No Cover Image

Journal article 1320 views 135 downloads

A Lumped Parameter Model to Study Atrioventricular Valve Regurgitation in Stage 1 and Changes Across Stage 2 Surgery in Single Ventricle Patients

Sanjay Pant Orcid Logo, Chiara Corsini, Catriona Baker, Tain-Yen Hsia, Giancarlo Pennati, Irene E. Vignon-Clementel

IEEE Transactions on Biomedical Engineering, Volume: 65, Issue: 11, Pages: 2450 - 2458

Swansea University Author: Sanjay Pant Orcid Logo

Check full text

DOI (Published version): 10.1109/tbme.2018.2797999

Abstract

Goal: This manuscript evaluates atrioventricular valve regurgitation (AVVR) in babies born with an already very challenging heart condition, i.e. with single ventricle physiology. Although the second surgery that single ventricle patients undergo is thought to decrease AVVR, there is much controvers...

Full description

Published in: IEEE Transactions on Biomedical Engineering
ISSN: 0018-9294 1558-2531
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa38236
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Goal: This manuscript evaluates atrioventricular valve regurgitation (AVVR) in babies born with an already very challenging heart condition, i.e. with single ventricle physiology. Although the second surgery that single ventricle patients undergo is thought to decrease AVVR, there is much controversy in the clinical literature about AVVR treatment. Methods: The effect of atrioventricular valve regurgitation (AVVR) on Stage 1 haemodynamics and resulting acute changes from conversion to Stage 2 circulation in single ventricle patients are analysed through lumped parameter models. Several degrees of AVVR severity are analysed, for two types of valve regurgitation: incomplete leaflet closure and valve prolapse. Results: The models show that increasing AVVR in Stage 1 induces the following effects: i) higher stroke volume and associated decrease in ventricular end-systolic volume; ii) increase in atrial volumes with V-loop enlargement in pressure-volume curves; iii) pulmonary venous hypertension. The Stage 2 surgery results in volume unloading of the ventricle thereby driving a decrease in AVVR. However, this effect is offset by an increase in ventricular pressures resulting in a net increase in regurgitation fraction (RF) of approximately 0.1 (for example, in severe AVVR, the pre-operative RF increases from ~60% to ~70% post-operatively). Moreover, despite some improvements to sarcomere function early after Stage 2 surgery, it may deteriorate in cases of severe AVVR. Conclusion: In patients with moderate to severe AVVR, restoration of atrioventricular valve competence prior to, or at the time of, Stage 2 surgery would likely lead to improved haemodynamics and clinical outcome as the models suggest that uncorrected AVVR can worsen across Stage 2 surgery. This was found to be independent of the AVVR degree and mechanisms.
College: Faculty of Science and Engineering
Issue: 11
Start Page: 2450
End Page: 2458

Similar Items