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Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence

J. Oliveira–Santos, R. Santos, C. Moreira, S. Abreu, L. Lopes, C. Agostinis–Sobrinho, G. Stratton, J. Mota, Gareth Stratton Orcid Logo

Nutrition, Metabolism and Cardiovascular Diseases

Swansea University Author: Gareth Stratton Orcid Logo

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DOI (Published version): 10.1016/j.numecd.2019.05.052

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Background and AimsThe long-term relations between excessive adiposity in early childhood and unfavourable cardiometabolic profiles in later ages are not yet completely understood. We aimed to assess the associations between birth weight (BW) and BMI from 6 months to 6 years of age, with biomarkers...

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Published in: Nutrition, Metabolism and Cardiovascular Diseases
ISSN: 0939-4753
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa50295
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-07-18T15:52:20.6791561</datestamp><bib-version>v2</bib-version><id>50295</id><entry>2019-05-09</entry><title>Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence</title><swanseaauthors><author><sid>6d62b2ed126961bed81a94a2beba8a01</sid><ORCID>0000-0001-5618-0803</ORCID><firstname>Gareth</firstname><surname>Stratton</surname><name>Gareth Stratton</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-05-09</date><deptcode>STSC</deptcode><abstract>Background and AimsThe long-term relations between excessive adiposity in early childhood and unfavourable cardiometabolic profiles in later ages are not yet completely understood. We aimed to assess the associations between birth weight (BW) and BMI from 6 months to 6 years of age, with biomarkers indicative of low-grade inflammation, insulin resistance and lipid profiles in adolescence.Methods and ResultsRetrospective school-based study with 415 Portuguese adolescents (220 girls), mean age of 14.08&#xB1;1.6 years old. Anthropometric data from birth to 6 years old was extracted from individual child health book records. Actual weight and height were measured and BMI calculated. Participants were classified at each time point as normal weight or overweight according to WHO reference values. Biomarkers were obtained from venous blood samples. Linear regressions were used to explore the associations between the biomarkers and early life anthropometric indicators. From 2 years onwards, BMI associated positively with the inflammatory score and HOMA-IR in adolescence. Children who were overweight/obese from 2 to 6 years of age presented significantly higher inflammatory score and HOMA-IR later in adolescence. TC/HDL ratio was also positively associated with BMI from the age of 5 years onwards. The associations between BMI and cardiometabolic outcomes remained positive in adolescence, with overweight adolescents presenting a higher inflammatory score, HOMA-IR and TC/HDL than normal weight adolescents.ConclusionA high BMI from an early age was consistently associated with worse inflammatory and lipid profiles and insulin resistance in adolescence. No associations were found between BW and the same studied outcomes.</abstract><type>Journal Article</type><journal>Nutrition, Metabolism and Cardiovascular Diseases</journal><publisher/><issnPrint>0939-4753</issnPrint><keywords>Early life anthropometry, cardiometabolic biomarkers, overweight, adolescents</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-12-31</publishedDate><doi>10.1016/j.numecd.2019.05.052</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-07-18T15:52:20.6791561</lastEdited><Created>2019-05-09T11:08:02.3446740</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences</level></path><authors><author><firstname>J.</firstname><surname>Oliveira&#x2013;Santos</surname><order>1</order></author><author><firstname>R.</firstname><surname>Santos</surname><order>2</order></author><author><firstname>C.</firstname><surname>Moreira</surname><order>3</order></author><author><firstname>S.</firstname><surname>Abreu</surname><order>4</order></author><author><firstname>L.</firstname><surname>Lopes</surname><order>5</order></author><author><firstname>C.</firstname><surname>Agostinis&#x2013;Sobrinho</surname><order>6</order></author><author><firstname>G.</firstname><surname>Stratton</surname><order>7</order></author><author><firstname>J.</firstname><surname>Mota</surname><order>8</order></author><author><firstname>Gareth</firstname><surname>Stratton</surname><orcid>0000-0001-5618-0803</orcid><order>9</order></author></authors><documents><document><filename>0050295-24052019093247.pdf</filename><originalFilename>oliveira-santos2019.pdf</originalFilename><uploaded>2019-05-24T09:32:47.0500000</uploaded><type>Output</type><contentLength>700749</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2020-05-18T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2019-07-18T15:52:20.6791561 v2 50295 2019-05-09 Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence 6d62b2ed126961bed81a94a2beba8a01 0000-0001-5618-0803 Gareth Stratton Gareth Stratton true false 2019-05-09 STSC Background and AimsThe long-term relations between excessive adiposity in early childhood