathing mode of microtubules. This distinctive feature of the radial breathing modes arises from its extremely small amplitude (<0.1 Å), and the relatively large gap between microtubules and cytosol (2.5 Å) is due to the van der Waals interaction. Such a nearly undamped megahertz microtubule vibration excited by an electrical magnetic field may play an important role in designing microtubule-based biosensors, developing novel treatments of diseases, and facilitating signal transduction in cells.
published_date 2019-12-31T07:33:59Z
_version_ 1829268136568815616
score 11.0578165

Similar Items