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Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach

Adesola Ademiloye Orcid Logo, L.W. Zhang, K.M. Liew

Proceedings of the International MultiConference of Engineers and Computer Scientists 2016, Pages: 942 - 946

Swansea University Author: Adesola Ademiloye Orcid Logo

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DOI (Published version): 10.13140/RG.2.1.3088.8082

Abstract

This paper employs the gradient theory to study the elastic properties and deformability of red blood cell (RBC) membrane using the first-order Cauchy-Born rule as an atomistic-continuum hyperelastic constitutive model that directly incorporates the microstructure of the spectrin network. The well-k...

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Published in: Proceedings of the International MultiConference of Engineers and Computer Scientists 2016
ISBN: 978-988-14047-6-3
ISSN: 2078-0958 2078-0966
Published: Hong Kong International MultiConference of Engineers and Computer Scientists 2016 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa44912
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first_indexed 2018-10-16T13:47:49Z
last_indexed 2019-01-14T13:58:37Z
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spelling 2019-01-14T11:48:37.2249224 v2 44912 2018-10-16 Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE This paper employs the gradient theory to study the elastic properties and deformability of red blood cell (RBC) membrane using the first-order Cauchy-Born rule as an atomistic-continuum hyperelastic constitutive model that directly incorporates the microstructure of the spectrin network. The well-known Cauchy-Born rule is extended to account for a three-dimensional (3D) reference configuration. Using the strain energy density function and the deformation gradient tensor, the elastic properties of the RBC membrane were predicted by minimizing the potential energy in the representative cell. This extended formulation was then coupled with the meshfree method for numerical modeling of the finite deformation of the RBC membrane by simulating the optical tweezer experiment using a self-written MATLAB code. The results obtained provide new insight into the elastic properties and deformability of RBC membrane. In addition, the proposed method performs better when compared with those found in literature in terms of prediction accuracy and computation efficiency. Conference Paper/Proceeding/Abstract Proceedings of the International MultiConference of Engineers and Computer Scientists 2016 942 946 International MultiConference of Engineers and Computer Scientists 2016 Hong Kong 978-988-14047-6-3 2078-0958 2078-0966 31 3 2016 2016-03-31 10.13140/RG.2.1.3088.8082 http://www.iaeng.org/publication/IMECS2016/IMECS2016_pp947-952.pdf COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2019-01-14T11:48:37.2249224 2018-10-16T12:47:51.7948573 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Adesola Ademiloye 0000-0002-9741-6488 1 L.W. Zhang 2 K.M. Liew 3 0044912-12112018150606.pdf ademiloye2016(2).pdf 2018-11-12T15:06:06.8500000 Output 1311208 application/pdf Version of Record true 2018-11-12T00:00:00.0000000 true eng
title Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach
spellingShingle Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach
Adesola Ademiloye
title_short Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach
title_full Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach
title_fullStr Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach
title_full_unstemmed Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach
title_sort Predicting the elastic properties and deformability of red blood cell membrane using an atomistic-continuum approach
author_id_str_mv e37960ed89a7e3eaeba2201762626594
author_id_fullname_str_mv e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
author Adesola Ademiloye
author2 Adesola Ademiloye
L.W. Zhang
K.M. Liew
format Conference Paper/Proceeding/Abstract
container_title Proceedings of the International MultiConference of Engineers and Computer Scientists 2016
container_start_page 942
publishDate 2016
institution Swansea University
isbn 978-988-14047-6-3
issn 2078-0958
2078-0966
doi_str_mv 10.13140/RG.2.1.3088.8082
publisher International MultiConference of Engineers and Computer Scientists 2016
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
url http://www.iaeng.org/publication/IMECS2016/IMECS2016_pp947-952.pdf
document_store_str 1
active_str 0
description This paper employs the gradient theory to study the elastic properties and deformability of red blood cell (RBC) membrane using the first-order Cauchy-Born rule as an atomistic-continuum hyperelastic constitutive model that directly incorporates the microstructure of the spectrin network. The well-known Cauchy-Born rule is extended to account for a three-dimensional (3D) reference configuration. Using the strain energy density function and the deformation gradient tensor, the elastic properties of the RBC membrane were predicted by minimizing the potential energy in the representative cell. This extended formulation was then coupled with the meshfree method for numerical modeling of the finite deformation of the RBC membrane by simulating the optical tweezer experiment using a self-written MATLAB code. The results obtained provide new insight into the elastic properties and deformability of RBC membrane. In addition, the proposed method performs better when compared with those found in literature in terms of prediction accuracy and computation efficiency.
published_date 2016-03-31T03:56:24Z
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score 11.037056

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