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Biomechanical properties and microstructure of neonatal porcine ventricles

Faizan Ahmad, Raj. Prabhu, Jun Liao, Shwe Soe, Michael D. Jones, Jonathan Miller, Parker Berthelson, Daniel Enge, Katherine M. Copeland, Samar Shaabeth, Richard Johnston Orcid Logo, Ian Maconochie, Peter S. Theobald

Journal of the Mechanical Behavior of Biomedical Materials, Volume: 88, Pages: 18 - 28

Swansea University Author: Richard Johnston Orcid Logo

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DOI (Published version): 10.1016/j.jmbbm.2018.07.038

Abstract

Neonatal heart disorders represent a major clinical challenge, with congenital heart disease alone affecting 36,000 new-borns annually within the European Union. Surgical intervention to restore normal function includes the implantation of synthetic and biological materials; however, a lack of exper...

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Published in: Journal of the Mechanical Behavior of Biomedical Materials
ISSN: 1751-6161
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa43488
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first_indexed 2018-08-15T18:55:52Z
last_indexed 2018-10-15T19:17:28Z
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Surgical intervention to restore normal function includes the implantation of synthetic and biological materials; however, a lack of experimental data describing the mechanical behaviour of neonatal cardiac tissue is likely to contribute to the relatively poor short- and long-term outcome of these implants. This study focused on characterising the mechanical behaviour of neonatal cardiac tissue using a porcine model, to enhance the understanding of how this differs to the equivalent mature tissue. The biomechanical properties of neonatal porcine cardiac tissue were characterised by uniaxial tensile, biaxial tensile, and simple shear loading modes, using samples collected from the anterior and posterior walls of the right and left ventricles. Histological images were prepared using Masson&#x2019;s trichrome staining, to enable assessment of the microstructure and correlation with tissue behaviour. The mechanical tests demonstrated that the neonatal cardiac tissue is non&#x2013;linear, anisotropic, viscoelastic and heterogeneous. Our data provide a baseline describing the biomechanical behaviour of immature porcine cardiac tissue. Comparison with published data also indicated that the neonatal porcine cardiac tissue exhibits one-half the stiffness of mature porcine tissue in uniaxial extension testing, one-third in biaxial extension testing, and one-fourth stiffness in simple shear testing; hence, it provides an indication as to the relative change in characteristics associated with tissue maturation. These data may prove valuable to researchers investigating neonatal cardiac mechanics.</abstract><type>Journal Article</type><journal>Journal of the Mechanical Behavior of Biomedical Materials</journal><volume>88</volume><paginationStart>18</paginationStart><paginationEnd>28</paginationEnd><publisher/><issnPrint>1751-6161</issnPrint><keywords>Neonate, Cardiac mechanics, Congenital heart disease, Passive mechanical behaviour, Age-dependent variations</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-12-31</publishedDate><doi>10.1016/j.jmbbm.2018.07.038</doi><url/><notes/><college>COLLEGE NANME</college><department>Materials Science and Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MTLS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2018-10-15T15:10:03.5776841</lastEdited><Created>2018-08-15T14:58:57.3253390</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Materials Science and Engineering</level></path><authors><author><firstname>Faizan</firstname><surname>Ahmad</surname><order>1</order></author><author><firstname>Ra&#xFEFF;j.</firstname><surname>Prabhu</surname><order>2</order></author><author><firstname>Jun</firstname><surname>Liao</surname><order>3</order></author><author><firstname>Shwe</firstname><surname>Soe</surname><order>4</order></author><author><firstname>Michael D.</firstname><surname>Jones</surname><order>5</order></author><author><firstname>Jonathan</firstname><surname>Miller</surname><order>6</order></author><author><firstname>Parker</firstname><surname>Berthelson</surname><order>7</order></author><author><firstname>Daniel</firstname><surname>Enge</surname><order>8</order></author><author><firstname>Katherine M.</firstname><surname>Copeland</surname><order>9</order></author><author><firstname>Samar</firstname><surname>Shaabeth</surname><order>10</order></author><author><firstname>Richard</firstname><surname>Johnston</surname><orcid>0000-0003-1977-6418</orcid><order>11</order></author><author><firstname>Ian</firstname><surname>Maconochie</surname><order>12</order></author><author><firstname>Peter S.</firstname><surname>Theobald</surname><order>13</order></author></authors><documents><document><filename>0043488-31082018111254.pdf</filename><originalFilename>ahmad2018(2).pdf</originalFilename><uploaded>2018-08-31T11:12:54.0630000</uploaded><type>Output</type><contentLength>2913707</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-07-29T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2018-10-15T15:10:03.5776841 v2 43488 2018-08-15 Biomechanical properties and microstructure of neonatal porcine ventricles 23282e7acce87dd926b8a62ae410a393 0000-0003-1977-6418 Richard Johnston Richard Johnston true false 2018-08-15 MTLS Neonatal heart disorders represent a major clinical challenge, with congenital heart disease alone affecting 36,000 new-borns annually within the European Union. Surgical intervention to restore normal function includes the implantation of synthetic and