No Cover Image

Conference Paper/Proceeding/Abstract 880 views

Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach

A. S. Ademiloye, K. M. Liew, L. W. Zhang, Adesola Ademiloye Orcid Logo

2016 International Conference on Biomedical Engineering (BME-HUST)

Swansea University Author: Adesola Ademiloye Orcid Logo

Full text not available from this repository: check for access using links below.

DOI (Published version): 10.1109/BME-HUST.2016.7782101

Abstract

With the rapid increase in the number of deaths worldwide due to blood related diseases such as malaria, sickle cell anemia and other types of anemias, the importance of more insightful studies on healthy red blood cell (RBC) membrane cannot be overemphasized since the development and progression of...

Full description

Published in: 2016 International Conference on Biomedical Engineering (BME-HUST)
ISBN: 978-1-5090-1097-4 978-1-5090-1099-8
Published: Hanoi, Vietnam 2016 International Conference on Biomedical Engineering (BME-HUST) 2016
URI: https://cronfa.swan.ac.uk/Record/cronfa44914
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2018-10-16T13:47:49Z
last_indexed 2018-11-12T20:22:11Z
id cronfa44914
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2018-11-12T14:54:20.0724520</datestamp><bib-version>v2</bib-version><id>44914</id><entry>2018-10-16</entry><title>Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach</title><swanseaauthors><author><sid>e37960ed89a7e3eaeba2201762626594</sid><ORCID>0000-0002-9741-6488</ORCID><firstname>Adesola</firstname><surname>Ademiloye</surname><name>Adesola Ademiloye</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-10-16</date><deptcode>MEDE</deptcode><abstract>With the rapid increase in the number of deaths worldwide due to blood related diseases such as malaria, sickle cell anemia and other types of anemias, the importance of more insightful studies on healthy red blood cell (RBC) membrane cannot be overemphasized since the development and progression of these infectious diseases are closely related to the state of the membrane. Furthermore, due to the recent increase in life-shortening terminal diseases leading to organ failure, the use and design of artificial organs must be enhanced and improved through a better understanding of the RBC membrane biomechanical properties to prevent hemolysis. In this paper, we modeled the biomechanical responses of healthy red blood cell (RBC) membrane under axial, shearing and area dilating loading conditions using a three-dimensional (3D) quasicontinuum approach. Here, the atomic scale strain energy density of the RBC membrane, computed using a representative unit cell of the spectrin cytoskeleton, is introduced into the continuum-scale for numerical simulation using the standard Cauchy-Born rule. Results obtained from this study confirm that the RBC membrane exhibit strong strain-stiffening behavior that is highly sensitive to microstructural changes as shown in its stress-strain relationship curves. We conclude that the RBC membrane can only sustain large strains up to a certain limit beyond which hemolysis may occur, hence strains and pumping forces in artificial blood-pumping devices must be precisely regulated.</abstract><type>Conference Paper/Proceeding/Abstract</type><journal>2016 International Conference on Biomedical Engineering (BME-HUST)</journal><publisher>2016 International Conference on Biomedical Engineering (BME-HUST)</publisher><placeOfPublication>Hanoi, Vietnam</placeOfPublication><isbnPrint>978-1-5090-1097-4</isbnPrint><isbnElectronic>978-1-5090-1099-8</isbnElectronic><keywords/><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2016</publishedYear><publishedDate>2016-12-31</publishedDate><doi>10.1109/BME-HUST.2016.7782101</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2018-11-12T14:54:20.0724520</lastEdited><Created>2018-10-16T12:47:53.7477340</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>A. S.</firstname><surname>Ademiloye</surname><order>1</order></author><author><firstname>K. M.</firstname><surname>Liew</surname><order>2</order></author><author><firstname>L. W.