and unfavourable cardiometabolic profiles in later ages are not yet completely understood. We aimed to assess the associations between birth weight (BW) and BMI from 6 months to 6 years of age, with biomarkers indicative of low-grade inflammation, insulin resistance and lipid profiles in adolescence.Methods and ResultsRetrospective school-based study with 415 Portuguese adolescents (220 girls), mean age of 14.08±1.6 years old. Anthropometric data from birth to 6 years old was extracted from individual child health book records. Actual weight and height were measured and BMI calculated. Participants were classified at each time point as normal weight or overweight according to WHO reference values. Biomarkers were obtained from venous blood samples. Linear regressions were used to explore the associations between the biomarkers and early life anthropometric indicators. From 2 years onwards, BMI associated positively with the inflammatory score and HOMA-IR in adolescence. Children who were overweight/obese from 2 to 6 years of age presented significantly higher inflammatory score and HOMA-IR later in adolescence. TC/HDL ratio was also positively associated with BMI from the age of 5 years onwards. The associations between BMI and cardiometabolic outcomes remained positive in adolescence, with overweight adolescents presenting a higher inflammatory score, HOMA-IR and TC/HDL than normal weight adolescents.ConclusionA high BMI from an early age was consistently associated with worse inflammatory and lipid profiles and insulin resistance in adolescence. No associations were found between BW and the same studied outcomes. Journal Article Nutrition, Metabolism and Cardiovascular Diseases 0939-4753 Early life anthropometry, cardiometabolic biomarkers, overweight, adolescents 31 12 2019 2019-12-31 10.1016/j.numecd.2019.05.052 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2019-07-18T15:52:20.6791561 2019-05-09T11:08:02.3446740 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences J. Oliveira–Santos 1 R. Santos 2 C. Moreira 3 S. Abreu 4 L. Lopes 5 C. Agostinis–Sobrinho 6 G. Stratton 7 J. Mota 8 Gareth Stratton 0000-0001-5618-0803 9 0050295-24052019093247.pdf oliveira-santos2019.pdf 2019-05-24T09:32:47.0500000 Output 700749 application/pdf Accepted Manuscript true 2020-05-18T00:00:00.0000000 true eng
title Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence
spellingShingle Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence
Gareth Stratton
title_short Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence
title_full Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence
title_fullStr Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence
title_full_unstemmed Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence
title_sort Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence
author_id_str_mv 6d62b2ed126961bed81a94a2beba8a01
author_id_fullname_str_mv 6d62b2ed126961bed81a94a2beba8a01_***_Gareth Stratton
author Gareth Stratton
author2 J. Oliveira–Santos
R. Santos
C. Moreira
S. Abreu
L. Lopes
C. Agostinis–Sobrinho
G. Stratton
J. Mota
Gareth Stratton
format Journal article
container_title Nutrition, Metabolism and Cardiovascular Diseases
publishDate 2019
institution Swansea University
issn 0939-4753
doi_str_mv 10.1016/j.numecd.2019.05.052
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
active_str 0
description Background and AimsThe long-term relations between excessive adiposity in early childhood and unfavourable cardiometabolic profiles in later ages are not yet completely understood. We aimed to assess the associations between birth weight (BW) and BMI from 6 months to 6 years of age, with biomarkers indicative of low-grade inflammation, insulin resistance and lipid profiles in adolescence.Methods and ResultsRetrospective school-based study with 415 Portuguese adolescents (220 girls), mean age of 14.08±1.6 years old. Anthropometric data from birth to 6 years old was extracted from individual child health book records. Actual weight and height were measured and BMI calculated. Participants were classified at each time point as normal weight or overweight according to WHO reference values. Biomarkers were obtained from venous blood samples. Linear regressions were used to explore the associations between the biomarkers and early life anthropometric indicators. From 2 years onwards, BMI associated positively with the inflammatory score and HOMA-IR in adolescence. Children who were overweight/obese from 2 to 6 years of age presented significantly higher inflammatory score and HOMA-IR later in adolescence. TC/HDL ratio was also positively associated with BMI from the age of 5 years onwards. The associations between BMI and cardiometabolic outcomes remained positive in adolescence, with overweight adolescents presenting a higher inflammatory score, HOMA-IR and TC/HDL than normal weight adolescents.ConclusionA high BMI from an early age was consistently associated with worse inflammatory and lipid profiles and insulin resistance in adolescence. No associations were found between BW and the same studied outcomes.
published_date 2019-12-31T04:01:42Z
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score 11.037603

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