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A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane

Adesola Ademiloye Orcid Logo, L.W. Zhang, K.M. Liew

Applied Mathematical Modelling, Volume: 49, Pages: 35 - 47

Swansea University Author: Adesola Ademiloye Orcid Logo

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DOI (Published version): 10.1016/j.apm.2017.04.030

Abstract

This paper presents the first attempt to comprehensively estimate the elastic properties and mechanical responses of malaria-infected red blood cell (iRBC) membrane when subjected to uniaxial, shear and isotropic area-dilation loading conditions. With the three-dimensional (3D) quasicontinuum approa...

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Published in: Applied Mathematical Modelling
ISSN: 0307-904X
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa44906
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spelling 2021-01-14T12:48:49.2285447 v2 44906 2018-10-16 A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE This paper presents the first attempt to comprehensively estimate the elastic properties and mechanical responses of malaria-infected red blood cell (iRBC) membrane when subjected to uniaxial, shear and isotropic area-dilation loading conditions. With the three-dimensional (3D) quasicontinuum approach, we predicted the biomechanical properties of the iRBC membrane for all infection stages. Effect of temperature on the membrane elastic properties during the trophozoite stage was also examined. It is found that a multifold increase in the elastic properties of the iRBC membrane occurs as infection progresses. The axial, shear and area stiffnesses of the iRBC membrane increase exponentially, resulting in semi-logarithmic stress–strain relationship curves. In addition, the rigidity of the iRBC membrane in the trophozoite stage increases as temperature rise. It is concluded that Plasmodium falciparum parasites significantly affect the biomechanical properties of the RBC membrane due to the structural remodeling of the iRBC membrane microstructure. Journal Article Applied Mathematical Modelling 49 35 47 0307-904X Plasmodium falciparum, Multiscale Cauchy–Born modeling, RBC membrane microstructure, Elastomechanical properties, Stress–strain curves, Temperature effect 1 9 2017 2017-09-01 10.1016/j.apm.2017.04.030 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2021-01-14T12:48:49.2285447 2018-10-16T12:47:44.3472343 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Adesola Ademiloye 0000-0002-9741-6488 1 L.W. Zhang 2 K.M. Liew 3
title A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane
spellingShingle A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane
Adesola Ademiloye
title_short A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane
title_full A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane
title_fullStr A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane
title_full_unstemmed A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane
title_sort A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane
author_id_str_mv e37960ed89a7e3eaeba2201762626594
author_id_fullname_str_mv e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
author Adesola Ademiloye
author2 Adesola Ademiloye
L.W. Zhang
K.M. Liew
format Journal article
container_title Applied Mathematical Modelling
container_volume 49
container_start_page 35
publishDate 2017
institution Swansea University
issn 0307-904X
doi_str_mv 10.1016/j.apm.2017.04.030
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description This paper presents the first attempt to comprehensively estimate the elastic properties and mechanical responses of malaria-infected red blood cell (iRBC) membrane when subjected to uniaxial, shear and isotropic area-dilation loading conditions. With the three-dimensional (3D) quasicontinuum approach, we predicted the biomechanical properties of the iRBC membrane for all infection stages. Effect of temperature on the membrane elastic properties during the trophozoite stage was also examined. It is found that a multifold increase in the elastic properties of the iRBC membrane occurs as infection progresses. The axial, shear and area stiffnesses of the iRBC membrane increase exponentially, resulting in semi-logarithmic stress–strain relationship curves. In addition, the rigidity of the iRBC membrane in the trophozoite stage increases as temperature rise. It is concluded that Plasmodium falciparum parasites significantly affect the biomechanical properties of the RBC membrane due to the structural remodeling of the iRBC membrane microstructure.
published_date 2017-09-01T03:56:23Z
_version_ 1763752839713128448
score 11.012924

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