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Determination of prestress and elastic properties of virus capsids

Ankush Aggarwal Orcid Logo

Physical Review E, Volume: 97, Issue: 3

Swansea University Author: Ankush Aggarwal Orcid Logo

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DOI (Published version): 10.1103/PhysRevE.97.032414

Abstract

Virus capsids are protein shells which protect the virus genome, and determination of their mechanical properties has been a topic of interest because of their potential use in nanotechnology and therapeutics. It has been demonstrated that stresses exist in virus capsids, even in their equilibrium s...

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Published in: Physical Review E
ISSN: 2470-0045 2470-0053
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa38941
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first_indexed 2018-03-05T14:21:31Z
last_indexed 2018-05-01T19:37:27Z
id cronfa38941
recordtype SURis
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spelling 2018-05-01T16:39:24.0607849 v2 38941 2018-03-05 Determination of prestress and elastic properties of virus capsids 33985d0c2586398180c197dc170d7d19 0000-0002-1755-8807 Ankush Aggarwal Ankush Aggarwal true false 2018-03-05 EEN Virus capsids are protein shells which protect the virus genome, and determination of their mechanical properties has been a topic of interest because of their potential use in nanotechnology and therapeutics. It has been demonstrated that stresses exist in virus capsids, even in their equilibrium state, due to their construction. These stresses, termed ``pre-stresses'' in this study, closely affect the capsid's mechanical behavior. Three methods --- shape-based metric, atomic force microscope indentation, and molecular dynamics --- have been proposed to determine the capsid elastic properties without fully accounting for pre-stresses. In this paper, we theoretically analyze the three methods used for mechanical characterization of virus capsids and numerically investigate how pre-stresses affect the capsid's mechanical properties. We consolidate all the results and propose that by using these techniques collectively, it is possible to accurately determine both the mechanical properties and pre-stresses in capsids. Journal Article Physical Review E 97 3 2470-0045 2470-0053 31 12 2018 2018-12-31 10.1103/PhysRevE.97.032414 COLLEGE NANME Engineering COLLEGE CODE EEN Swansea University 2018-05-01T16:39:24.0607849 2018-03-05T09:34:31.7770468 Faculty of Science and Engineering School of Engineering and Applied Sciences - Uncategorised Ankush Aggarwal 0000-0002-1755-8807 1 0038941-05032018093607.pdf aggarwal2018.pdf 2018-03-05T09:36:07.0000000 Output 5650826 application/pdf Accepted Manuscript true 2018-03-05T00:00:00.0000000 true eng
title Determination of prestress and elastic properties of virus capsids
spellingShingle Determination of prestress and elastic properties of virus capsids
Ankush Aggarwal
title_short Determination of prestress and elastic properties of virus capsids
title_full Determination of prestress and elastic properties of virus capsids
title_fullStr Determination of prestress and elastic properties of virus capsids
title_full_unstemmed Determination of prestress and elastic properties of virus capsids
title_sort Determination of prestress and elastic properties of virus capsids
author_id_str_mv 33985d0c2586398180c197dc170d7d19
author_id_fullname_str_mv 33985d0c2586398180c197dc170d7d19_***_Ankush Aggarwal
author Ankush Aggarwal
author2 Ankush Aggarwal
format Journal article
container_title Physical Review E
container_volume 97
container_issue 3
publishDate 2018
institution Swansea University
issn 2470-0045
2470-0053
doi_str_mv 10.1103/PhysRevE.97.032414
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Uncategorised{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Uncategorised
document_store_str 1
active_str 0
description Virus capsids are protein shells which protect the virus genome, and determination of their mechanical properties has been a topic of interest because of their potential use in nanotechnology and therapeutics. It has been demonstrated that stresses exist in virus capsids, even in their equilibrium state, due to their construction. These stresses, termed ``pre-stresses'' in this study, closely affect the capsid's mechanical behavior. Three methods --- shape-based metric, atomic force microscope indentation, and molecular dynamics --- have been proposed to determine the capsid elastic properties without fully accounting for pre-stresses. In this paper, we theoretically analyze the three methods used for mechanical characterization of virus capsids and numerically investigate how pre-stresses affect the capsid's mechanical properties. We consolidate all the results and propose that by using these techniques collectively, it is possible to accurately determine both the mechanical properties and pre-stresses in capsids.
published_date 2018-12-31T03:49:25Z
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score 11.031177

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