No Cover Image

Journal article 1160 views

A multiscale framework for large deformation modeling of RBC membranes

Adesola Ademiloye Orcid Logo, L.W. Zhang, K.M. Liew

Computer Methods in Applied Mechanics and Engineering, Volume: 329, Pages: 144 - 167

Swansea University Author: Adesola Ademiloye Orcid Logo

Full text not available from this repository: check for access using links below.

Check full text

DOI (Published version): 10.1016/j.cma.2017.10.004

Abstract

In the present contribution, a multiscale framework for nonlinear analysis of finite deformation of red blood cell (RBC) membrane is developed. The first-order Cauchy–Born rule is adopted to establish an atomistic enriched hyperelastic constitutive model and to develop macroscale stress–strain relat...

Full description

Published in: Computer Methods in Applied Mechanics and Engineering
ISSN: 0045-7825
Published: Elsevier BV 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa44904
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2018-10-16T13:47:48Z
last_indexed 2020-07-01T19:00:09Z
id cronfa44904
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2020-07-01T16:32:34.3096653</datestamp><bib-version>v2</bib-version><id>44904</id><entry>2018-10-16</entry><title>A multiscale framework for large deformation modeling of RBC membranes</title><swanseaauthors><author><sid>e37960ed89a7e3eaeba2201762626594</sid><ORCID>0000-0002-9741-6488</ORCID><firstname>Adesola</firstname><surname>Ademiloye</surname><name>Adesola Ademiloye</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-10-16</date><deptcode>MEDE</deptcode><abstract>In the present contribution, a multiscale framework for nonlinear analysis of finite deformation of red blood cell (RBC) membrane is developed. The first-order Cauchy&#x2013;Born rule is adopted to establish an atomistic enriched hyperelastic constitutive model and to develop macroscale stress&#x2013;strain relation of the RBC membrane. In order to circumvent the inherent limitations of utilizing mesh-based methods for large deformation analysis, we systematically coupled the 3D multiscale scheme with the element-free IMLS-Ritz method for numerical modeling of RBC deformability by simulating the optical tweezers experiment. This development was partly motivated by the need for a more precise scheme for modeling membrane structures. The effectiveness of the proposed approach is affirmed by the better prediction of RBC membrane deformability in comparison with experimental and numerical results found in literature and a significant reduction in computational cost. Our approach enables precise characterization of the effect of varying microstructure parameters, physiological, and osmolality conditions on the deformability of RBC membrane.</abstract><type>Journal Article</type><journal>Computer Methods in Applied Mechanics and Engineering</journal><volume>329</volume><paginationStart>144</paginationStart><paginationEnd>167</paginationEnd><publisher>Elsevier BV</publisher><issnPrint>0045-7825</issnPrint><keywords>Multiscale modeling, Cauchy&#x2013;Born rule, Element-free method, IMLS-Ritz method, Nonlinear large deformation analysis, RBC membrane</keywords><publishedDay>1</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-02-01</publishedDate><doi>10.1016/j.cma.2017.10.004</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-07-01T16:32:34.3096653</lastEdited><Created>2018-10-16T12:47:41.2917887</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Adesola</firstname><surname>Ademiloye</surname><orcid>0000-0002-9741-6488</orcid><order>1</order></author><author><firstname>L.W.</firstname><surname>Zhang</surname><order>2</order></author><author><firstname>K.M.</firstname><surname>Liew</surname><order>3</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2020-07-01T16:32:34.3096653 v2 44904 2018-10-16 A multiscale framework for large deformation modeling of RBC membranes e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE In the present contribution, a multiscale framework for nonlinear analysis of finite deformation of red blood cell (RBC) membrane is developed. The first-order Cauchy–Born rule is adopted to establish an atomistic enriched hyperelastic constitutive model and to develop macroscale stress–strain relation of the RBC membrane. In order to circumvent the inherent limitations of utilizing mesh-based methods for large deformation analysis, we systematically coupled the 3D multiscale scheme with the element-free IMLS-Ritz method for numerical modeling of RBC deformability by simulating the optical tweezers experiment. This development was partly motivated by the need for a more precise scheme for modeling membrane structures. The effectiveness of the proposed approach is affirmed by the better prediction of RBC membrane deformability in comparison with experimental and numerical results found in literature and a significant reduction in computational cost. Our approach enables precise characterization of the effect of varying microstructure parameters, physiological, and osmolality conditions on the deformability of RBC membrane. Journal Article Computer Methods in Applied Mechanics and Engineering 329 144 167 Elsevier BV 0045-7825 Multiscale modeling, Cauchy–Born rule, Element-free method, IMLS-Ritz method, Nonlinear large deformation analysis, RBC membrane 1 2 2018 2018-02-01 10.1016/j.cma.2017.10.004 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-07-01T16:32:34.3096653 2018-10-16T12:47:41.2917887 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Adesola Ademiloye 0000-0002-9741-6488 1 L.W. Zhang 2 K.M. Liew 3
title A multiscale framework for large deformation modeling of RBC membranes
spellingShingle A multiscale framework for large deformation modeling of RBC membranes
Adesola Ademiloye
title_short A multiscale framework for large deformation modeling of RBC membranes
title_full A multiscale framework for large deformation modeling of RBC membranes
title_fullStr A multiscale framework for large deformation modeling of RBC membranes
title_full_unstemmed A multiscale framework for large deformation modeling of RBC membranes
title_sort A multiscale framework for large deformation modeling of RBC membranes
author_id_str_mv e37960ed89a7e3eaeba2201762626594
author_id_fullname_str_mv e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
author Adesola Ademiloye
author2 Adesola Ademiloye
L.W. Zhang
K.M. Liew
format Journal article
container_title Computer Methods in Applied Mechanics and Engineering
container_volume 329
container_start_page 144
publishDate 2018
institution Swansea University
issn 0045-7825
doi_str_mv 10.1016/j.cma.2017.10.004
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description In the present contribution, a multiscale framework for nonlinear analysis of finite deformation of red blood cell (RBC) membrane is developed. The first-order Cauchy–Born rule is adopted to establish an atomistic enriched hyperelastic constitutive model and to develop macroscale stress–strain relation of the RBC membrane. In order to circumvent the inherent limitations of utilizing mesh-based methods for large deformation analysis, we systematically coupled the 3D multiscale scheme with the element-free IMLS-Ritz method for numerical modeling of RBC deformability by simulating the optical tweezers experiment. This development was partly motivated by the need for a more precise scheme for modeling membrane structures. The effectiveness of the proposed approach is affirmed by the better prediction of RBC membrane deformability in comparison with experimental and numerical results found in literature and a significant reduction in computational cost. Our approach enables precise characterization of the effect of varying microstructure parameters, physiological, and osmolality conditions on the deformability of RBC membrane.
published_date 2018-02-01T03:56:23Z
_version_ 1763752839469858816
score 11.017731

Similar Items