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A fully coupled fluid-structure interaction model of the secondary lymphatic valve

John T. Wilson, Lowell T. Edgar, Saurabh Prabhakar, Marc Horner, Raoul van Loon Orcid Logo, James E. Moore

Computer Methods in Biomechanics and Biomedical Engineering, Pages: 1 - 11

Swansea University Author: Raoul van Loon Orcid Logo

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DOI (Published version): 10.1080/10255842.2018.1521964

Abstract

The secondary lymphatic valve is a bi-leaflet structure frequent throughout collecting vessels that serves to prevent retrograde flow of lymph. Despite its vital function in lymph flow and apparent importance in disease development, the lymphatic valve and its associated fluid dynamics have been lar...

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Published in: Computer Methods in Biomechanics and Biomedical Engineering
ISSN: 1025-5842 1476-8259
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa43794
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first_indexed 2018-09-12T18:59:52Z
last_indexed 2018-11-26T14:18:19Z
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spelling 2018-11-26T11:35:10.7958594 v2 43794 2018-09-12 A fully coupled fluid-structure interaction model of the secondary lymphatic valve 880b30f90841a022f1e5bac32fb12193 0000-0003-3581-5827 Raoul van Loon Raoul van Loon true false 2018-09-12 MEDE The secondary lymphatic valve is a bi-leaflet structure frequent throughout collecting vessels that serves to prevent retrograde flow of lymph. Despite its vital function in lymph flow and apparent importance in disease development, the lymphatic valve and its associated fluid dynamics have been largely understudied. The goal of this work was to construct a physiologically relevant computational model of an idealized rat mesenteric lymphatic valve using fully coupled fluid-structure interactions to investigate the relationship between three-dimensional flow patterns and stress/deformation within the valve leaflets. The minimum valve resistance to flow, which has been shown to be an important parameter in effective lymphatic pumping, was computed as 268 g/mm4−s. Hysteretic behavior of the lymphatic valve was confirmed by comparing resistance values for a given transvalvular pressure drop during opening and closing. Furthermore, eddy structures were present within the sinus adjacent to the valve leaflets in what appear to be areas of vortical flow; the eddy structures were characterized by non-zero velocity values (up to ∼4 mm/s) in response to an applied unsteady transvalvular pressure. These modeling capabilities present a useful platform for investigating the complex interplay between soft tissue motion and fluid dynamics of lymphatic valves and contribute to the breadth of knowledge regarding the importance of biomechanics in lymphatic system function. Journal Article Computer Methods in Biomechanics and Biomedical Engineering 1 11 1025-5842 1476-8259 Fluid-structure interactions, fully coupled FSI, lymphatic system, lymphatic valve, lymphatic flow, flow resistance 31 12 2018 2018-12-31 10.1080/10255842.2018.1521964 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2018-11-26T11:35:10.7958594 2018-09-12T13:15:15.2220918 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering John T. Wilson 1 Lowell T. Edgar 2 Saurabh Prabhakar 3 Marc Horner 4 Raoul van Loon 0000-0003-3581-5827 5 James E. Moore 6 0043794-15102018153534.pdf wilson2018(2)v2.pdf 2018-10-15T15:35:34.7300000 Output 1112909 application/pdf Accepted Manuscript true 2019-11-06T00:00:00.0000000 true eng
title A fully coupled fluid-structure interaction model of the secondary lymphatic valve
spellingShingle A fully coupled fluid-structure interaction model of the secondary lymphatic valve
Raoul van Loon
title_short A fully coupled fluid-structure interaction model of the secondary lymphatic valve
title_full A fully coupled fluid-structure interaction model of the secondary lymphatic valve
title_fullStr A fully coupled fluid-structure interaction model of the secondary lymphatic valve
title_full_unstemmed A fully coupled fluid-structure interaction model of the secondary lymphatic valve
title_sort A fully coupled fluid-structure interaction model of the secondary lymphatic valve
author_id_str_mv 880b30f90841a022f1e5bac32fb12193
author_id_fullname_str_mv 880b30f90841a022f1e5bac32fb12193_***_Raoul van Loon
author Raoul van Loon
author2 John T. Wilson
Lowell T. Edgar
Saurabh Prabhakar
Marc Horner
Raoul van Loon
James E. Moore
format Journal article
container_title Computer Methods in Biomechanics and Biomedical Engineering
container_start_page 1
publishDate 2018
institution Swansea University
issn 1025-5842
1476-8259
doi_str_mv 10.1080/10255842.2018.1521964
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 1
active_str 0
description The secondary lymphatic valve is a bi-leaflet structure frequent throughout collecting vessels that serves to prevent retrograde flow of lymph. Despite its vital function in lymph flow and apparent importance in disease development, the lymphatic valve and its associated fluid dynamics have been largely understudied. The goal of this work was to construct a physiologically relevant computational model of an idealized rat mesenteric lymphatic valve using fully coupled fluid-structure interactions to investigate the relationship between three-dimensional flow patterns and stress/deformation within the valve leaflets. The minimum valve resistance to flow, which has been shown to be an important parameter in effective lymphatic pumping, was computed as 268 g/mm4−s. Hysteretic behavior of the lymphatic valve was confirmed by comparing resistance values for a given transvalvular pressure drop during opening and closing. Furthermore, eddy structures were present within the sinus adjacent to the valve leaflets in what appear to be areas of vortical flow; the eddy structures were characterized by non-zero velocity values (up to ∼4 mm/s) in response to an applied unsteady transvalvular pressure. These modeling capabilities present a useful platform for investigating the complex interplay between soft tissue motion and fluid dynamics of lymphatic valves and contribute to the breadth of knowledge regarding the importance of biomechanics in lymphatic system function.
published_date 2018-12-31T03:55:08Z
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score 11.037603

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