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The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina

Rachel Churm Orcid Logo, T Oliver, SJ Hurel, SE Humphries, JW Stephens, SL Prior, Sarah Prior Orcid Logo

Journal of Diabetes & Metabolism, Volume: 7, Issue: 7

Swansea University Authors: Rachel Churm Orcid Logo, Sarah Prior Orcid Logo

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DOI (Published version): 10.4172/2155-6156.1000686

Abstract

Background & Aims: Cycloxygenase-2 (COX-2) catalyses the rate limiting step of prostaglandin biosynthesis. Despite previous studies, it is still unclear whether COX-2 is beneficial or detrimental to cardiovascular risk. The aim of this study was to examine the -765G>C (rs20417) PTGS2 promoter...

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Published in: Journal of Diabetes & Metabolism
ISSN: 21556156
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa50671
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-06-18T08:52:51.6958150</datestamp><bib-version>v2</bib-version><id>50671</id><entry>2019-06-06</entry><title>The -765G&gt;C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina</title><swanseaauthors><author><sid>c6cd8267ff0b13f2ea333bbfefdae144</sid><ORCID>0000-0001-9855-6282</ORCID><firstname>Rachel</firstname><surname>Churm</surname><name>Rachel Churm</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>cdda101035997acfaa6fdf17097f52b2</sid><ORCID>0000-0001-8703-8092</ORCID><firstname>Sarah</firstname><surname>Prior</surname><name>Sarah Prior</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-06-06</date><deptcode>STSC</deptcode><abstract>Background &amp; Aims: Cycloxygenase-2 (COX-2) catalyses the rate limiting step of prostaglandin biosynthesis. Despite previous studies, it is still unclear whether COX-2 is beneficial or detrimental to cardiovascular risk. The aim of this study was to examine the -765G&gt;C (rs20417) PTGS2 promoter gene variant, which encodes COX-2, in relation to markers of cardiovascular risk in a sample of well-characterised subjects with diabetes mellitus. Methods &amp; Results: We observed that the CC genotype was more prevalent in Type 2 diabetes mellitus compared to Type 1 (84.2 vs 15.8%; p&#x2264;0.05), and was significantly associated with clinically manifest angina (GG vs GC vs CC: 14.3% vs 15.6% vs 28.0%; p=0.009) and lower HDL-cholesterol levels (GG vs GC vs CC: 1.3mmol/L vs 1.4mmol/L vs 1.2mmol/L; p=0.032). This is in line with previous studies showing that -765G&gt;C genotype variant alters Sp1 binding, resulting in decreased COX-2 activity which is associated with atherosclerosis. Conclusion: We conclude that the CC genotype may contribute to a reduction of prostaglandin E2 mediated insulin secretion, predisposing those individuals to Type 2 diabetes mellitus. Further prospective work is warranted in order to examine the association between COX-2 and cardiovascular risk.</abstract><type>Journal Article</type><journal>Journal of Diabetes &amp; Metabolism</journal><volume>7</volume><journalNumber>7</journalNumber><publisher/><issnElectronic>21556156</issnElectronic><keywords>COX-2; polymorphism; Type 2 diabetes; HDL; angina; cardiovascular</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2016</publishedYear><publishedDate>2016-12-31</publishedDate><doi>10.4172/2155-6156.1000686</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-06-18T08:52:51.6958150</lastEdited><Created>2019-06-06T09:57:30.9921084</Created><path><level id="1">Faculty of Medicine, Health and Life Sciences</level><level id="2">Swansea University Medical School - Medicine</level></path><authors><author><firstname>Rachel</firstname><surname>Churm</surname><orcid>0000-0001-9855-6282</orcid><order>1</order></author><author><firstname>T</firstname><surname>Oliver</surname><order>2</order></author><author><firstname>SJ</firstname><surname>Hurel</surname><order>3</order></author><author><firstname>SE</firstname><surname>Humphries</surname><order>4</order></author><author><firstname>JW</firstname><surname>Stephens</surname><order>5</order></author><author><firstname>SL</firstname><surname>Prior</surname><order>6</order></author><author><firstname>Sarah</firstname><surname>Prior</surname><orcid>0000-0001-8703-8092</orcid><order>7</order></author></authors><documents><document><filename>0050671-18062019085029.pdf</filename><originalFilename>50671.pdf</originalFilename><uploaded>2019-06-18T08:50:29.8530000</uploaded><type>Output</type><contentLength>325608</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-06-17T00:00:00.0000000</embargoDate><documentNotes>Released under the terms of a Creative Commons Attribution License (CC-BY).