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Simulations on an undamped electromechanical vibration of microtubules in cytosol

Si Li, Chengyuan Wang Orcid Logo, Perumal Nithiarasu Orcid Logo

Applied Physics Letters, Volume: 114, Issue: 25, Start page: 253702

Swansea University Authors: Chengyuan Wang Orcid Logo, Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1063/1.5097204

Abstract

This letter aims to study the electromechanical vibration of microtubules submerged in cytosol. The microtubule-cytosol interface is established in molecular dynamics simulations, and the electrically excited vibrations of microtubules in cytosol are studied based on a molecular mechanics model. The...

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Published in: Applied Physics Letters
ISSN: 0003-6951 1077-3118
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa50887
first_indexed 2019-06-19T20:52:48Z
last_indexed 2019-07-13T05:38:58Z
id cronfa50887
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spelling 2019-07-11T09:52:54.3487208 v2 50887 2019-06-19 Simulations on an undamped electromechanical vibration of microtubules in cytosol fdea93ab99f51d0b3921d3601876c1e5 0000-0002-1001-2537 Chengyuan Wang Chengyuan Wang true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2019-06-19 ACEM This letter aims to study the electromechanical vibration of microtubules submerged in cytosol. The microtubule-cytosol interface is established in molecular dynamics simulations, and the electrically excited vibrations of microtubules in cytosol are studied based on a molecular mechanics model. The simulations show that the solid-liquid interface with a nanoscale gap significantly reduces the viscous damping of cytosol on microtubule vibration. Specifically, as far as the radial breathing modes are concerned, cytosol behaves nearly as a rigid body and thus has a very small damping effect on the radial breathing mode of microtubules. This distinctive feature of the radial breathing modes arises from its extremely small amplitude (<0.1 Å), and the relatively large gap between microtubules and cytosol (2.5 Å) is due to the van der Waals interaction. Such a nearly undamped megahertz microtubule vibration excited by an electrical magnetic field may play an important role in designing microtubule-based biosensors, developing novel treatments of diseases, and facilitating signal transduction in cells. Journal Article Applied Physics Letters 114 25 253702 0003-6951 1077-3118 31 12 2019 2019-12-31 10.1063/1.5097204 COLLEGE NANME Aerospace, Civil, Electrical, and Mechanical Engineering COLLEGE CODE ACEM Swansea University 2019-07-11T09:52:54.3487208 2019-06-19T14:59:46.3515915 Si Li 1 Chengyuan Wang 0000-0002-1001-2537 2 Perumal Nithiarasu 0000-0002-4901-2980 3 0050887-11072019095207.pdf li2019(7)v2.pdf 2019-07-11T09:52:07.3400000 Output 5640327 application/pdf Version of Record true 2019-07-11T00:00:00.0000000 false eng
title Simulations on an undamped electromechanical vibration of microtubules in cytosol
spellingShingle Simulations on an undamped electromechanical vibration of microtubules in cytosol
Chengyuan Wang
Perumal Nithiarasu
title_short Simulations on an undamped electromechanical vibration of microtubules in cytosol
title_full Simulations on an undamped electromechanical vibration of microtubules in cytosol
title_fullStr Simulations on an undamped electromechanical vibration of microtubules in cytosol
title_full_unstemmed Simulations on an undamped electromechanical vibration of microtubules in cytosol
title_sort Simulations on an undamped electromechanical vibration of microtubules in cytosol
author_id_str_mv fdea93ab99f51d0b3921d3601876c1e5
3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv fdea93ab99f51d0b3921d3601876c1e5_***_Chengyuan Wang
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Chengyuan Wang
Perumal Nithiarasu
author2 Si Li
Chengyuan Wang
Perumal Nithiarasu
format Journal article
container_title Applied Physics Letters
container_volume 114
container_issue 25
container_start_page 253702
publishDate 2019
institution Swansea University
issn 0003-6951
1077-3118
doi_str_mv 10.1063/1.5097204
document_store_str 1
active_str 0
description This letter aims to study the electromechanical vibration of microtubules submerged in cytosol. The microtubule-cytosol interface is established in molecular dynamics simulations, and the electrically excited vibrations of microtubules in cytosol are studied based on a molecular mechanics model. The simulations show that the solid-liquid interface with a nanoscale gap significantly reduces the viscous damping of cytosol on microtubule vibration. Specifically, as far as the radial breathing modes are concerned, cytosol behaves nearly as a rigid body and thus has a very small damping effect on the radial breathing mode of microtubules. This distinctive feature of the radial breathing modes arises from its extremely small amplitude (<0.1 Å), and the relatively large gap between microtubules and cytosol (2.5 Å) is due to the van der Waals interaction. Such a nearly undamped megahertz microtubule vibration excited by an electrical magnetic field may play an important role in designing microtubule-based biosensors, developing novel treatments of diseases, and facilitating signal transduction in cells.
published_date 2019-12-31T07:34:27Z
_version_ 1828271598792081408
score 11.056981

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