</firstname><surname>Zhang</surname><order>3</order></author><author><firstname>Adesola</firstname><surname>Ademiloye</surname><orcid>0000-0002-9741-6488</orcid><order>4</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2018-11-12T14:54:20.0724520 v2 44914 2018-10-16 Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE With the rapid increase in the number of deaths worldwide due to blood related diseases such as malaria, sickle cell anemia and other types of anemias, the importance of more insightful studies on healthy red blood cell (RBC) membrane cannot be overemphasized since the development and progression of these infectious diseases are closely related to the state of the membrane. Furthermore, due to the recent increase in life-shortening terminal diseases leading to organ failure, the use and design of artificial organs must be enhanced and improved through a better understanding of the RBC membrane biomechanical properties to prevent hemolysis. In this paper, we modeled the biomechanical responses of healthy red blood cell (RBC) membrane under axial, shearing and area dilating loading conditions using a three-dimensional (3D) quasicontinuum approach. Here, the atomic scale strain energy density of the RBC membrane, computed using a representative unit cell of the spectrin cytoskeleton, is introduced into the continuum-scale for numerical simulation using the standard Cauchy-Born rule. Results obtained from this study confirm that the RBC membrane exhibit strong strain-stiffening behavior that is highly sensitive to microstructural changes as shown in its stress-strain relationship curves. We conclude that the RBC membrane can only sustain large strains up to a certain limit beyond which hemolysis may occur, hence strains and pumping forces in artificial blood-pumping devices must be precisely regulated. Conference Paper/Proceeding/Abstract 2016 International Conference on Biomedical Engineering (BME-HUST) 2016 International Conference on Biomedical Engineering (BME-HUST) Hanoi, Vietnam 978-1-5090-1097-4 978-1-5090-1099-8 31 12 2016 2016-12-31 10.1109/BME-HUST.2016.7782101 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2018-11-12T14:54:20.0724520 2018-10-16T12:47:53.7477340 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering A. S. Ademiloye 1 K. M. Liew 2 L. W. Zhang 3 Adesola Ademiloye 0000-0002-9741-6488 4
title Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach
spellingShingle Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach
Adesola Ademiloye
title_short Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach
title_full Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach
title_fullStr Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach
title_full_unstemmed Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach
title_sort Numerical modeling of biomechanical responses of healthy red blood cell membrane under various loading conditions using a 3D quasicontinuum approach
author_id_str_mv e37960ed89a7e3eaeba2201762626594
author_id_fullname_str_mv e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
author Adesola Ademiloye
author2 A. S. Ademiloye
K. M. Liew
L. W. Zhang
Adesola Ademiloye
format Conference Paper/Proceeding/Abstract
container_title 2016 International Conference on Biomedical Engineering (BME-HUST)
publishDate 2016
institution Swansea University
isbn 978-1-5090-1097-4
978-1-5090-1099-8
doi_str_mv 10.1109/BME-HUST.2016.7782101
publisher 2016 International Conference on Biomedical Engineering (BME-HUST)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description With the rapid increase in the number of deaths worldwide due to blood related diseases such as malaria, sickle cell anemia and other types of anemias, the importance of more insightful studies on healthy red blood cell (RBC) membrane cannot be overemphasized since the development and progression of these infectious diseases are closely related to the state of the membrane. Furthermore, due to the recent increase in life-shortening terminal diseases leading to organ failure, the use and design of artificial organs must be enhanced and improved through a better understanding of the RBC membrane biomechanical properties to prevent hemolysis. In this paper, we modeled the biomechanical responses of healthy red blood cell (RBC) membrane under axial, shearing and area dilating loading conditions using a three-dimensional (3D) quasicontinuum approach. Here, the atomic scale strain energy density of the RBC membrane, computed using a representative unit cell of the spectrin cytoskeleton, is introduced into the continuum-scale for numerical simulation using the standard Cauchy-Born rule. Results obtained from this study confirm that the RBC membrane exhibit strong strain-stiffening behavior that is highly sensitive to microstructural changes as shown in its stress-strain relationship curves. We conclude that the RBC membrane can only sustain large strains up to a certain limit beyond which hemolysis may occur, hence strains and pumping forces in artificial blood-pumping devices must be precisely regulated.
published_date 2016-12-31T03:56:24Z
_version_ 1763752840577155072
score 11.037056

Similar Items