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2019-06-18T08:52:51.6958150 v2 50671 2019-06-06 The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina c6cd8267ff0b13f2ea333bbfefdae144 0000-0001-9855-6282 Rachel Churm Rachel Churm true false cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false 2019-06-06 STSC Background & Aims: Cycloxygenase-2 (COX-2) catalyses the rate limiting step of prostaglandin biosynthesis. Despite previous studies, it is still unclear whether COX-2 is beneficial or detrimental to cardiovascular risk. The aim of this study was to examine the -765G>C (rs20417) PTGS2 promoter gene variant, which encodes COX-2, in relation to markers of cardiovascular risk in a sample of well-characterised subjects with diabetes mellitus. Methods & Results: We observed that the CC genotype was more prevalent in Type 2 diabetes mellitus compared to Type 1 (84.2 vs 15.8%; p≤0.05), and was significantly associated with clinically manifest angina (GG vs GC vs CC: 14.3% vs 15.6% vs 28.0%; p=0.009) and lower HDL-cholesterol levels (GG vs GC vs CC: 1.3mmol/L vs 1.4mmol/L vs 1.2mmol/L; p=0.032). This is in line with previous studies showing that -765G>C genotype variant alters Sp1 binding, resulting in decreased COX-2 activity which is associated with atherosclerosis. Conclusion: We conclude that the CC genotype may contribute to a reduction of prostaglandin E2 mediated insulin secretion, predisposing those individuals to Type 2 diabetes mellitus. Further prospective work is warranted in order to examine the association between COX-2 and cardiovascular risk. Journal Article Journal of Diabetes & Metabolism 7 7 21556156 COX-2; polymorphism; Type 2 diabetes; HDL; angina; cardiovascular 31 12 2016 2016-12-31 10.4172/2155-6156.1000686 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2019-06-18T08:52:51.6958150 2019-06-06T09:57:30.9921084 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Rachel Churm 0000-0001-9855-6282 1 T Oliver 2 SJ Hurel 3 SE Humphries 4 JW Stephens 5 SL Prior 6 Sarah Prior 0000-0001-8703-8092 7 0050671-18062019085029.pdf 50671.pdf 2019-06-18T08:50:29.8530000 Output 325608 application/pdf Version of Record true 2019-06-17T00:00:00.0000000 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng
title The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
spellingShingle The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
Rachel Churm
Sarah Prior
title_short The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
title_full The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
title_fullStr The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
title_full_unstemmed The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
title_sort The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
author_id_str_mv c6cd8267ff0b13f2ea333bbfefdae144
cdda101035997acfaa6fdf17097f52b2
author_id_fullname_str_mv c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel Churm
cdda101035997acfaa6fdf17097f52b2_***_Sarah Prior
author Rachel Churm
Sarah Prior
author2 Rachel Churm
T Oliver
SJ Hurel
SE Humphries
JW Stephens
SL Prior
Sarah Prior
format Journal article
container_title Journal of Diabetes & Metabolism
container_volume 7
container_issue 7
publishDate 2016
institution Swansea University
issn 21556156
doi_str_mv 10.4172/2155-6156.1000686
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Background & Aims: Cycloxygenase-2 (COX-2) catalyses the rate limiting step of prostaglandin biosynthesis. Despite previous studies, it is still unclear whether COX-2 is beneficial or detrimental to cardiovascular risk. The aim of this study was to examine the -765G>C (rs20417) PTGS2 promoter gene variant, which encodes COX-2, in relation to markers of cardiovascular risk in a sample of well-characterised subjects with diabetes mellitus. Methods & Results: We observed that the CC genotype was more prevalent in Type 2 diabetes mellitus compared to Type 1 (84.2 vs 15.8%; p≤0.05), and was significantly associated with clinically manifest angina (GG vs GC vs CC: 14.3% vs 15.6% vs 28.0%; p=0.009) and lower HDL-cholesterol levels (GG vs GC vs CC: 1.3mmol/L vs 1.4mmol/L vs 1.2mmol/L; p=0.032). This is in line with previous studies showing that -765G>C genotype variant alters Sp1 binding, resulting in decreased COX-2 activity which is associated with atherosclerosis. Conclusion: We conclude that the CC genotype may contribute to a reduction of prostaglandin E2 mediated insulin secretion, predisposing those individuals to Type 2 diabetes mellitus. Further prospective work is warranted in order to examine the association between COX-2 and cardiovascular risk.
published_date 2016-12-31T04:02:13Z
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