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Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods. / Karen Haggerty

Swansea University Author: Karen Haggerty

Abstract

Agrochemicals and pesticides are compounds of significant industrial and commercial importance. Over recent years, legislation has increased greatly and with this increased regulation, the necessity for trace impurity analysis of pesticides has grown. Modem chromatographic techniques with both UV an...

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Published: 2001
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
URI: https://cronfa.swan.ac.uk/Record/cronfa42684
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first_indexed 2018-08-02T18:55:18Z
last_indexed 2018-08-03T10:10:49Z
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spelling 2018-08-02T16:24:30.1021998 v2 42684 2018-08-02 Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods. eb998e960a825ca779d86e0e5e6bd5f2 NULL Karen Haggerty Karen Haggerty true true 2018-08-02 Agrochemicals and pesticides are compounds of significant industrial and commercial importance. Over recent years, legislation has increased greatly and with this increased regulation, the necessity for trace impurity analysis of pesticides has grown. Modem chromatographic techniques with both UV and mass spectrometric detection have been used in the study of pesticidal compounds to separate and characterise impurities present at low levels. The use of these techniques is evaluated and suggestions for future work are outlined. The use and analysis of the pesticidal study compounds are reviewed and the instrumental techniques of capillary electrophoresis (CE), mass spectrometry (MS) and high performance liquid chromatography (HPLC) are described. The quaternary ammonium herbicide Paraquat is amongst the most widely used herbicidal products worldwide. The technique of capillary zone electrophoresis (CZE) was evaluated as a means of separating paraquat from a mixture of related impurity compounds. The preconcentration technique of transient capillary isotachophoresis (tCITP) was examined as a means of improving detection limits. Both CZE and tCITP were used successfully in the analysis of technical paraquat. CE-MS was performed with varying levels of success. Flutriafol is a fungicidal compound widely used in the control of cereal diseases. HPLC methodology was developed for use in the separation of flutriafol from a mixture of related impurity compounds. The technique was successfully used in the analysis of a sample of production material with over 25 impurity peaks detected. HPLC-MS was performed and the use of SIM, SRM and CRM were investigated as a means of improving detection limits. HPLC-MS was used in the analysis of a production sample and over twenty peaks were detected in the total ion chromatogram (TIC). The mass spectral information obtained enabled the tentative identification of a number of impurities. E-Thesis Analytical chemistry. 31 12 2001 2001-12-31 COLLEGE NANME Chemistry COLLEGE CODE Swansea University Doctoral Ph.D 2018-08-02T16:24:30.1021998 2018-08-02T16:24:30.1021998 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Karen Haggerty NULL 1 0042684-02082018162513.pdf 10807453.pdf 2018-08-02T16:25:13.8470000 Output 11353546 application/pdf E-Thesis true 2018-08-02T16:25:13.8470000 false
title Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods.
spellingShingle Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods.
Karen Haggerty
title_short Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods.
title_full Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods.
title_fullStr Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods.
title_full_unstemmed Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods.
title_sort Analysis of agrochemical compounds and related impurities by chromatographic-mass spectrometric methods.
author_id_str_mv eb998e960a825ca779d86e0e5e6bd5f2
author_id_fullname_str_mv eb998e960a825ca779d86e0e5e6bd5f2_***_Karen Haggerty
author Karen Haggerty
author2 Karen Haggerty
format E-Thesis
publishDate 2001
institution Swansea University
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
document_store_str 1
active_str 0
description Agrochemicals and pesticides are compounds of significant industrial and commercial importance. Over recent years, legislation has increased greatly and with this increased regulation, the necessity for trace impurity analysis of pesticides has grown. Modem chromatographic techniques with both UV and mass spectrometric detection have been used in the study of pesticidal compounds to separate and characterise impurities present at low levels. The use of these techniques is evaluated and suggestions for future work are outlined. The use and analysis of the pesticidal study compounds are reviewed and the instrumental techniques of capillary electrophoresis (CE), mass spectrometry (MS) and high performance liquid chromatography (HPLC) are described. The quaternary ammonium herbicide Paraquat is amongst the most widely used herbicidal products worldwide. The technique of capillary zone electrophoresis (CZE) was evaluated as a means of separating paraquat from a mixture of related impurity compounds. The preconcentration technique of transient capillary isotachophoresis (tCITP) was examined as a means of improving detection limits. Both CZE and tCITP were used successfully in the analysis of technical paraquat. CE-MS was performed with varying levels of success. Flutriafol is a fungicidal compound widely used in the control of cereal diseases. HPLC methodology was developed for use in the separation of flutriafol from a mixture of related impurity compounds. The technique was successfully used in the analysis of a sample of production material with over 25 impurity peaks detected. HPLC-MS was performed and the use of SIM, SRM and CRM were investigated as a means of improving detection limits. HPLC-MS was used in the analysis of a production sample and over twenty peaks were detected in the total ion chromatogram (TIC). The mass spectral information obtained enabled the tentative identification of a number of impurities.
published_date 2001-12-31T03:53:27Z
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score 11.014291

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