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Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors

Nuno F. Santos, Sónia O. Pereira, António J. S. Fernandes, Thiago L. Vasconcelos, Chung M. Fung, Bráulio S. Archanjo, Carlos A. Achete, Sofia R. Teixeira, Rui F. Silva, Florinda M. Costa, Sofia Rodrigues Teixeira

ACS Applied Materials & Interfaces, Volume: 11, Issue: 8, Pages: 8470 - 8482

Swansea University Author: Sofia Rodrigues Teixeira

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DOI (Published version): 10.1021/acsami.9b00352

Abstract

Hybrid diamond–graphite nanoplatelet (DGNP) thin films are produced and applied to label-free impedimetric biosensors for the first time, using avidin detection as a proof of concept. The DGNPs are synthesized by microwave plasma chemical vapor deposition through H2/CH4/N2 gas mixtures in a reproduc...

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Published in: ACS Applied Materials & Interfaces
ISSN: 1944-8244 1944-8252
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa49103
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spelling 2019-05-13T13:51:23.8887848 v2 49103 2019-03-04 Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors cdbc4e7462ad09634638f5b3d7ecf2d3 Sofia Rodrigues Teixeira Sofia Rodrigues Teixeira true false 2019-03-04 PMSC Hybrid diamond–graphite nanoplatelet (DGNP) thin films are produced and applied to label-free impedimetric biosensors for the first time, using avidin detection as a proof of concept. The DGNPs are synthesized by microwave plasma chemical vapor deposition through H2/CH4/N2 gas mixtures in a reproducible and rapid single-step process. The material building unit consists of an inner two-dimensional-like nanodiamond with preferential vertical alignment covered by and covalently bound to nanocrystalline graphite grains, exhibiting {111}diamond||{0002}graphite epitaxy. The DGNP films’ morphostructural aspects are of interest for electrochemical transduction, in general, and for Faradaic impedimetric biosensors, in particular, combining enhanced surface area for biorecognition element loading and facile Faradaic charge transfer. Charge transfer rate constants in phosphate buffer saline/[Fe(CN)6]4– solution are shown to increase up to 5.6 × 10–3 cm s–1 upon N2 addition to DGNP synthesis. For the impedimetric detection of avidin, biotin molecules are covalently bound as avidin specific recognition elements on (3-aminopropyl)triethoxysilane-functionalized DGNP surfaces. Avidin quantification is attained within the 10–1000 μg mL–1 range following a logarithmic dependency. The limits of detection and of quantitation are 1.3 and 6.4 μg mL–1 (19 and 93 nM), respectively, and 2.3 and 13.8 μg mL–1 (33 and 200 nM) when considering the nonspecific response of the sensors. Journal Article ACS Applied Materials & Interfaces 11 8 8470 8482 1944-8244 1944-8252 biosensors; charge transfer; impedimetry; label-free; nanodiamond; nanographite 31 12 2019 2019-12-31 10.1021/acsami.9b00352 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2019-05-13T13:51:23.8887848 2019-03-04T10:05:05.0716517 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Nuno F. Santos 1 Sónia O. Pereira 2 António J. S. Fernandes 3 Thiago L. Vasconcelos 4 Chung M. Fung 5 Bráulio S. Archanjo 6 Carlos A. Achete 7 Sofia R. Teixeira 8 Rui F. Silva 9 Florinda M. Costa 10 Sofia Rodrigues Teixeira 11
title Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors
spellingShingle Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors
Sofia Rodrigues Teixeira
title_short Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors
title_full Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors
title_fullStr Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors
title_full_unstemmed Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors
title_sort Physical Structure and Electrochemical Response of Diamond–Graphite Nanoplatelets: From CVD Synthesis to Label-Free Biosensors
author_id_str_mv cdbc4e7462ad09634638f5b3d7ecf2d3
author_id_fullname_str_mv cdbc4e7462ad09634638f5b3d7ecf2d3_***_Sofia Rodrigues Teixeira
author Sofia Rodrigues Teixeira
author2 Nuno F. Santos
Sónia O. Pereira
António J. S. Fernandes
Thiago L. Vasconcelos
Chung M. Fung
Bráulio S. Archanjo
Carlos A. Achete
Sofia R. Teixeira
Rui F. Silva
Florinda M. Costa
Sofia Rodrigues Teixeira
format Journal article
container_title ACS Applied Materials & Interfaces
container_volume 11
container_issue 8
container_start_page 8470
publishDate 2019
institution Swansea University
issn 1944-8244
1944-8252
doi_str_mv 10.1021/acsami.9b00352
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 0
active_str 0
description Hybrid diamond–graphite nanoplatelet (DGNP) thin films are produced and applied to label-free impedimetric biosensors for the first time, using avidin detection as a proof of concept. The DGNPs are synthesized by microwave plasma chemical vapor deposition through H2/CH4/N2 gas mixtures in a reproducible and rapid single-step process. The material building unit consists of an inner two-dimensional-like nanodiamond with preferential vertical alignment covered by and covalently bound to nanocrystalline graphite grains, exhibiting {111}diamond||{0002}graphite epitaxy. The DGNP films’ morphostructural aspects are of interest for electrochemical transduction, in general, and for Faradaic impedimetric biosensors, in particular, combining enhanced surface area for biorecognition element loading and facile Faradaic charge transfer. Charge transfer rate constants in phosphate buffer saline/[Fe(CN)6]4– solution are shown to increase up to 5.6 × 10–3 cm s–1 upon N2 addition to DGNP synthesis. For the impedimetric detection of avidin, biotin molecules are covalently bound as avidin specific recognition elements on (3-aminopropyl)triethoxysilane-functionalized DGNP surfaces. Avidin quantification is attained within the 10–1000 μg mL–1 range following a logarithmic dependency. The limits of detection and of quantitation are 1.3 and 6.4 μg mL–1 (19 and 93 nM), respectively, and 2.3 and 13.8 μg mL–1 (33 and 200 nM) when considering the nonspecific response of the sensors.
published_date 2019-12-31T03:59:53Z
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score 11.013171

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