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Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes

Othmar Moser, Max Eckstein, Olivia McCarthy, Rachel Deere, Steve Bain Orcid Logo, Hanne L. Haahr, Eric Zijlstra, Richard Bracken Orcid Logo

Diabetology & Metabolic Syndrome, Volume: 9, Issue: 1

Swansea University Authors: Othmar Moser, Max Eckstein, Olivia McCarthy, Rachel Deere, Steve Bain Orcid Logo, Richard Bracken Orcid Logo

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DOI (Published version): 10.1186/s13098-017-0294-1

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BackgroundTo explore the impact of glycaemic control (HbA1c) on functional capacity during cardio-pulmonary exercise testing in people with type 1 diabetes.MethodsSixty-four individuals with type 1 diabetes (age: 34 ± 8 years; 13 females, HbA1c: 7.8 ± 1% (62 ± 13 mmol/mol), duration of diabetes: 17...

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Published in: Diabetology & Metabolic Syndrome
ISSN: 1758-5996
Published: Springer Science and Business Media LLC 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa37329
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Stepwise linear regression was used to explore relationships between HbA1c and cardio-respiratory data with p &#x2264; 0.05. Furthermore, participants were divided into quartiles based on HbA1c levels and cardio-respiratory data were analysed by one-way ANOVA. Multiple regression analysis was performed to explore the relationships between changes in time to exhaustion and cardio-respiratory data. Data were adjusted for confounder.ResultsHbA1c was related to time to exhaustion and oxygen consumption at the power output elicited at the sub-maximal threshold of the heart rate turn point (r = 0.47, R2 = 0.22, p = 0.03). Significant differences were found at time to exhaustion between QI vs. QIV and at oxygen consumption at the power output elicited at the heart rate turn point between QI vs. QII and QI vs. QIV (p &lt; 0.05). Changes in oxygen uptake, power output and in oxygen consumption at the power output elicited at the heart rate turn point and at maximum power output explained 55% of the variance in time to exhaustion (r = 0.74, R2 = 0.55, p &lt; 0.01).ConclusionsPoor glycaemic control is related to less economical use of oxygen at sub-maximal work rates and an earlier time to exhaustion during cardio-pulmonary exercise testing. 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spelling 2022-12-02T19:07:47.1751582 v2 37329 2017-12-05 Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes 3b249efea402d5413effa1e67f31bdfa Othmar Moser Othmar Moser true false 88e3800018f862425765f3e36da8de30 Max Eckstein Max Eckstein true false 4fea3e19b39712dea1d051d317614572 Olivia McCarthy Olivia McCarthy true false 3fd2ee8d0217f8487c472f52ba7c6b0a Rachel Deere Rachel Deere true false 5399f4c6e6a70f3608a084ddb938511a 0000-0001-8519-4964 Steve Bain Steve Bain true false f5da81cd18adfdedb2ccb845bddc12f7 0000-0002-6986-6449 Richard Bracken Richard Bracken true false 2017-12-05 STSC BackgroundTo explore the impact of glycaemic control (HbA1c) on functional capacity during cardio-pulmonary exercise testing in people with type 1 diabetes.MethodsSixty-four individuals with type 1 diabetes (age: 34 ± 8 years; 13 females, HbA1c: 7.8 ± 1% (62 ± 13 mmol/mol), duration of diabetes: 17 ± 9 years) performed a cardio-pulmonary cycle ergometer exercise test until volitional exhaustion. Stepwise linear regression was used to explore relationships between HbA1c and cardio-respiratory data with p ≤ 0.05. Furthermore, participants were divided into quartiles based on HbA1c levels and cardio-respiratory data were analysed by one-way ANOVA. Multiple regression analysis was performed to explore the relationships between changes in time to exhaustion and cardio-respiratory data. Data were adjusted for confounder.ResultsHbA1c was related to time to exhaustion and oxygen consumption at the power output elicited at the sub-maximal threshold of the heart rate turn point (r = 0.47, R2 = 0.22, p = 0.03). Significant differences were found at time to exhaustion between QI vs. QIV and at oxygen consumption at the power output elicited at the heart rate turn point between QI vs. QII and QI vs. QIV (p < 0.05). Changes in oxygen uptake, power output and in oxygen consumption at the power output elicited at the heart rate turn point and at maximum power output explained 55% of the variance in time to exhaustion (r = 0.74, R2 = 0.55, p < 0.01).ConclusionsPoor glycaemic control is related to less economical use of oxygen at sub-maximal work