The photoreactive free radical in eumelanin

Mostert, Bernard; Rienecker, Shermiyah B.; Noble, Christopher; Hanson, Graeme R.; Meredith, Paul

doi:10.1126/sciadv.aaq1293

Journal article 1149 views 159 downloads

The photoreactive free radical in eumelanin

Bernard Mostert

, Shermiyah B. Rienecker, Christopher Noble, Graeme R. Hanson, Paul Meredith

Science Advances, Volume: 4, Issue: 3, Start page: eaaq1293

Swansea University Authors: Bernard Mostert , Paul Meredith

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DOI (Published version): 10.1126/sciadv.aaq1293

Abstract

Melanin is the primary photoprotecting pigment in humans as well as being implicated in the development of deadly melanoma. The material also conducts electricity and has thus become a bioelectronic model for proton-to-electron transduction. Central to these phenomena are its spin properties—notably...

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Published in:	Science Advances
ISSN:	2375-2548
Published:	American Association for the Advancement of Science (AAAS) 2018
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa39310
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first_indexed	2018-04-04T19:33:14Z
last_indexed	2021-01-23T04:01:36Z
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spelling	2021-01-22T12:12:51.7226893 v2 39310 2018-04-04 The photoreactive free radical in eumelanin a353503c976a7338c7708a32e82f451f 0000-0002-9590-2124 Bernard Mostert Bernard Mostert true false 31e8fe57fa180d418afd48c3af280c2e 0000-0002-9049-7414 Paul Meredith Paul Meredith true false 2018-04-04 SPH Melanin is the primary photoprotecting pigment in humans as well as being implicated in the development of deadly melanoma. The material also conducts electricity and has thus become a bioelectronic model for proton-to-electron transduction. Central to these phenomena are its spin properties—notably two linked species derived from carbon-centered and semiquinone radicals. Using a novel in situ photoinduced electron paramagnetic resonance technique with simultaneous electrical measurements, we have elucidated for the first time the distinct photoreactivity of the two different radical species. We find that the production of the semiquinone is light- and water-driven, explaining the electrical properties and revealing biologically relevant photoreactivity. Journal Article Science Advances 4 3 eaaq1293 American Association for the Advancement of Science (AAAS) 2375-2548 28 3 2018 2018-03-28 10.1126/sciadv.aaq1293 COLLEGE NANME Physics COLLEGE CODE SPH Swansea University 2021-01-22T12:12:51.7226893 2018-04-04T13:41:50.7724113 Faculty of Science and Engineering School of Biosciences, Geography and Physics - Physics Bernard Mostert 0000-0002-9590-2124 1 Shermiyah B. Rienecker 2 Christopher Noble 3 Graeme R. Hanson 4 Paul Meredith 0000-0002-9049-7414 5 0039310-16042018155515.pdf 39130.pdf 2018-04-16T15:55:15.6600000 Output 642694 application/pdf Version of Record true Released under a Creative Commons Attribution NonCommercial License 4.0 (CC-BY-NC). true eng http://creativecommons.org/licenses/by-nc/4.0/
title	The photoreactive free radical in eumelanin
spellingShingle	The photoreactive free radical in eumelanin Bernard Mostert Paul Meredith
title_short	The photoreactive free radical in eumelanin
title_full	The photoreactive free radical in eumelanin
title_fullStr	The photoreactive free radical in eumelanin
title_full_unstemmed	The photoreactive free radical in eumelanin
title_sort	The photoreactive free radical in eumelanin
author_id_str_mv	a353503c976a7338c7708a32e82f451f 31e8fe57fa180d418afd48c3af280c2e
author_id_fullname_str_mv	a353503c976a7338c7708a32e82f451f_*_Bernard Mostert 31e8fe57fa180d418afd48c3af280c2e_*_Paul Meredith
author	Bernard Mostert Paul Meredith
author2	Bernard Mostert Shermiyah B. Rienecker Christopher Noble Graeme R. Hanson Paul Meredith
format	Journal article
container_title	Science Advances
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container_issue	3
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publishDate	2018
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publisher	American Association for the Advancement of Science (AAAS)
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description	Melanin is the primary photoprotecting pigment in humans as well as being implicated in the development of deadly melanoma. The material also conducts electricity and has thus become a bioelectronic model for proton-to-electron transduction. Central to these phenomena are its spin properties—notably two linked species derived from carbon-centered and semiquinone radicals. Using a novel in situ photoinduced electron paramagnetic resonance technique with simultaneous electrical measurements, we have elucidated for the first time the distinct photoreactivity of the two different radical species. We find that the production of the semiquinone is light- and water-driven, explaining the electrical properties and revealing biologically relevant photoreactivity.
published_date	2018-03-28T03:49:54Z
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The photoreactive free radical in eumelanin

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