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The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals

Matthew Lawrence Orcid Logo, Gareth Davies, Michael Nyberg, Janet Whitley, Vanessa Evans, Rhodri Williams Orcid Logo, Ylva Hellsten, Phillip A. Evans, Adrian Evans

Thrombosis Research, Volume: 170, Pages: 32 - 37

Swansea University Authors: Matthew Lawrence Orcid Logo, Rhodri Williams Orcid Logo, Adrian Evans

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DOI (Published version): 10.1016/j.thromres.2018.07.025

Abstract

BackgroundThe long term benefits of exercise on the cardiovascular status of a patient have been proven, however, their benefit/risk relationship with exercise intensity is unclear. Furthermore, many thromboembolic diseases such as myocardial infarction and ischaemic stroke are associated with profo...

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Published in: Thrombosis Research
ISSN: 0049-3848
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa43363
first_indexed 2018-08-14T18:56:36Z
last_indexed 2018-11-26T14:17:33Z
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Furthermore, many thromboembolic diseases such as myocardial infarction and ischaemic stroke are associated with profound catecholamine release. In this study we explore the relationship between catecholamine release and hemodynamic changes and their effect on coagulation.Materials and methodsTwelve healthy recreationally active males were recruited. Local anesthesia was given and catheters were placed under aseptic conditions, in the femoral artery and vein of the experimental leg. The first experiment involved tyramine infusion into the femoral artery at a dose of 1.0&#x202F;&#x3BC;mol&#xB7;min&#x2212;1&#xB7;L&#x202F;leg&#x202F;volume&#x2212;1. The second experiment involved single leg knee-extensor exercise performed at 30&#x202F;W for 15&#x202F;min. Venous blood was collected at each time point to assess clot microstructure using the df biomarker.Results and conclusionsTyramine infusion causes a local noradrenaline release in the leg. The increase in noradrenaline was associated with a significant increase in clot microstructure formation (df increased from 1.692&#x202F;&#xB1;&#x202F;0.029 to 1.722&#x202F;&#xB1;&#x202F;0.047, p&#x202F;=&#x202F;0.016). Additionally moderate intensity single leg knee extensor exercise, which minimally alters sympathetic activity, also induced an increases in df (from 1.688&#x202F;&#xB1;&#x202F;0.025 to 1.723&#x202F;&#xB1;&#x202F;0.023, p&#x202F;=&#x202F;0.001). This suggests that exercise can alter clot microstructure formation both via an increase in catecholeamine levels and by factors related to muscle activity per se, such as increased blood flow and consequent shear. These findings have implications for recommendations of exercise in patients at risk of cardiovascular events.</abstract><type>Journal Article</type><journal>Thrombosis Research</journal><volume>170</volume><paginationStart>32</paginationStart><paginationEnd>37</paginationEnd><publisher/><issnPrint>0049-3848</issnPrint><keywords>Catecholamine, Clot microstructure, Coagulation, Exercise</keywords><publishedDay>31</publishedDay><publishedMonth>10</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-10-31</publishedDate><doi>10.1016/j.thromres.2018.07.025</doi><url/><notes/><college>COLLEGE NANME</college><department>Medical School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDS</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2018-11-26T11:34:05.5672894</lastEdited><Created>2018-08-14T14:19:09.3864547</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Chemical Engineering</level></path><authors><author><firstname>Matthew</firstname><surname>Lawrence</surname><orcid>0000-0001-7344-2836</orcid><order>1</order></author><author><firstname>Gareth</firstname><surname>Davies</surname><order>2</order></author><author><firstname>Michael</firstname><surname>Nyberg</surname><order>3</order></author><author><firstname>Janet</firstname><surname>Whitley</surname><order>4</order></author><author><firstname>Vanessa</firstname><surname>Evans</surname><order>5</order></author><author><firstname>Rhodri</firstname><surname>Williams</surname><orcid>0000-0002-6912-5288</orcid><order>6</order></author><author><firstname>Ylva</firstname><surname>Hellsten</surname><order>7</order></author><author><firstname>Phillip A.</firstname><surname>Evans</surname><order>8</order></author><author><firstname>Adrian</firstname><surname>Evans</surname><order>9</order></author></authors><documents><document><filename>0043363-11102018144911.pdf</filename><originalFilename>lawrence2018.pdf</originalFilename><uploaded>2018-10-11T14:49:11.8630000</uploaded><type>Output</type><contentLength>597738</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-10-27T00:00:00.0000000</embargoDate><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2018-11-26T11:34:05.5672894 v2 43363 2018-08-14 The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals 262d0cae7663ded863d6e2de15757f3c 0000-0001-7344-2836 Matthew Lawrence Matthew Lawrence true false 642bf793695f412ed932f1ea4d9bc3f1 0000-0002-6912-5288 Rhodri Williams Rhodri Williams true false 21761f6eb805546a561c9f036e85405b Adrian Evans Adrian Evans true false 2018-08-14 MEDS BackgroundThe long term benefits of exercise on the cardiovascular status of a patient have been proven, however, their benefit/risk relationship with exercise intensity is unclear. Furthermore, many