No Cover Image

Journal article 695 views

Digit ratio (2D:4D), myocardial infarction and fibrinogen in men

J.T. Manning, P.E. Bundred, A. Kasielska-Trojan, T. Smith-Straney, L. Mason

Early Human Development, Volume: 133, Pages: 18 - 22

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1016/j.earlhumdev.2019.04.008

Abstract

Background: Digit ratio (2D:4D: a correlate of prenatal testosterone and oestrogen) is sexually dimorphic withmales<females. High 2D:4D may be associated with early myocardial infarction (MI). Fibrinogen shows sexdifferences (males>females) and is associated with coronary heart disease (CHD),...

Full description

Published in: Early Human Development
ISSN: 03783782
Published: 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa50121
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2019-05-09T20:00:55Z
last_indexed 2019-05-09T20:00:55Z
id cronfa50121
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-04-30T11:31:06Z</datestamp><bib-version>v2</bib-version><id>50121</id><entry>2019-04-30</entry><title>Digit ratio (2D:4D), myocardial infarction and fibrinogen in men</title><alternativeTitle></alternativeTitle><author>Laura Mason</author><firstname>Laura</firstname><surname>Mason</surname><active>true</active><ORCID>0000-0002-9679-7063</ORCID><ethesisStudent>false</ethesisStudent><sid>ef88a9ba99af7706e3e80e418f482e0a</sid><email>23516ad864c1ff02428e6b5553634518</email><emailaddr>qlqKQ8vMYl+FLzlNzxll/oJSbZF11mHm1K8NtCGVMYw=</emailaddr><date>2019-04-30</date><deptcode>STSC</deptcode><abstract>Background: Digit ratio (2D:4D: a correlate of prenatal testosterone and oestrogen) is sexually dimorphic withmales&lt;females. High 2D:4D may be associated with early myocardial infarction (MI). Fibrinogen shows sexdifferences (males&gt;females) and is associated with coronary heart disease (CHD), the incidence of which is also sexdependent (males&gt;females). Aims: We considered the relationship between 2D:4D, levels of fibrinogen and age at MI.Study design: Digit lengths, height, weight, smoking history and Townsend scores were recorded. Levels of fibrinogenwere measured for 150 patients and 140 age-matched controls. Subjects: The sample consisted of 441 men (301patients who had experienced an MI, 140 controls). Results: Right 2D:4D was positively correlated with fibrinogen inthe controls as was right and left 2D:4D in the total sample. Multiple regression analysis showed right and left 2D:4Dwere positively correlated with fibrinogen in the total sample independent of MI status, age, BMI, smoking history andTownsend scores. Right 2D:4D and right-left 2D:4D (Dr-l) were negatively correlated with age at MI, independent ofBMI, smoking history, and Townsend scores. The MI and control groups did not differ in their 2D:4D. Conclusion: Menwith low 2D:4D tend to have low levels of fibrinogen independent of MI, age, BMI, smoking habits and socioeconomicstatus. Right 2D:4D and Dr-l were negatively related to age at MI but there were no differences in 2D:4D between theMI and control groups. We discuss the implications of our findings for relationships between 2D:4D, MI andperformance in endurance sports in men.</abstract><type>Journal article</type><journal>Early Human Development</journal><volume>133</volume><journalNumber></journalNumber><paginationStart>18</paginationStart><paginationEnd>22</paginationEnd><publisher></publisher><placeOfPublication></placeOfPublication><isbnPrint></isbnPrint><isbnElectronic></isbnElectronic><issnPrint>03783782</issnPrint><issnElectronic></issnElectronic><keywords>Digit ratio; 2D:4D; Myocardial infarction; Fibrinogen</keywords><publishedDay>27</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-04-27</publishedDate><doi>10.1016/j.earlhumdev.2019.04.008</doi><url></url><notes></notes><college>College of Engineering</college><department>Sports Science</department><CollegeCode>CENG</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution/><researchGroup>Applied Sports Technology Exercise and Medicine Research Centre</researchGroup><supervisor></supervisor><sponsorsfunders/><grantnumber/><degreelevel/><degreename>None</degreename><lastEdited>2019-04-30T11:31:06Z</lastEdited><Created>2019-04-30T11:31:06Z</Created><path><level id="1">College of Engineering</level><level id="2">Sports Science</level></path><authors><author><firstname>J.T.</firstname><surname>Manning</surname><orcid/><order>1</order></author><author><firstname>P.E.</firstname><surname>Bundred</surname><orcid/><order>2</order></author><author><firstname>A.</firstname><surname>Kasielska-Trojan</surname><orcid/><order>3</order></author><author><firstname>T.</firstname><surname>Smith-Straney</surname><orcid/><order>4</order></author><author><firstname>L.</firstname><surname>Mason</surname><orcid/><order>5</order></author></authors><documents/></rfc1807>
