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Investigation of archived accurate mass data in mass spectrometry. / Mesfer Mohamed Alamri

Swansea University Author: Mesfer Mohamed Alamri

Abstract

"This thesis presents an investigation of mass measurement accuracy in mass spectrometry using archived accurate mass measurement data obtained on different types of mass spectrometry instruments. A magnetic sector was used as the "gold standard" analyzer and other data obtained on el...

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Published: 2010
Institution: Swansea University
Degree level: Master of Philosophy
Degree name: M.Phil
URI: https://cronfa.swan.ac.uk/Record/cronfa42662
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first_indexed 2018-08-02T18:55:14Z
last_indexed 2019-10-21T16:48:14Z
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spelling 2018-08-31T09:31:51.4311384 v2 42662 2018-08-02 Investigation of archived accurate mass data in mass spectrometry. 5c309bdd0012a7547b4d23b27b5dcdd5 NULL Mesfer Mohamed Alamri Mesfer Mohamed Alamri true true 2018-08-02 "This thesis presents an investigation of mass measurement accuracy in mass spectrometry using archived accurate mass measurement data obtained on different types of mass spectrometry instruments. A magnetic sector was used as the "gold standard" analyzer and other data obtained on electrospray ionization fitted with Orbitrap and a MALDI time-of-flight instrument. More than 4500 accurate masses were obtained from the EPSRC National Mass Spectrometry Service Centre at Swansea University using the above instrument types. Different ionization methods are available; each has its own characteristics. In this study the ionization techniques used are chemical ionization (Cl), electron ionization (El), electrospray ionization (ESI), fast-atom bombardment (FAB) and matrix-assisted laser desorption/ionization (MALDI). These mass analyzers have different attributes, including the mass range, resolution and mass accuracy. Mass measurement accuracies (MMAs) are reported for a number of preferred techniques. Statistical calculations were made using various software pack-ages such as SPSS, AccMass (house software), Origin, Easyfit and Excel add-ins. The data contains view outliers which can significantly affect the accuracy and precision of the data as well as affecting the underlying statistical distribution predicted." E-Thesis Analytical chemistry. 31 12 2010 2010-12-31 COLLEGE NANME Chemistry COLLEGE CODE Swansea University Master of Philosophy M.Phil 2018-08-31T09:31:51.4311384 2018-08-02T16:24:30.0241979 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Mesfer Mohamed Alamri NULL 1 0042662-02082018162512.pdf 10805760.pdf 2018-08-02T16:25:12.0970000 Output 12805215 application/pdf E-Thesis true 2018-08-02T16:25:12.0970000 false
title Investigation of archived accurate mass data in mass spectrometry.
spellingShingle Investigation of archived accurate mass data in mass spectrometry.
Mesfer Mohamed Alamri
title_short Investigation of archived accurate mass data in mass spectrometry.
title_full Investigation of archived accurate mass data in mass spectrometry.
title_fullStr Investigation of archived accurate mass data in mass spectrometry.
title_full_unstemmed Investigation of archived accurate mass data in mass spectrometry.
title_sort Investigation of archived accurate mass data in mass spectrometry.
author_id_str_mv 5c309bdd0012a7547b4d23b27b5dcdd5
author_id_fullname_str_mv 5c309bdd0012a7547b4d23b27b5dcdd5_***_Mesfer Mohamed Alamri
author Mesfer Mohamed Alamri
author2 Mesfer Mohamed Alamri
format E-Thesis
publishDate 2010
institution Swansea University
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
document_store_str 1
active_str 0
description "This thesis presents an investigation of mass measurement accuracy in mass spectrometry using archived accurate mass measurement data obtained on different types of mass spectrometry instruments. A magnetic sector was used as the "gold standard" analyzer and other data obtained on electrospray ionization fitted with Orbitrap and a MALDI time-of-flight instrument. More than 4500 accurate masses were obtained from the EPSRC National Mass Spectrometry Service Centre at Swansea University using the above instrument types. Different ionization methods are available; each has its own characteristics. In this study the ionization techniques used are chemical ionization (Cl), electron ionization (El), electrospray ionization (ESI), fast-atom bombardment (FAB) and matrix-assisted laser desorption/ionization (MALDI). These mass analyzers have different attributes, including the mass range, resolution and mass accuracy. Mass measurement accuracies (MMAs) are reported for a number of preferred techniques. Statistical calculations were made using various software pack-ages such as SPSS, AccMass (house software), Origin, Easyfit and Excel add-ins. The data contains view outliers which can significantly affect the accuracy and precision of the data as well as affecting the underlying statistical distribution predicted."
published_date 2010-12-31T03:53:24Z
_version_ 1763752651843960832
score 11.013371

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