thromboembolic diseases such as myocardial infarction and ischaemic stroke are associated with profound catecholamine release. In this study we explore the relationship between catecholamine release and hemodynamic changes and their effect on coagulation.Materials and methodsTwelve healthy recreationally active males were recruited. Local anesthesia was given and catheters were placed under aseptic conditions, in the femoral artery and vein of the experimental leg. The first experiment involved tyramine infusion into the femoral artery at a dose of 1.0 μmol·min−1·L leg volume−1. The second experiment involved single leg knee-extensor exercise performed at 30 W for 15 min. Venous blood was collected at each time point to assess clot microstructure using the df biomarker.Results and conclusionsTyramine infusion causes a local noradrenaline release in the leg. The increase in noradrenaline was associated with a significant increase in clot microstructure formation (df increased from 1.692 ± 0.029 to 1.722 ± 0.047, p = 0.016). Additionally moderate intensity single leg knee extensor exercise, which minimally alters sympathetic activity, also induced an increases in df (from 1.688 ± 0.025 to 1.723 ± 0.023, p = 0.001). This suggests that exercise can alter clot microstructure formation both via an increase in catecholeamine levels and by factors related to muscle activity per se, such as increased blood flow and consequent shear. These findings have implications for recommendations of exercise in patients at risk of cardiovascular events. Journal Article Thrombosis Research 170 32 37 0049-3848 Catecholamine, Clot microstructure, Coagulation, Exercise 31 10 2018 2018-10-31 10.1016/j.thromres.2018.07.025 COLLEGE NANME Medical School COLLEGE CODE MEDS Swansea University 2018-11-26T11:34:05.5672894 2018-08-14T14:19:09.3864547 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Matthew Lawrence 0000-0001-7344-2836 1 Gareth Davies 2 Michael Nyberg 3 Janet Whitley 4 Vanessa Evans 5 Rhodri Williams 0000-0002-6912-5288 6 Ylva Hellsten 7 Phillip A. Evans 8 Adrian Evans 9 0043363-11102018144911.pdf lawrence2018.pdf 2018-10-11T14:49:11.8630000 Output 597738 application/pdf Accepted Manuscript true 2019-10-27T00:00:00.0000000 true eng
title The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals
spellingShingle The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals
Matthew Lawrence
Rhodri Williams
Adrian Evans
title_short The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals
title_full The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals
title_fullStr The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals
title_full_unstemmed The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals
title_sort The effect of tyramine infusion and exercise on blood flow, coagulation and clot microstructure in healthy individuals
author_id_str_mv 262d0cae7663ded863d6e2de15757f3c
642bf793695f412ed932f1ea4d9bc3f1
21761f6eb805546a561c9f036e85405b
author_id_fullname_str_mv 262d0cae7663ded863d6e2de15757f3c_***_Matthew Lawrence
642bf793695f412ed932f1ea4d9bc3f1_***_Rhodri Williams
21761f6eb805546a561c9f036e85405b_***_Adrian Evans
author Matthew Lawrence
Rhodri Williams
Adrian Evans
author2 Matthew Lawrence
Gareth Davies
Michael Nyberg
Janet Whitley
Vanessa Evans
Rhodri Williams
Ylva Hellsten
Phillip A. Evans
Adrian Evans
format Journal article
container_title Thrombosis Research
container_volume 170
container_start_page 32
publishDate 2018
institution Swansea University
issn 0049-3848
doi_str_mv 10.1016/j.thromres.2018.07.025
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description BackgroundThe long term benefits of exercise on the cardiovascular status of a patient have been proven, however, their benefit/risk relationship with exercise intensity is unclear. Furthermore, many thromboembolic diseases such as myocardial infarction and ischaemic stroke are associated with profound catecholamine release. In this study we explore the relationship between catecholamine release and hemodynamic changes and their effect on coagulation.Materials and methodsTwelve healthy recreationally active males were recruited. Local anesthesia was given and catheters were placed under aseptic conditions, in the femoral artery and vein of the experimental leg. The first experiment involved tyramine infusion into the femoral artery at a dose of 1.0 μmol·min−1·L leg volume−1. The second experiment involved single leg knee-extensor exercise performed at 30 W for 15 min. Venous blood was collected at each time point to assess clot microstructure using the df biomarker.Results and conclusionsTyramine infusion causes a local noradrenaline release in the leg. The increase in noradrenaline was associated with a significant increase in clot microstructure formation (df increased from 1.692 ± 0.029 to 1.722 ± 0.047, p = 0.016). Additionally moderate intensity single leg knee extensor exercise, which minimally alters sympathetic activity, also induced an increases in df (from 1.688 ± 0.025 to 1.723 ± 0.023, p = 0.001). This suggests that exercise can alter clot microstructure formation both via an increase in catecholeamine levels and by factors related to muscle activity per se, such as increased blood flow and consequent shear. These findings have implications for recommendations of exercise in patients at risk of cardiovascular events.
published_date 2018-10-31T19:31:06Z
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