spelling 2019-04-30T11:31:06Z v2 50121 2019-04-30 Digit ratio (2D:4D), myocardial infarction and fibrinogen in men Laura Mason Laura Mason true 0000-0002-9679-7063 false ef88a9ba99af7706e3e80e418f482e0a 23516ad864c1ff02428e6b5553634518 qlqKQ8vMYl+FLzlNzxll/oJSbZF11mHm1K8NtCGVMYw= 2019-04-30 STSC Background: Digit ratio (2D:4D: a correlate of prenatal testosterone and oestrogen) is sexually dimorphic withmales<females. High 2D:4D may be associated with early myocardial infarction (MI). Fibrinogen shows sexdifferences (males>females) and is associated with coronary heart disease (CHD), the incidence of which is also sexdependent (males>females). Aims: We considered the relationship between 2D:4D, levels of fibrinogen and age at MI.Study design: Digit lengths, height, weight, smoking history and Townsend scores were recorded. Levels of fibrinogenwere measured for 150 patients and 140 age-matched controls. Subjects: The sample consisted of 441 men (301patients who had experienced an MI, 140 controls). Results: Right 2D:4D was positively correlated with fibrinogen inthe controls as was right and left 2D:4D in the total sample. Multiple regression analysis showed right and left 2D:4Dwere positively correlated with fibrinogen in the total sample independent of MI status, age, BMI, smoking history andTownsend scores. Right 2D:4D and right-left 2D:4D (Dr-l) were negatively correlated with age at MI, independent ofBMI, smoking history, and Townsend scores. The MI and control groups did not differ in their 2D:4D. Conclusion: Menwith low 2D:4D tend to have low levels of fibrinogen independent of MI, age, BMI, smoking habits and socioeconomicstatus. Right 2D:4D and Dr-l were negatively related to age at MI but there were no differences in 2D:4D between theMI and control groups. We discuss the implications of our findings for relationships between 2D:4D, MI andperformance in endurance sports in men. Journal article Early Human Development 133 18 22 03783782 Digit ratio; 2D:4D; Myocardial infarction; Fibrinogen 27 4 2019 2019-04-27 10.1016/j.earlhumdev.2019.04.008 College of Engineering Sports Science CENG STSC Applied Sports Technology Exercise and Medicine Research Centre None 2019-04-30T11:31:06Z 2019-04-30T11:31:06Z College of Engineering Sports Science J.T. Manning 1 P.E. Bundred 2 A. Kasielska-Trojan 3 T. Smith-Straney 4 L. Mason 5
title Digit ratio (2D:4D), myocardial infarction and fibrinogen in men
spellingShingle Digit ratio (2D:4D), myocardial infarction and fibrinogen in men
Mason, Laura
title_short Digit ratio (2D:4D), myocardial infarction and fibrinogen in men
title_full Digit ratio (2D:4D), myocardial infarction and fibrinogen in men
title_fullStr Digit ratio (2D:4D), myocardial infarction and fibrinogen in men
title_full_unstemmed Digit ratio (2D:4D), myocardial infarction and fibrinogen in men
title_sort Digit ratio (2D:4D), myocardial infarction and fibrinogen in men
author_id_str_mv ef88a9ba99af7706e3e80e418f482e0a
author_id_fullname_str_mv ef88a9ba99af7706e3e80e418f482e0a_***_Mason, Laura
author Mason, Laura
author2 J.T. Manning
P.E. Bundred
A. Kasielska-Trojan
T. Smith-Straney
L. Mason
format Journal article
container_title Early Human Development
container_volume 133
container_start_page 18
publishDate 2019
institution Swansea University
issn 03783782
doi_str_mv 10.1016/j.earlhumdev.2019.04.008
college_str College of Engineering
hierarchytype
hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Sports Science{{{_:::_}}}College of Engineering{{{_:::_}}}Sports Science
document_store_str 0
active_str 1
researchgroup_str Applied Sports Technology Exercise and Medicine Research Centre
description Background: Digit ratio (2D:4D: a correlate of prenatal testosterone and oestrogen) is sexually dimorphic withmales<females. High 2D:4D may be associated with early myocardial infarction (MI). Fibrinogen shows sexdifferences (males>females) and is associated with coronary heart disease (CHD), the incidence of which is also sexdependent (males>females). Aims: We considered the relationship between 2D:4D, levels of fibrinogen and age at MI.Study design: Digit lengths, height, weight, smoking history and Townsend scores were recorded. Levels of fibrinogenwere measured for 150 patients and 140 age-matched controls. Subjects: The sample consisted of 441 men (301patients who had experienced an MI, 140 controls). Results: Right 2D:4D was positively correlated with fibrinogen inthe controls as was right and left 2D:4D in the total sample. Multiple regression analysis showed right and left 2D:4Dwere positively correlated with fibrinogen in the total sample independent of MI status, age, BMI, smoking history andTownsend scores. Right 2D:4D and right-left 2D:4D (Dr-l) were negatively correlated with age at MI, independent ofBMI, smoking history, and Townsend scores. The MI and control groups did not differ in their 2D:4D. Conclusion: Menwith low 2D:4D tend to have low levels of fibrinogen independent of MI, age, BMI, smoking habits and socioeconomicstatus. Right 2D:4D and Dr-l were negatively related to age at MI but there were no differences in 2D:4D between theMI and control groups. We discuss the implications of our findings for relationships between 2D:4D, MI andperformance in endurance sports in men.
published_date 2019-04-27T11:25:55Z
_version_ 1633412087550050304
score 11.037603

Similar Items