biological materials; however, a lack of experimental data describing the mechanical behaviour of neonatal cardiac tissue is likely to contribute to the relatively poor short- and long-term outcome of these implants. This study focused on characterising the mechanical behaviour of neonatal cardiac tissue using a porcine model, to enhance the understanding of how this differs to the equivalent mature tissue. The biomechanical properties of neonatal porcine cardiac tissue were characterised by uniaxial tensile, biaxial tensile, and simple shear loading modes, using samples collected from the anterior and posterior walls of the right and left ventricles. Histological images were prepared using Masson’s trichrome staining, to enable assessment of the microstructure and correlation with tissue behaviour. The mechanical tests demonstrated that the neonatal cardiac tissue is non–linear, anisotropic, viscoelastic and heterogeneous. Our data provide a baseline describing the biomechanical behaviour of immature porcine cardiac tissue. Comparison with published data also indicated that the neonatal porcine cardiac tissue exhibits one-half the stiffness of mature porcine tissue in uniaxial extension testing, one-third in biaxial extension testing, and one-fourth stiffness in simple shear testing; hence, it provides an indication as to the relative change in characteristics associated with tissue maturation. These data may prove valuable to researchers investigating neonatal cardiac mechanics. Journal Article Journal of the Mechanical Behavior of Biomedical Materials 88 18 28 1751-6161 Neonate, Cardiac mechanics, Congenital heart disease, Passive mechanical behaviour, Age-dependent variations 31 12 2018 2018-12-31 10.1016/j.jmbbm.2018.07.038 COLLEGE NANME Materials Science and Engineering COLLEGE CODE MTLS Swansea University 2018-10-15T15:10:03.5776841 2018-08-15T14:58:57.3253390 Faculty of Science and Engineering School of Engineering and Applied Sciences - Materials Science and Engineering Faizan Ahmad 1 Raj. Prabhu 2 Jun Liao 3 Shwe Soe 4 Michael D. Jones 5 Jonathan Miller 6 Parker Berthelson 7 Daniel Enge 8 Katherine M. Copeland 9 Samar Shaabeth 10 Richard Johnston 0000-0003-1977-6418 11 Ian Maconochie 12 Peter S. Theobald 13 0043488-31082018111254.pdf ahmad2018(2).pdf 2018-08-31T11:12:54.0630000 Output 2913707 application/pdf Accepted Manuscript true 2019-07-29T00:00:00.0000000 true eng
title Biomechanical properties and microstructure of neonatal porcine ventricles
spellingShingle Biomechanical properties and microstructure of neonatal porcine ventricles
Richard Johnston
title_short Biomechanical properties and microstructure of neonatal porcine ventricles
title_full Biomechanical properties and microstructure of neonatal porcine ventricles
title_fullStr Biomechanical properties and microstructure of neonatal porcine ventricles
title_full_unstemmed Biomechanical properties and microstructure of neonatal porcine ventricles
title_sort Biomechanical properties and microstructure of neonatal porcine ventricles
author_id_str_mv 23282e7acce87dd926b8a62ae410a393
author_id_fullname_str_mv 23282e7acce87dd926b8a62ae410a393_***_Richard Johnston
author Richard Johnston
author2 Faizan Ahmad
Raj. Prabhu
Jun Liao
Shwe Soe
Michael D. Jones
Jonathan Miller
Parker Berthelson
Daniel Enge
Katherine M. Copeland
Samar Shaabeth
Richard Johnston
Ian Maconochie
Peter S. Theobald
format Journal article
container_title Journal of the Mechanical Behavior of Biomedical Materials
container_volume 88
container_start_page 18
publishDate 2018
institution Swansea University
issn 1751-6161
doi_str_mv 10.1016/j.jmbbm.2018.07.038
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Materials Science and Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Materials Science and Engineering
document_store_str 1
active_str 0
description Neonatal heart disorders represent a major clinical challenge, with congenital heart disease alone affecting 36,000 new-borns annually within the European Union. Surgical intervention to restore normal function includes the implantation of synthetic and biological materials; however, a lack of experimental data describing the mechanical behaviour of neonatal cardiac tissue is likely to contribute to the relatively poor short- and long-term outcome of these implants. This study focused on characterising the mechanical behaviour of neonatal cardiac tissue using a porcine model, to enhance the understanding of how this differs to the equivalent mature tissue. The biomechanical properties of neonatal porcine cardiac tissue were characterised by uniaxial tensile, biaxial tensile, and simple shear loading modes, using samples collected from the anterior and posterior walls of the right and left ventricles. Histological images were prepared using Masson’s trichrome staining, to enable assessment of the microstructure and correlation with tissue behaviour. The mechanical tests demonstrated that the neonatal cardiac tissue is non–linear, anisotropic, viscoelastic and heterogeneous. Our data provide a baseline describing the biomechanical behaviour of immature porcine cardiac tissue. Comparison with published data also indicated that the neonatal porcine cardiac tissue exhibits one-half the stiffness of mature porcine tissue in uniaxial extension testing, one-third in biaxial extension testing, and one-fourth stiffness in simple shear testing; hence, it provides an indication as to the relative change in characteristics associated with tissue maturation. These data may prove valuable to researchers investigating neonatal cardiac mechanics.
published_date 2018-12-31T03:54:41Z
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score 11.014067

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