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A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery

Othmar Moser, Julia Münzker, Stefan Korsatko, Christoph Pachler, Karlheinz Smolle, Wolfgang Toller, Thomas Augustin, Johannes Plank, Thomas R. Pieber, Julia K. Mader, Martin Ellmerer

Scientific Reports, Volume: 8, Issue: 1

Swansea University Author: Othmar Moser

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DOI (Published version): 10.1038/s41598-018-19768-2

Abstract

We evaluated a standard subcutaneous microdialysis technique for glucose monitoring in two critically ill patient populations and tested whether a prolonged run-in period improves the quality of the interstitial glucose signal. 20 surgical patients after major cardiac surgery (APACHE II score: 10.1 ...

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Published in: Scientific Reports
ISSN: 2045-2322
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa38366
first_indexed 2018-02-01T14:21:57Z
last_indexed 2018-03-13T20:21:45Z
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spelling 2018-03-13T16:27:13.8475014 v2 38366 2018-02-01 A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery 3b249efea402d5413effa1e67f31bdfa Othmar Moser Othmar Moser true false 2018-02-01 EAAS We evaluated a standard subcutaneous microdialysis technique for glucose monitoring in two critically ill patient populations and tested whether a prolonged run-in period improves the quality of the interstitial glucose signal. 20 surgical patients after major cardiac surgery (APACHE II score: 10.1 ± 3.2) and 10 medical patients with severe sepsis (APACHE II score: 31.1 ± 4.3) were included in this investigation. A microdialysis catheter was inserted in the subcutaneous adipose tissue of the abdominal region. Interstitial fluid and arterial blood were sampled in hourly intervals to analyse glucose concentrations. Subcutaneous adipose tissue glucose was prospectively calibrated to reference arterial blood either at hour 1 or at hour 6. Median absolute relative difference of glucose (MARD), calibrated at hour 6 (6.2 (2.6; 12.4) %) versus hour 1 (9.9 (4.2; 17.9) %) after catheter insertion indicated a significant improvement in signal quality in patients after major cardiac surgery (p < 0.001). Prolonged run-in period revealed no significant improvement in patients with severe sepsis, but the number of extreme deviations from the blood plasma values could be reduced. Improved concurrence of glucose readings via a 6-hour run-in period could only be achieved in patients after major cardiac surgery. Journal Article Scientific Reports 8 1 2045-2322 Diagnostic markers, Metabolic engineering 19 1 2018 2018-01-19 10.1038/s41598-018-19768-2 COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University 2018-03-13T16:27:13.8475014 2018-02-01T09:17:20.1111539 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Othmar Moser 1 Julia Münzker 2 Stefan Korsatko 3 Christoph Pachler 4 Karlheinz Smolle 5 Wolfgang Toller 6 Thomas Augustin 7 Johannes Plank 8 Thomas R. Pieber 9 Julia K. Mader 10 Martin Ellmerer 11 0038366-01022018092017.pdf moser2018(2).pdf 2018-02-01T09:20:17.1430000 Output 1842161 application/pdf Version of Record true 2018-02-01T00:00:00.0000000 true eng
title A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery
spellingShingle A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery
Othmar Moser
title_short A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery
title_full A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery
title_fullStr A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery
title_full_unstemmed A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery
title_sort A prolonged run-in period of standard subcutaneous microdialysis ameliorates quality of interstitial glucose signal in patients after major cardiac surgery
author_id_str_mv 3b249efea402d5413effa1e67f31bdfa
author_id_fullname_str_mv 3b249efea402d5413effa1e67f31bdfa_***_Othmar Moser
author Othmar Moser
author2 Othmar Moser
Julia Münzker
Stefan Korsatko
Christoph Pachler
Karlheinz Smolle
Wolfgang Toller
Thomas Augustin
Johannes Plank
Thomas R. Pieber
Julia K. Mader
Martin Ellmerer
format Journal article
container_title Scientific Reports
container_volume 8
container_issue 1
publishDate 2018
institution Swansea University
issn 2045-2322
doi_str_mv 10.1038/s41598-018-19768-2
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
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description We evaluated a standard subcutaneous microdialysis technique for glucose monitoring in two critically ill patient populations and tested whether a prolonged run-in period improves the quality of the interstitial glucose signal. 20 surgical patients after major cardiac surgery (APACHE II score: 10.1 ± 3.2) and 10 medical patients with severe sepsis (APACHE II score: 31.1 ± 4.3) were included in this investigation. A microdialysis catheter was inserted in the subcutaneous adipose tissue of the abdominal region. Interstitial fluid and arterial blood were sampled in hourly intervals to analyse glucose concentrations. Subcutaneous adipose tissue glucose was prospectively calibrated to reference arterial blood either at hour 1 or at hour 6. Median absolute relative difference of glucose (MARD), calibrated at hour 6 (6.2 (2.6; 12.4) %) versus hour 1 (9.9 (4.2; 17.9) %) after catheter insertion indicated a significant improvement in signal quality in patients after major cardiac surgery (p < 0.001). Prolonged run-in period revealed no significant improvement in patients with severe sepsis, but the number of extreme deviations from the blood plasma values could be reduced. Improved concurrence of glucose readings via a 6-hour run-in period could only be achieved in patients after major cardiac surgery.
published_date 2018-01-19T04:17:57Z
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