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Soft Robotic Surrogate Lung

Olivier Ranunkel, Firat Güder, Hari Arora Orcid Logo

ACS Applied Bio Materials, Volume: 2, Issue: 4, Pages: 1490 - 1497

Swansea University Author: Hari Arora Orcid Logo

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DOI (Published version): 10.1021/acsabm.8b00753

Abstract

Previous artificial lung surrogates used hydrogels or balloon-like inflatable structures without reproducing the alveolar network or breathing action within the lung. A physiologically accurate, air-filled lung model inspired by soft robotics is presented. The model, soft robotic surrogate lung (SRS...

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Published in: ACS Applied Bio Materials
ISSN: 2576-6422 2576-6422
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa49216
first_indexed 2019-03-18T13:59:30Z
last_indexed 2023-02-15T03:57:28Z
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spelling 2023-02-14T16:41:58.2589369 v2 49216 2019-03-18 Soft Robotic Surrogate Lung ed7371c768e9746008a6807f9f7a1555 0000-0002-9790-0907 Hari Arora Hari Arora true false 2019-03-18 EAAS Previous artificial lung surrogates used hydrogels or balloon-like inflatable structures without reproducing the alveolar network or breathing action within the lung. A physiologically accurate, air-filled lung model inspired by soft robotics is presented. The model, soft robotic surrogate lung (SRSL), is composed of clusters of artificial alveoli made of platinum-cured silicone, with internal pathways for air flow. Mechanical tests in conjunction with full-field image and volume correlation techniques characterize the SRSL behavior. SRSLs enable both healthy and pathological lungs to be studied in idealized cases. Although simple in construction, the connected airways demonstrate clearly the importance of an inflatable network for capturing basic lung behavior (compared to more simplified lung surrogates). The SRSL highlights the potentially damaging nature of local defects caused by occlusion or overdistension (present in conditions such as chronic obstructive pulmonary disease). The SRSL is developed as a potential upgrade to conventional surrogates used for injury risk predictions in trauma. The deformation of the SRSL is evaluated against blast trauma using a shock tube. The SRSL was compared to other conventional trauma surrogate materials and showed greatest similarity to lung tissue. The SRSL has the potential to complement conventional biomechanical studies and reduce animal use in basic biomechanics studies, where high severity protocols are used. Journal Article ACS Applied Bio Materials 2 4 1490 1497 2576-6422 2576-6422 biomechanics; image correlation; lung; soft robotics; trauma 15 4 2019 2019-04-15 10.1021/acsabm.8b00753 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2023-02-14T16:41:58.2589369 2019-03-18T09:58:54.9213667 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Olivier Ranunkel 1 Firat Güder 2 Hari Arora 0000-0002-9790-0907 3 49216__17783__e1c79b918df24708938818b6e91c40b8.pdf 49216.pdf 2020-07-24T11:56:03.0914104 Output 6327443 application/pdf Version of Record true Released under the terms of a Creative Commons Attribution License (CC-BY). true eng http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html
title Soft Robotic Surrogate Lung
spellingShingle Soft Robotic Surrogate Lung
Hari Arora
title_short Soft Robotic Surrogate Lung
title_full Soft Robotic Surrogate Lung
title_fullStr Soft Robotic Surrogate Lung
title_full_unstemmed Soft Robotic Surrogate Lung
title_sort Soft Robotic Surrogate Lung
author_id_str_mv ed7371c768e9746008a6807f9f7a1555
author_id_fullname_str_mv ed7371c768e9746008a6807f9f7a1555_***_Hari Arora
author Hari Arora
author2 Olivier Ranunkel
Firat Güder
Hari Arora
format Journal article
container_title ACS Applied Bio Materials
container_volume 2
container_issue 4
container_start_page 1490
publishDate 2019
institution Swansea University
issn 2576-6422
2576-6422
doi_str_mv 10.1021/acsabm.8b00753
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description Previous artificial lung surrogates used hydrogels or balloon-like inflatable structures without reproducing the alveolar network or breathing action within the lung. A physiologically accurate, air-filled lung model inspired by soft robotics is presented. The model, soft robotic surrogate lung (SRSL), is composed of clusters of artificial alveoli made of platinum-cured silicone, with internal pathways for air flow. Mechanical tests in conjunction with full-field image and volume correlation techniques characterize the SRSL behavior. SRSLs enable both healthy and pathological lungs to be studied in idealized cases. Although simple in construction, the connected airways demonstrate clearly the importance of an inflatable network for capturing basic lung behavior (compared to more simplified lung surrogates). The SRSL highlights the potentially damaging nature of local defects caused by occlusion or overdistension (present in conditions such as chronic obstructive pulmonary disease). The SRSL is developed as a potential upgrade to conventional surrogates used for injury risk predictions in trauma. The deformation of the SRSL is evaluated against blast trauma using a shock tube. The SRSL was compared to other conventional trauma surrogate materials and showed greatest similarity to lung tissue. The SRSL has the potential to complement conventional biomechanical studies and reduce animal use in basic biomechanics studies, where high severity protocols are used.
published_date 2019-04-15T19:40:54Z
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