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Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel

Francesco Del Giudice Orcid Logo

Microfluidics and Nanofluidics, Volume: 23, Issue: 7

Swansea University Author: Francesco Del Giudice Orcid Logo

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DOI (Published version): 10.1007/s10404-019-2263-5

Abstract

Flow cytometry is a technique for the analysis of cells and particles by coupling a sheath flow assisted focusing microfluidic device to an optical or electrical reader. In this context, polymer solutions can be employed to drive particle and cell focusing on the centreline of simple straight microf...

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Published in: Microfluidics and Nanofluidics
ISSN: 1613-4982 1613-4990
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa50885
first_indexed 2019-06-19T20:52:48Z
last_indexed 2019-07-03T20:53:41Z
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spelling 2019-07-03T15:49:17.2312016 v2 50885 2019-06-19 Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2019-06-19 EAAS Flow cytometry is a technique for the analysis of cells and particles by coupling a sheath flow assisted focusing microfluidic device to an optical or electrical reader. In this context, polymer solutions can be employed to drive particle and cell focusing on the centreline of simple straight microfluidic channels. However, the change of the focusing efficiency due to polydispersity, which is a rule rather than the exception across cell populations, has not been extensively studied yet. In this work, the effect of particle polydispersity on the viscoelastic focusing in a straight cylindrical microchannel was studied by preparing two particle suspensions, containing different concentrations of particles with average diameters of 10μm , 15μm and 20μm , suspended in three solutions of polyethylene oxide with mass concentrations of 0.1 wt%, 0.25 wt% and 0.5 wt%. When the fluid explored the constant-viscosity region of the rheological curve, up to 95% of the particles were aligned on the channel centreline. When the fluid explored the shear-thinning region of the rheological curve, centreline focusing efficiency decreased, with the highest value of aligned particles being of 60%. For both mixtures, it was also observed that the fraction of aligned particles in a polydisperse system was not equivalent to that derived from the estimate of independent experiments with monodisperse particles. Journal Article Microfluidics and Nanofluidics 23 7 1613-4982 1613-4990 Microfluidic, Viscoelastic, Polydisperse, 3D focusing, Alignment 31 12 2019 2019-12-31 10.1007/s10404-019-2263-5 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2019-07-03T15:49:17.2312016 2019-06-19T14:28:59.3891860 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Francesco Del Giudice 0000-0002-9414-6937 1 0050885-03072019154839.pdf DelGiudice2019(2).pdf 2019-07-03T15:48:39.2270000 Output 2234039 application/pdf Version of Record true 2019-07-03T00:00:00.0000000 false eng
title Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel
spellingShingle Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel
Francesco Del Giudice
title_short Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel
title_full Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel
title_fullStr Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel
title_full_unstemmed Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel
title_sort Viscoelastic focusing of polydisperse particle suspensions in a straight circular microchannel
author_id_str_mv 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv 742d483071479b44d7888e16166b1309_***_Francesco Del Giudice
author Francesco Del Giudice
author2 Francesco Del Giudice
format Journal article
container_title Microfluidics and Nanofluidics
container_volume 23
container_issue 7
publishDate 2019
institution Swansea University
issn 1613-4982
1613-4990
doi_str_mv 10.1007/s10404-019-2263-5
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description Flow cytometry is a technique for the analysis of cells and particles by coupling a sheath flow assisted focusing microfluidic device to an optical or electrical reader. In this context, polymer solutions can be employed to drive particle and cell focusing on the centreline of simple straight microfluidic channels. However, the change of the focusing efficiency due to polydispersity, which is a rule rather than the exception across cell populations, has not been extensively studied yet. In this work, the effect of particle polydispersity on the viscoelastic focusing in a straight cylindrical microchannel was studied by preparing two particle suspensions, containing different concentrations of particles with average diameters of 10μm , 15μm and 20μm , suspended in three solutions of polyethylene oxide with mass concentrations of 0.1 wt%, 0.25 wt% and 0.5 wt%. When the fluid explored the constant-viscosity region of the rheological curve, up to 95% of the particles were aligned on the channel centreline. When the fluid explored the shear-thinning region of the rheological curve, centreline focusing efficiency decreased, with the highest value of aligned particles being of 60%. For both mixtures, it was also observed that the fraction of aligned particles in a polydisperse system was not equivalent to that derived from the estimate of independent experiments with monodisperse particles.
published_date 2019-12-31T07:45:56Z
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score 11.364387

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