rates and an earlier time to exhaustion during cardio-pulmonary exercise testing. However, exercise training could have the same potential to counteract the influence of poor glycaemic control on functional capacity. Journal Article Diabetology &amp; Metabolic Syndrome 9 1 Springer Science and Business Media LLC 1758-5996 Glycaemic control, Exercise performance, Oxygen economy, Type 1 diabetes, Heart rate turn point 21 11 2017 2017-11-21 10.1186/s13098-017-0294-1 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2022-12-02T19:07:47.1751582 2017-12-05T12:46:41.2598771 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Othmar Moser 1 Max Eckstein 2 Olivia McCarthy 3 Rachel Deere 4 Steve Bain 0000-0001-8519-4964 5 Hanne L. Haahr 6 Eric Zijlstra 7 Richard Bracken 0000-0002-6986-6449 8 0037329-05122017124918.pdf moser2017(3).pdf 2017-12-05T12:49:18.8330000 Output 835917 application/pdf Version of Record true 2017-12-05T00:00:00.0000000 false eng
title Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes
spellingShingle Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes
Othmar Moser
Max Eckstein
Olivia McCarthy
Rachel Deere
Steve Bain
Richard Bracken
title_short Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes
title_full Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes
title_fullStr Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes
title_full_unstemmed Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes
title_sort Poor glycaemic control is associated with reduced exercise performance and oxygen economy during cardio-pulmonary exercise testing in people with type 1 diabetes
author_id_str_mv 3b249efea402d5413effa1e67f31bdfa
88e3800018f862425765f3e36da8de30
4fea3e19b39712dea1d051d317614572
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5399f4c6e6a70f3608a084ddb938511a
f5da81cd18adfdedb2ccb845bddc12f7
author_id_fullname_str_mv 3b249efea402d5413effa1e67f31bdfa_***_Othmar Moser
88e3800018f862425765f3e36da8de30_***_Max Eckstein
4fea3e19b39712dea1d051d317614572_***_Olivia McCarthy
3fd2ee8d0217f8487c472f52ba7c6b0a_***_Rachel Deere
5399f4c6e6a70f3608a084ddb938511a_***_Steve Bain
f5da81cd18adfdedb2ccb845bddc12f7_***_Richard Bracken
author Othmar Moser
Max Eckstein
Olivia McCarthy
Rachel Deere
Steve Bain
Richard Bracken
author2 Othmar Moser
Max Eckstein
Olivia McCarthy
Rachel Deere
Steve Bain
Hanne L. Haahr
Eric Zijlstra
Richard Bracken
format Journal article
container_title Diabetology &amp; Metabolic Syndrome
container_volume 9
container_issue 1
publishDate 2017
institution Swansea University
issn 1758-5996
doi_str_mv 10.1186/s13098-017-0294-1
publisher Springer Science and Business Media LLC
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str 1
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description BackgroundTo explore the impact of glycaemic control (HbA1c) on functional capacity during cardio-pulmonary exercise testing in people with type 1 diabetes.MethodsSixty-four individuals with type 1 diabetes (age: 34 ± 8 years; 13 females, HbA1c: 7.8 ± 1% (62 ± 13 mmol/mol), duration of diabetes: 17 ± 9 years) performed a cardio-pulmonary cycle ergometer exercise test until volitional exhaustion. Stepwise linear regression was used to explore relationships between HbA1c and cardio-respiratory data with p ≤ 0.05. Furthermore, participants were divided into quartiles based on HbA1c levels and cardio-respiratory data were analysed by one-way ANOVA. Multiple regression analysis was performed to explore the relationships between changes in time to exhaustion and cardio-respiratory data. Data were adjusted for confounder.ResultsHbA1c was related to time to exhaustion and oxygen consumption at the power output elicited at the sub-maximal threshold of the heart rate turn point (r = 0.47, R2 = 0.22, p = 0.03). Significant differences were found at time to exhaustion between QI vs. QIV and at oxygen consumption at the power output elicited at the heart rate turn point between QI vs. QII and QI vs. QIV (p < 0.05). Changes in oxygen uptake, power output and in oxygen consumption at the power output elicited at the heart rate turn point and at maximum power output explained 55% of the variance in time to exhaustion (r = 0.74, R2 = 0.55, p < 0.01).ConclusionsPoor glycaemic control is related to less economical use of oxygen at sub-maximal work rates and an earlier time to exhaustion during cardio-pulmonary exercise testing. However, exercise training could have the same potential to counteract the influence of poor glycaemic control on functional capacity.
published_date 2017-11-21T03:47:00Z
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